Sex-dependent associations of serum BDNF, glycolipid metabolism and cognitive impairments in Parkinson’s disease with depression: a comprehensive analysis

Aarsland D, Bronnick K, Williams-Gray C, Weintraub D, Marder K, Kulisevsky J, Burn D, Barone P, Pagonabarraga J, Allcock L, Santangelo G, Foltynie T, Janvin C, Larsen JP, Barker RA, Emre M (2010) Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology 75(12):1062–1069. https://doi.org/10.1212/WNL.0b013e3181f39d0e

Article  CAS  PubMed  PubMed Central  Google Scholar 

Accolla E, Caputo E, Cogiamanian F, Tamma F, Mrakic-Sposta S, Marceglia S, Egidi M, Rampini P, Locatelli M, Priori A (2007) Gender differences in patients with Parkinson’s disease treated with subthalamic deep brain stimulation. Mov Disord 22(8):1150–1156. https://doi.org/10.1002/mds.21520

Article  PubMed  Google Scholar 

Alomari MA, Khalil H, Khabour OF, Alzoubi KH (2022) Lipid profile in Parkinson’s disease: The potential role of brain-derived neurotrophic factor. Life Sci 311(Pt A) 121144. https://doi.org/10.1016/j.lfs.2022.121144

Althaus A, Becker OA, Spottke A, Dengler R, Schneider F, Kloss M, Eggert K, Oertel WH, Dillmann U, Herting B, Classen J, Dodel R (2008) Frequency and treatment of depressive symptoms in a Parkinson’s disease registry. Parkinsonism Relat Disord 14(8):626–632. https://doi.org/10.1016/j.parkreldis.2008.01.016

Article  PubMed  Google Scholar 

Augustine EF, Pérez A, Dhall R, Umeh CC, Videnovic A, Cambi F, Wills AM, Elm JJ, Zweig RM, Shulman LM, Nance MA, Bainbridge J, Suchowersky O (2015) Sex differences in Clinical Features of Early, treated Parkinson’s Disease. PLoS ONE 10(7):e0133002. https://doi.org/10.1371/journal.pone.0133002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64(2):238–258. https://doi.org/10.1124/pr.111.005108

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bakeberg MC, Jefferson A, Riley M, Byrnes M, Ghosh S, Mastaglia FL, Horne MK, McGregor S, Stell R, Kenna J, Walters S, Hince D, Anderton RS (2019) Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease. Parkinsons Dis 2019(3124295). https://doi.org/10.1155/2019/3124295

Bakeberg MC, Riley M, Byrnes M, Jefferson A, Ghosh S, Horne MK, McGregor S, Stell R, Walters S, Evans T, Roberts K, Mastaglia FL, Anderton RS (2020) Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease. Parkinsons Dis 2020:8296203. https://doi.org/10.1155/2020/8296203

Bakeberg MC, Gorecki AM, Kenna JE, Jefferson A, Byrnes M, Ghosh S, Horne MK, McGregor S, Stell R, Walters S, Mastaglia FL, Anderton RS (2021) Elevated HDL levels linked to poorer cognitive ability in females with Parkinson’s Disease. Front Aging Neurosci 13:656623. https://doi.org/10.3389/fnagi.2021.656623

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bakeberg MC, Gorecki AM, Kenna JE, Jefferson A, Byrnes M, Ghosh S, Horne MK, McGregor S, Stell R, Walters S, Chivers P, Winter SJ, Mastaglia FL, Anderton RS (2021a) Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson’s disease. J Neurol 268(5):1903–1912. https://doi.org/10.1007/s00415-020-10367-8

Article  PubMed  PubMed Central  Google Scholar 

Bech P (2015) The responsiveness of the different versions of the Hamilton Depression Scale. World Psychiatry 14(3):309–310. https://doi.org/10.1002/wps.20248

Article  PubMed  PubMed Central  Google Scholar 

Benítez-Castañeda A, Anaya-Martínez V, Espadas-Alvarez AJ, Gutierrez-Váldez AL, Razgado-Hernández LF, Reyna-Velazquez PE, Quintero-Macias L, Martínez-Fong D, Florán-Garduño B, Aceves J (2024) Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease. Parkinsons Dis 2024(3885451). https://doi.org/10.1155/2024/3885451

Berk M, Köhler-Forsberg O, Turner M, Penninx BWJH, Wrobel A, Firth J, Loughman A, Reavley NJ, McGrath JJ, Momen NC, Plana-Ripoll O, O’Neil A, Siskind D, Williams LJ, Carvalho AF, Schmaal L, Walker AJ, Dean O, Walder K, Berk L, Dodd S, Yung AR, Marx W (2023) Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management. World Psychiatry 22(3):366–387. https://doi.org/10.1002/wps.21110

Article  PubMed  PubMed Central  Google Scholar 

Bloem BR, Okun MS, Klein C (2021) Parkinson’s disease. Lancet 397(10291):2284–2303. https://doi.org/10.1016/S0140-6736(21)00218-X

Article  CAS  PubMed  Google Scholar 

Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen MG, Placentino A, Giovannini C, Rillosi L, Ventriglia M, Riva MA, Gennarelli M (2010) Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 11(6):763–773. https://doi.org/10.3109/15622971003611319

Article  PubMed  Google Scholar 

Buhmann C, Dogac S, Vettorazzi E, Hidding U, Gerloff C, Jürgens TP (2017) The impact of Parkinson disease on patients’ sexuality and relationship. J Neural Transm (Vienna) 124(8):983–996. https://doi.org/10.1007/s00702-016-1649-8

Article  CAS  PubMed  Google Scholar 

Carrarini C, Russo M, Dono F, Di Pietro M, Rispoli MG, Di Stefano V, Ferri L, Barbone F, Vitale M, Thomas A, Sensi SL, Onofrj M, Bonanni L (2019) A stage-based Approach to Therapy in Parkinson’s Disease. Biomolecules 9(8):388. https://doi.org/10.3390/biom9080388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casiglia E, Tikhonoff V, Caffi S, Bascelli A, Schiavon L, Guidotti F, Saugo M, Giacomazzo M, Martini B, Mazza A, D’este D, Pessina AC (2008) Menopause does not affect blood pressure and risk profile, and menopausal women do not become similar to men. J Hypertens 26(10):1983–1992. https://doi.org/10.1097/HJH.0b013e32830bfdd9

Article  CAS  PubMed  Google Scholar 

Castrén E (2003) Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 4(1):58–64. https://doi.org/10.1016/j.coph.2003.10.004

Article  CAS  Google Scholar 

Celik C, Balikci A, Ozdemir B, Oznur T (2016) BDNF and other biological markers are associated with schizophrenia onset and positive symptoms: a different approach. Schizophr Res 175(1–3):232. https://doi.org/10.1016/j.schres.2016.05.005

Article  PubMed  Google Scholar 

Cerri S, Mus L, Blandini F (2019) Parkinson’s Disease in women and men: what’s the difference? J Parkinsons Dis 9(3):501–515. https://doi.org/10.3233/JPD-191683

Article  PubMed  PubMed Central  Google Scholar 

Chandran S, Krishnan S, Rao RM, Sarma SG, Sarma PS, Kishore A (2014) Gender influence on selection and outcome of deep brain stimulation for Parkinson’s disease. Ann Indian Acad Neurol 17(1):66–70. https://doi.org/10.4103/0972-2327.128557

Article  PubMed  PubMed Central  Google Scholar 

Chen Z, Zhang H (2023) A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson’s disease patients. Adv Clin Exp Med 32(3):285–295. https://doi.org/10.17219/acem/154955

Article  PubMed  Google Scholar 

Chiara P, Roberta Z, Elena S, Brigida M, Ilaria B, Claudio P (2013) Cognitive function in Parkinson’s disease: the influence of gender. Basal Ganglia 3(2):131–135. https://doi.org/10.1016/j.baga.2012.10.004

Article  Google Scholar 

Chmiela T, Węgrzynek J, Kasprzyk A, Waksmundzki D, Wilczek D, Gorzkowska A (2022) If not insulin resistance so what? - Comparison of fasting glycemia in idiopathic Parkinson’s disease and atypical parkinsonism. Diabetes Metab Syndr Obes 9(15):1451–1460. https://doi.org/10.2147/DMSO.S359856

Cholerton B, Johnson CO, Fish B, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Hu SC, Mata IF, Leverenz JB, Poston KL, Montine TJ, Zabetian CP, Edwards KL (2018) Sex differences in progression to mild cognitive impairment and dementia in Parkinson’s disease. Parkinsonism Relat Disord 50:29–36. https://doi.org/10.1016/j.parkreldis.2018.02.007

Article  PubMed  PubMed Central  Google Scholar 

Clark US, Neargarder S, Cronin-Golomb A (2008) Specific impairments in the recognition of emotional facial expressions in Parkinson’s disease. Neuropsychologia 46(9):2300–2309. https://doi.org/10.1016/j.neuropsychologia.2008.03.014

Article  PubMed  PubMed Central  Google Scholar 

Cubo E, Bernard B, Leurgans S, Raman R (2000) Cognitive and motor function in patients with Parkinson’s disease with and without depression. Clin Neuropharmacol 23(6):331–334. https://doi.org/10.1097/00002826-200011000-00006

Article  CAS  PubMed  Google Scholar 

Dan X, Wang C, Zhang J, Gu Z, Zhou Y, Ma J, Chan P (2016) Association between common genetic risk variants and depression in Parkinson’s disease: a dPD study in Chinese. Parkinsonism Relat Disord 33:122–126. https://doi.org/10.1016/j.parkreldis.2016.09.029

Article  PubMed  Google Scholar 

Davidsdottir S, Cronin-Golomb A, Lee A (2005) Visual and spatial symptoms in Parkinson’s disease. Vis Res 45(10):1285–1296. https://doi.org/10.1016/j.visres.2004.11.006

Article  PubMed  Google Scholar 

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