Managing the Patient with Psoriasis and Metabolic Comorbidities

Gisondi P, Bellinato F, Girolomoni G, Albanesi C. Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities. Front Pharmacol. 2020;11:117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gisondi P, Fostini AC, Fossà I, Girolomoni G, Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol. 2018;36(1):21–8.

Article  PubMed  Google Scholar 

Langan SM, Seminara NM, Shin DB, et al. Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom. J Investig Dermatol. 2012;132(3):556–62.

Article  CAS  PubMed  Google Scholar 

Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies. J Am Acad Dermatol. 2013;68(4):654–62.

Article  PubMed  Google Scholar 

Norden A, Rekhtman S, Strunk A, Garg A. Risk of psoriasis according to body mass index: a retrospective cohort analysis. J Am Acad Dermatol. 2022;86(5):1020–6.

Article  PubMed  Google Scholar 

Castaldo G, Rastrelli L, Galdo G, Molettieri P, Rotondi Aufiero F, Cereda E. Aggressive weight-loss program with a ketogenic induction phase for the treatment of chronic plaque psoriasis: a proof-of-concept, single-arm, open-label clinical trial. Nutrition. 2020;74: 110757. https://doi.org/10.1016/j.nut.2020.110757.

Article  CAS  PubMed  Google Scholar 

Ogawa K, Stuart PE, Tsoi LC, et al. A transethnic Mendelian randomization study identifies causality of obesity on risk of psoriasis. J Investig Dermatol. 2019;139(6):1397–400. https://doi.org/10.1016/j.jid.2018.11.023.

Article  CAS  PubMed  Google Scholar 

Budu-Aggrey A, Brumpton B, Tyrrell J, et al. Evidence of a causal relationship between body mass index and psoriasis: a Mendelian randomization study. PLoS Med. 2019;16(1): e1002739. https://doi.org/10.1371/journal.pmed.1002739.

Article  PubMed  PubMed Central  Google Scholar 

Gisondi P, Del Giglio M, Di Francesco V, Zamboni M, Girolomoni G. Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial. Am J Clin Nutr. 2008;88(5):1242–7. https://doi.org/10.3945/ajcn.2008.26427.

Article  CAS  PubMed  Google Scholar 

Phan C, Sigal ML, Lhafa M, et al. Metabolic comorbidities and hypertension in psoriasis patients in France: comparisons with French national databases. Ann Dermatol Venereol. 2016;143(4):264–74. https://doi.org/10.1016/j.annder.2015.06.024.

Article  CAS  PubMed  Google Scholar 

Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens. 2013;31(3):433–42. https://doi.org/10.1097/HJH.0b013e32835bcce1. (discussion 442–3).

Article  CAS  PubMed  Google Scholar 

Hu MY, Yang Q, Zheng J. The association of psoriasis and hypertension: focusing on anti-inflammatory therapies and immunological mechanisms. Clin Exp Dermatol. 2020;45(7):836–40. https://doi.org/10.1111/ced.14327.

Article  CAS  PubMed  Google Scholar 

Tablazon IL, Al-Dabagh A, Davis SA, Feldman SR. Risk of cardiovascular disorders in psoriasis patients: current and future. Am J Clin Dermatol. 2013;14(1):1–7. https://doi.org/10.1007/s40257-012-0005-5. (PMID: 23329076).

Article  PubMed  Google Scholar 

Binazzi M, Calandra P, Lisi P. Statistical association between psoriasis and diabetes: further results. Arch Dermatol Res. 1975;254(1):43–8.

Article  CAS  PubMed  Google Scholar 

Brownstein MH. Psoriasis and diabetes mellitus. Arch Dermatol. 1966;93(6):654–5.

Article  CAS  PubMed  Google Scholar 

Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and the risk of diabetes mellitus: a systematic review and meta-analysis. JAMA Dermatol. 2013;149(1):84–91. https://doi.org/10.1001/2013.jamadermatol.406.

Article  PubMed  Google Scholar 

Coto-Segura P, Eiris-Salvado N, González-Lara L, et al. Psoriasis, psoriatic arthritis and type 2 diabetes mellitus: a systematic review and meta-analysis. Br J Dermatol. 2013;169(4):783–93. https://doi.org/10.1111/bjd.12473.

Article  CAS  PubMed  Google Scholar 

Yuan Z, Guo Y. Risk of incident type 2 diabetes in patients with psoriatic arthritis: a systematic review and meta-analysis of cohort studies. Int J Rheum Dis. 2022;25(9):1029–37. https://doi.org/10.1111/1756-185X.14375.

Article  PubMed  Google Scholar 

Ma C, Harskamp CT, Armstrong EJ, Armstrong AW. The association between psoriasis and dyslipidaemia: a systematic review. Br J Dermatol. 2013;168(3):486–95. https://doi.org/10.1111/bjd.12101.

Article  CAS  PubMed  Google Scholar 

Wu S, Li WQ, Han J, Sun Q, Qureshi AA. Hypercholesterolemia and risk of incident psoriasis and psoriatic arthritis in US women. Arthritis Rheumatol. 2014;66(2):304–10. https://doi.org/10.1002/art.38227.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang ZYO, Jian ZY, Tang Y, Li W. The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysis. Front Immunol. 2023;14:1174998. https://doi.org/10.3389/fimmu.2023.1174998.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellinato F, Gisondi P, Mantovani A, Girolomoni G, Targher G. Risk of non-alcoholic fatty disease in patients with chronic plaque psoriasis: an updated systematic review and meta-analysis of observational studies. J Endocrinol Investig. 2022;45(7):1277–88. https://doi.org/10.1007/s40618-022-01755-0.

Article  CAS  Google Scholar 

Wan J, Wang S, Haynes K, Denburg MR, Shin DB, Gelfand JM. Risk of moderate to advanced kidney disease in patients with psoriasis: population based cohort study. BMJ. 2013;347: f5961. https://doi.org/10.1136/bmj.f5961.

Article  PubMed  PubMed Central  Google Scholar 

Ungprasert P, Raksasuk S. Psoriasis and risk of incident chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis. Int Urol Nephrol. 2018;50(7):1277–83. https://doi.org/10.1007/s11255-018-1868-z.

Article  PubMed  Google Scholar 

Bellinato F, Gisondi P, Girolomoni G. Risk of lymphohematologic malignancies in patients with chronic plaque psoriasis: a systematic review with meta-analysis. J Am Acad Dermatol. 2022;86(1):86–96. https://doi.org/10.1016/j.jaad.2021.07.050.

Article  PubMed  Google Scholar 

Lu Y, Chen H, Nikamo P, et al. Association of cardiovascular and metabolic disease genes with psoriasis. J Investig Dermatol. 2013;133(3):836–9. https://doi.org/10.1038/jid.2012.366.

Article  CAS  PubMed  Google Scholar 

Patrick MT, Stuart PE, Zhang H, et al. Causal relationship and shared genetic loci between psoriasis and type 2 diabetes through trans-disease meta-analysis. J Investig Dermatol. 2021;141(6):1493–502. https://doi.org/10.1016/j.jid.2020.11.025.

Article  CAS  PubMed  Google Scholar 

Mehta NN, Teague HL, Swindell WR, et al. IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis. Sci Rep. 2017;7(1):13831. https://doi.org/10.1038/s41598-017-14365-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rose S, Stansky E, Dagur PK, et al. Characterization of immune cells in psoriatic adipose tissue. J Transl Med. 2014;12(1):258. https://doi.org/10.1186/s12967-014-0258-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gisondi P, Lora V, Bonauguri C, Russo A, Lippi G, Girolomoni G. Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. Br J Dermatol. 2013;168(4):749–55.

Article  CAS  PubMed  Google Scholar 

Davidovici BB, Sattar N, Prinz JC, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Investig Dermatol. 2010;130(7):1785–96. https://doi.org/10.1038/jid.2010.103.

Article  CAS  PubMed  Google Scholar 

Eder L, Jayakar J, Pollock R, et al. Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity. Ann Rheum Dis. 2013;72(12):1956–61. https://doi.org/10.1136/annrheumdis-2012-202325.

Article  CAS  PubMed  Google Scholar 

Mantovani A, Gisondi P, Lonardo A, Targher G. Relationship between non-alcoholic Fatty liver disease and psoriasis: a novel hepato-dermal axis? Int J Mol Sci. 2016;17(2):217. https://doi.org/10.3390/ijms17020217.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torres T, Bettencourt N, Mendonça D, et al. Epicardial adipose tissue and coronary artery calcification in psoriasis patients. J Eur Acad Dermatol Venereol. 2015;29(2):270–7.

Article  CAS  PubMed 

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