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SCI Abstract
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Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury
OBJECTIVE: ASPP1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor of p53 to...
Circulation Research
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Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency
BACKGROUND: NOTCH1 pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic ...
Circulation Research
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RyR2 Serine-2030 PKA Site Governs Ca2+ Release Termination and Ca2+ Alternans
Background: PKA (protein kinase A)–mediated phosphorylation of cardiac RyR2 (ryanodine receptor 2) has been extensively st...
Circulation Research
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Flavonifractor plautii Protects Against Elevated Arterial Stiffness
BACKGROUND: Dysbiosis of gut microbiota plays a pivotal role in vascular dysfunction and microbial diversity was reported ...
Circulation Research
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Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure
BACKGROUND: Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of ...
Circulation Research
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NDRG1 Signaling is Essential for Endothelial Inflammation and Vascular Remodeling
BACKGROUND: NDRG-1 (N-myc downstream-regulated gene 1) is a member of NDRG family that plays essential roles in cell diffe...
Circulation Research
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LLPS of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening
BACKGROUND: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in response to various environmental cue...
Circulation Research
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Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart
BACKGROUND: Organ fibrosis due to excessive production of extracellular matrix by resident fibroblasts is estimated to con...
Circulation Research
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Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes
BACKGROUND: We examined components of systemic and intestinal renin-angiotensin system on gut barrier permeability, glucos...
Circulation Research
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Late-Breaking Basic Science Abstracts From the American Heart Association’s Scientific Sessions 2022
© American Heart Association, Inc. All rights reserved. Unauthorized ...
Circulation Research
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Fishing Out the Role of RBPMS2 in Cardiac Splicing
Neil C. Chi Correspondence to: Neil C. Chi, MD, PhD, Department of Medicine, Division of Cardiology, University of Califor...
Circulation Research
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Peering into the Molecular Machinery for Regulation of Cav1.2 Channel Clusters
Thomas J. Hund Correspondence to: Thomas J. Hund, PhD, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio St...
Circulation Research
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Prohibiting MG53 Phosphorylation Optimizes its Therapeutic Potential in Diabetes
Long-Sheng Song Correspondence to: Long-Sheng Song, MD, FAHA, FISHR Department of Internal Medicine, Carver College of Med...
Circulation Research
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Tropoelastin Improves Post-Infarct Cardiac Function by Increasing Scar Elastin
BACKGROUND: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocyt...
Circulation Research
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Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling
Yang K. Xiang Correspondence to: Yang K. Xiang. Email E-mail Address: [email protected] https://orcid.org/0000-0003-1786...
Circulation Research
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TXNIP Suppresses the Osteochondrogenic Switch of VSMCs in Atherosclerosis
BACKGROUND: The osteochondrogenic switch of vascular smooth muscle cells (VSMCs) is a pivotal cellular process in atherosc...
Circulation Research
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Praliciguat Promotes Ischemic Leg Reperfusion on Leptin Receptor-Deficient Mice
BACKGROUND: Lower-limb peripheral artery disease is one of the major complications of diabetes. Peripheral artery disease ...
Circulation Research
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Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression
BACKGROUND: Excess cholesterol accumulation in lesional macrophages elicits complex responses in atherosclerosis. Epsins, ...
Circulation Research
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RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene exp...
Circulation Research
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Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinic...
Circulation Research
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Persisting Platelet Activation and Hyperactivity in COVID-19 Survivors
Jairo Ramos Temerozo https://orcid.org/0000-0002-8092-2149 Laboratory of Immunopharmacology, Oswaldo Cruz Institute, FIOC...
Circulation Research
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Correction to: Gut dysbiosis promotes preeclampsia by regulating macrophages and trophoblasts
© American Heart Association, Inc. All rights reserved. Unauthorized ...
Circulation Research
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In Memoriam Tribute to Jeffrey Robbins, PhD (1950–2022)
Sakthivel Sadayappan Correspondence to: Sakthivel Sadayappan, PhD, MBA, Department of Internal Medicine, Division of Cardi...
Circulation Research
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PCSK9 Pleiotropism: In the Same Vein as Statins
Babak Razani Correspondence to: Babak Razani, MD, PhD, University of Pittsburgh School of Medicine and University of Pitts...
Circulation Research
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Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification
BACKGROUND Vascular calcification is closely related to the all-cause mortality of cardiovascular events. Basement membran...
Circulation Research
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Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation
BACKGROUND: L-type CaV1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. ...
Circulation Research
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The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans
BACKGROUND: Neurovascular coupling (NVC) is a key process in cerebral blood flow regulation. NVC ensures adequate brain pe...
Circulation Research
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Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury
BACKGROUND: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotec...
Circulation Research
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The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis
BACKGROUND: Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 an...
Circulation Research
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Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling
Background: In large-scale genomic studies, Sox17, an endothelial-specific transcription factor, has been suggested as a p...
Circulation Research
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