Siegel, R. L., Miller, K. D., Wagle, N. S. & Jemal, A. Cancer statistics, 2023. CA Cancer J. Clin. 73, 17–48 (2023).

Article  PubMed  Google Scholar 

Moreira, D. M. et al. Predicting time from metastasis to overall survival in castration-resistant prostate cancer: results from SEARCH. Clin. Genitourin. Cancer 15, 60–66. e62 (2017).

Article  PubMed  Google Scholar 

Chen, X., Comish, P. B., Tang, D. & Kang, R. Characteristics and biomarkers of ferroptosis. Front. Cell Dev. Biol. 9, 637162 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Yang, W. S. et al. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc. Natl Acad. Sci. USA 113, E4966–E4975 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin, Z. et al. The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis. Nat. Commun. 13, 7965 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Catala, A. Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Chem. Phys. Lipids 157, 1–11 (2009).

Article  CAS  PubMed  Google Scholar 

Gao, M. et al. Role of mitochondria in ferroptosis. Mol. Cell 73, 354–363 e353 (2019).

Article  CAS  PubMed  Google Scholar 

Park, M. W. et al. NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases. Redox Biol. 41, 101947 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan, B. et al. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol. Cell 81, 355–369 e310 (2021).

Article  CAS  PubMed  Google Scholar 

Zhang, S. et al. Double-edge sword roles of iron in driving energy production versus instigating ferroptosis. Cell Death Dis. 13, 40 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

von Krusenstiern, A. N. et al. Identification of essential sites of lipid peroxidation in ferroptosis. Nat. Chem. Biol. 19, 719–730 (2023).

Article  Google Scholar 

Yang, W. S. & Stockwell, B. R. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 26, 165–176 (2016).

Article  CAS  PubMed  Google Scholar 

Conrad, M. & Friedmann Angeli, J. P. Glutathione peroxidase 4 (Gpx4) and ferroptosis: what’s so special about it? Mol. Cell Oncol. 2, e995047 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Lu, S. C. Glutathione synthesis. Biochim. Biophys. Acta 1830, 3143–3153 (2013).

Article  CAS  PubMed  Google Scholar 

Du, Y. & Guo, Z. Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discov. 8, 501 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, Q. et al. Understanding sorafenib-induced ferroptosis and resistance mechanisms: implications for cancer therapy. Eur. J. Pharmacol. 955, 175913 (2023).

Article  CAS  PubMed  Google Scholar 

Friedmann Angeli, J. P. et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16, 1180–1191 (2014).

Article  CAS  PubMed  Google Scholar 

Yan, H. F. et al. Ferroptosis: mechanisms and links with diseases. Signal. Transduct. Target. Ther. 6, 49 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao, C. et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 593, 586–590 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cirilli, I. et al. Role of coenzyme Q10 in health and disease: an update on the last 10 years (2010–2020). Antioxidants 10, 1325 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bentinger, M., Tekle, M. & Dallner, G. Coenzyme Q — biosynthesis and functions. Biochem. Biophys. Res. Commun. 396, 74–79 (2010).

Article  CAS  PubMed  Google Scholar 

Kraft, V. A. N. et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent. Sci. 6, 41–53 (2020).

Article  CAS  PubMed  Google Scholar 

Lei, G., Zhuang, L. & Gan, B. Targeting ferroptosis as a vulnerability in cancer. Nat. Rev. Cancer 22, 381–396 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon, S. J. et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife 3, e02523 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Jeong, S. D. et al. Enhanced immunogenic cell death by apoptosis/ferroptosis hybrid pathway potentiates PD-L1 blockade cancer immunotherapy. ACS Biomater. Sci. Eng. 8, 5188–5198 (2022).

Article  CAS  PubMed  Google Scholar 

Lei, G. et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res. 30, 146–162 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viswanathan, V. S. et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547, 453–457 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tousignant, K. D. et al. Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer. Cancer Metab. 8, 11 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Ghoochani, A. et al. Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer. Cancer Res. 81, 1583–1594 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, Y. et al. Ferroptosis inducer erastin downregulates androgen receptor and its splice variants in castration-resistant prostate cancer. Oncol. Rep. 45, 25 (2021).

Article  PubMed  Google Scholar 

Mathur, D. et al. PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition. Cancer Discov. 7, 380–390 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv, Z. et al. Identifying a ferroptosis-related gene signature for predicting biochemical recurrence of prostate cancer. Front. Cell Dev. Biol. 9, 666025 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Mao, C., Liu, X., Yan, Y., Olszewski, K. & Gan, B. Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature 619, E19–E23 (2023).

Article  CAS  PubMed  Google Scholar 

Mishima, E. et al. DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature 619, E9–E18 (2023).

Article  CAS  PubMed  Google Scholar 

Yoo, S. E. et al. Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free. Radic. Biol. Med. 52, 1820–1827 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei, J., Webb, S., Zhang, B. & Shu, H. B. The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression. Oncogene 25, 849–856 (2006).

Article  CAS  PubMed  Google Scholar 

Doll, S. et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat. Chem. Biol. 13, 91–98 (2017).

Article  CAS  PubMed  Google Scholar