J Ghith and G Rodriguez are full-time employees of Pfizer Inc. O Evuarherhe is a full-time employee of Oxford PharmaGenesis. A Morgans has received consultancy honoraria from AAA, Astellas Pharma Inc., AstraZeneca, Bayer, Dendreon, Exelixis, Lantheus, Janssen, Myovant, Myriad Genetics, Novartis, Pfizer Inc., Sanofi and Telix, and research funding from Astellas Pharma Inc., Bayer, Myovant, Pfizer Inc. and Sanofi. L Sutton, M Labriola, S Moneer and L Moore have nothing to disclose. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.