Anatskaya OV, Vinogradov AE (2022a) Polyploidy and myc proto-oncogenes promote stress adaptation via epigenetic plasticity and gene regulatory network rewiring. Int J Mol Sci 23:9691

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anatskaya OV, Vinogradov AE (2022b) Polyploidy as a fundamental phenomenon in evolution, development, adaptation and diseases. Int J Mol Sci 23:3542

Article  PubMed  PubMed Central  Google Scholar 

Andreassen PR, Lohez OD, Lacroix FB, Margolis RL (2001) Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell 12:1315–1328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anjur-Dietrich MI, Kelleher CP, Needleman DJ (2021) Mechanical mechanisms of chromosome segregation. Cells 10:465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antonelli Y, Krüger R, Buehler A, Monavari M, Fuentes-Chandía M, Colombo F, Palmisano R, Boßerhoff AK, Kappelmann-Fenzl M, Schödel J, Boccaccini AR (2024) When mechanical stress matters: generation of polyploid giant cancer cells in tumor-like microcapsules. Adv Funct Mater 34(35):2311139

Article  CAS  Google Scholar 

Aranda F, Chaba K, Bloy N, Garcia P, Bordenave C, Martins I, Stoll G, Tesniere A, Kroemer G, Senovilla L (2018) Immune effectors responsible for the elimination of hyperploid cancer cells. Oncoimmunology 7:e1463947

Article  PubMed  PubMed Central  Google Scholar 

Archetti M (2022) Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer. Int J Mol Sci 23(15):8528

Article  PubMed  PubMed Central  Google Scholar 

Ashcroft P, Michor F, Galla T (2015) Stochastic tunneling and metastable states during the somatic evolution of cancer. Genetics 199:1213–1228

Article  PubMed  PubMed Central  Google Scholar 

Atilla-Gokcumen GE, Castoreno AB, Sasse S, Eggert US (2010) Making the cut: the chemical biology of cytokinesis. ACS Chem Biol 5:79–90

Article  CAS  PubMed  PubMed Central  Google Scholar 

Austria T, Marion C, Yu V, Widschwendter M, Hinton DR, Dubeau L (2018) Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways. Int J Cancer 143:2932–2942

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aylon Y, Oren M (2011) p53: guardian of ploidy. Mol Oncol 5:315–323

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai J, Wioland H, Advedissian T, Cuvelier F, Romet-Lemonne G, Echard A (2020) Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy. Proc Natl Acad Sci U S A 117:4169–4179

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balachandran RS, Kipreos ET (2017) Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage. Mol Cell Oncol 4:e1277293

Article  PubMed  PubMed Central  Google Scholar 

Barrio-Alonso E, Hernandez-Vivanco A, Walton CC, Perea G, Frade JM (2018) Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons. Sci Rep 8:14316

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barriuso D, Alvarez-Frutos L, Gonzalez-Gutierrez L, Motiño O, Kroemer G, Palacios-Ramirez R, Senovilla L (2023) Involvement of Bcl-2 family proteins in tetraploidization-related senescence. Int J Mol Sci 24:6374

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baudoin NC, Nicholson JM, Soto K, Martin O, Chen J, Cimini D (2020) Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells. Elife 9:e54565

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beisaw A, Wu CC (2024) Cardiomyocyte maturation and its reversal during cardiac regeneration. Dev Dyn 253:8–27

Article  CAS  PubMed  Google Scholar 

Bernhard SV, Seget-Trzensiok K, Kuffer C, Krastev DB, Stautmeister LM, Theis M, Keuper K, Boekenkamp JE, Kschischo M, Buchholz F, Storchova Z (2022) Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling. Cell Oncol (Dordr) 45:103–119

Article  CAS  PubMed  Google Scholar 

Bernhard SV, Gemble S, Basto R, Storchova Z (2023) Experimental approaches to generate and isolate human tetraploid cells. Polyploidy: Methods and Protocols. Springer, pp 391–399. https://doi.org/10.1007/978-1-0716-2561-3_20

Blagosklonny MV (2006) Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis. Cell Cycle 5:971–975

Article  CAS  PubMed  Google Scholar 

Bloomfield M, Cimini D (2023) The fate of extra centrosomes in newly formed tetraploid cells: should I stay, or should I go? Front Cell Dev Biol 11:1210983

Article  PubMed  PubMed Central  Google Scholar 

Bloy N, Sauvat A, Chaba K, Buque A, Humeau J, Bravo-San Pedro JM, Bui J, Kepp O, Kroemer G, Senovilla L (2015) Morphometric analysis of immunoselection against hyperploid cancer cells. Oncotarget 6:41204–41215

Article  PubMed  PubMed Central  Google Scholar 

Boileve A, Senovilla L, Vitale I, Lissa D, Martins I, Metivier D, van den Brink S, Clevers H, Galluzzi L, Castedo M, Kroemer G (2013) Immunosurveillance against tetraploidization-induced colon tumorigenesis. Cell Cycle 12:473–479

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boissy P, Saltel F, Bouniol C, Jurdic P, Machuca-Gayet I (2002) Transcriptional activity of nuclei in multinucleated osteoclasts and its modulation by calcitonin. Endocrinology 143:1913–1921

Article  CAS  PubMed  Google Scholar 

Borel F, Lohez OD, Lacroix FB, Margolis RL (2002) Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells. Proc Natl Acad Sci U S A 99:9819–9824

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brito DA, Rieder CL (2006) Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol 16:1194–1200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buddell T, Purdy AL, Patterson M (2024) The genetics of cardiomyocyte polyploidy. Curr Top Dev Biol 156:245–295

Article  PubMed  Google Scholar 

Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, Offterdinger M, Pizzato M, Schmidt A, Villunger A (2021) Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26. EMBO J 40:e104844

Article  CAS  PubMed  Google Scholar 

Buttner S, Carmona-Gutierrez D, Vitale I, Castedo M, Ruli D, Eisenberg T, Kroemer G, Madeo F (2007) Depletion of endonuclease G selectively kills polyploid cells. Cell Cycle 6:1072–1076

Article  PubMed  Google Scholar 

Cadart C, Heald R (2022) Scaling of biosynthesis and metabolism with cell size. Mol Biol Cell 33:pe5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canman JC, Hoffman DB, Salmon ED (2000) The role of pre- and post-anaphase microtubules in the cytokinesis phase of the cell cycle. Curr Biol 10:611–614