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Chromatin organization and behavior in -transformed mouse fibroblasts
Chromatin organization and behavior in -transformed mouse fibroblasts
In higher eukaryotic cells, a string of nucleosomes, where long genomic DNA is wrapped around core histones, are rather ir...
Interspecific cytogenomic comparison reveals a potential chromosomal centromeric marker in frog species
Interspecific cytogenomic comparison reveals a potential chromosomal centromeric marker in frog species
Among the repetitive elements, satellite DNA (SatDNA) emerges as extensive arrays of highly similar tandemly repeated unit...
Novel centromeric repetitive DNA elements reveal karyotype dynamics in polyploid sainfoin ()
Novel centromeric repetitive DNA elements reveal karyotype dynamics in polyploid sainfoin ()
Polyploidy is a common feature in eukaryotes with one of paramount consequences leading to better environmental adaptation...
Genome location, evolution and centromeric contribution of satellite DNAs shared between the two closely related species ( group, cluster)
Genome location, evolution and centromeric contribution of satellite DNAs shared between the two closely related species ( group, cluster)
Satellite DNAs are highly repetitive, tandemly arranged sequences, typically making up large portions (> 20%)...
Towards identification of a holocentromere marker in the lepidopteran model
Towards identification of a holocentromere marker in the lepidopteran model
Some insects have holocentric chromosomes, with multiple kinetochores rather than a single centromere. They also lack the ...
Tetraploidy in normal tissues and diseases: mechanisms and consequences
Tetraploidy in normal tissues and diseases: mechanisms and consequences
Tetraploidisation plays a crucial role in evolution, development, stress adaptation, and disease, but its beneficial or pa...
Regulatory effects of lncRNA PVT1 on transcriptome in human breast cancer MDA-MB-231 cell line determined by in silico analyses
Regulatory effects of lncRNA PVT1 on transcriptome in human breast cancer MDA-MB-231 cell line determined by in silico analyses
Overexpression or knockdown of a specific gene is usually helpful in understanding its underlying molecular mechanism. PVT...
RAD18 promotes cell malignant behaviors of esophageal squamous cell carcinoma by modulating ATM/STAT3/PD-L1
RAD18 promotes cell malignant behaviors of esophageal squamous cell carcinoma by modulating ATM/STAT3/PD-L1
Esophageal cancer (EC) is still a difficult problem in medicine, depriving many patients of their lives every year. RAD18 ...
A tribute to 40 years of CENP-A & centromere pioneer Bill Earnshaw
A tribute to 40 years of CENP-A & centromere pioneer Bill Earnshaw
Bergmann JH, Rodríguez MG, Martins NMC, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LET, Earnshaw WC (2011) Epigene...
A tribute to ,
A tribute to ,
Chromosoma, now in its 86th year, remains as respected a journal as it ever was. Yet,...
CCAAT Promoter element regulates transgenerational expression of the MHC class I gene
CCAAT Promoter element regulates transgenerational expression of the MHC class I gene
Transgenerational gene expression depends on both underlying DNA sequences and epigenetic modifications. The latter, which...
Multifaceted role of CTCF in X-chromosome inactivation
Multifaceted role of CTCF in X-chromosome inactivation
Therian female mammals compensate for the dosage of X-linked gene expression by inactivating one of the X-chromosomes. X-i...
Genome location, evolution and centromeric contribution of satellite DNAs shared between the two closely related species Drosophila serido and D. antonietae (repleta group, buzzatii cluster)
Genome location, evolution and centromeric contribution of satellite DNAs shared between the two closely related species Drosophila serido and D. antonietae (repleta group, buzzatii cluster)
Satellite DNAs are highly repetitive, tandemly arranged sequences, typically making up large portions (> 20%)...
Novel centromeric repetitive DNA elements reveal karyotype dynamics in polyploid sainfoin (Onobrychis viciifolia)
Novel centromeric repetitive DNA elements reveal karyotype dynamics in polyploid sainfoin (Onobrychis viciifolia)
Polyploidy is a common feature in eukaryotes with one of paramount consequences leading to better environmental adaptation...
Maintenance of genome integrity under physical constraints
Maintenance of genome integrity under physical constraints
“Interdisciplinary science” and “breaking down silos” have been buzz phrases for many...
Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus
Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus
Genome sequencing has identified hundreds of histone post-translational modifications (PTMs) that define an open or compac...
Interspecific cytogenomic comparison reveals a potential chromosomal centromeric marker in Proceratophrys frog species
Interspecific cytogenomic comparison reveals a potential chromosomal centromeric marker in Proceratophrys frog species
Among the repetitive elements, satellite DNA (SatDNA) emerges as extensive arrays of highly similar tandemly repeated unit...
Meiosis through three centuries
Meiosis through three centuries
Meiosis is the specialized cellular program that underlies gamete formation for sexual reproduction. It is therefore not o...
Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I
Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I
In eukaryotes, meiosis is the genetic basis for sexual reproduction, which is important for chromosome stability and speci...
Chromatin organization and behavior in HRAS-transformed mouse fibroblasts
Chromatin organization and behavior in HRAS-transformed mouse fibroblasts
In higher eukaryotic cells, a string of nucleosomes, where long genomic DNA is wrapped around core histones, are rather ir...
Vertebrate centromere architecture: from chromatin threads to functional structures
Vertebrate centromere architecture: from chromatin threads to functional structures
Centromeres are chromatin structures specialized in sister chromatid cohesion, kinetochore assembly, and microtubule attac...
Dicentric chromosomes are resolved through breakage and repair at their centromeres
Dicentric chromosomes are resolved through breakage and repair at their centromeres
Chromosomes with two centromeres provide a unique opportunity to study chromosome breakage and DNA repair using completely...
DNA replication and replication stress response in the context of nuclear architecture
DNA replication and replication stress response in the context of nuclear architecture
The DNA replication process needs to be coordinated with other DNA metabolism transactions and must eventually extend to t...
Karyotypes of water frogs from the Pelophylax esculentus complex: results of cross-species chromosomal painting
Karyotypes of water frogs from the Pelophylax esculentus complex: results of cross-species chromosomal painting
Amphibian species have the largest genome size enriched with repetitive sequences and relatively similar karyotypes. Moreo...
CTCF is essential for proper mitotic spindle structure and anaphase segregation
CTCF is essential for proper mitotic spindle structure and anaphase segregation
Mitosis is an essential process in which the duplicated genome is segregated equally into two daughter cells. CTCF has bee...
H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos
H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos
Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococc...
Nucleolin is required for multiple centrosome-associated functions in early vertebrate mitosis
Nucleolin is required for multiple centrosome-associated functions in early vertebrate mitosis
Nucleolin is a multifunctional RNA-binding protein that resides predominantly not only in the nucleolus, but also in multi...
Genome maintenance meets mechanobiology
Genome maintenance meets mechanobiology
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallm...
Cross-species chromosome painting and repetitive DNA mapping illuminate the karyotype evolution in true crocodiles (Crocodylidae)
Cross-species chromosome painting and repetitive DNA mapping illuminate the karyotype evolution in true crocodiles (Crocodylidae)
Crocodilians have maintained very similar karyotype structures and diploid chromosome numbers for around 100 million years...
New voices in epigenetics
New voices in epigenetics
A recent article in The Smithsonian Magazine (Doudna 2023) by Nobel Laureate Jennifer Doudna described seminal contributio...
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