Bloem BR, Okun MS, Klein C (2021) Parkinson’s disease. Lancet 397(10291):2284–2303. https://doi.org/10.1016/s0140-6736(21)00218-x
Article CAS PubMed Google Scholar
Tolosa E, Garrido A, Scholz SW, Poewe W (2021) Challenges in the diagnosis of Parkinson’s disease. Lancet Neurol 20(5):385–397. https://doi.org/10.1016/s1474-4422(21)00030-2
Article CAS PubMed PubMed Central Google Scholar
Ascherio A, Schwarzschild MA (2016) The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol 15(12):1257–1272. https://doi.org/10.1016/s1474-4422(16)30230-7
Church FC (2021) Treatment options for motor and non-motor symptoms of Parkinson’s disease. Biomolecules 11(4):612. https://doi.org/10.3390/biom11040612
Reich SG, Savitt JM (2019) Parkinson’s disease. Med Clin North Am 103(2):337–350. https://doi.org/10.1016/j.mcna.2018.10.014
Hussein A, Guevara CA, Del Valle P, Gupta S, Benson DL, Huntley GW (2021) Non-motor symptoms of Parkinson’s disease: the neurobiology of early psychiatric and cognitive dysfunction. Neuroscientist 29(1):97–116. https://doi.org/10.1177/10738584211011979
Article CAS PubMed PubMed Central Google Scholar
Schapira AHV, Chaudhuri KR, Jenner P (2017) Non-motor features of Parkinson disease. Nat Rev Neurosci 18(7):435–450. https://doi.org/10.1038/nrn.2017.62
Article CAS PubMed Google Scholar
Dickson DW (2018) Neuropathology of Parkinson disease. Parkinsonism Relat Disord 46:S30–S33. https://doi.org/10.1016/j.parkreldis.2017.07.033
Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ (2021) Mitochondrial dysfunction and mitophagy in Parkinson’s disease: from mechanism to therapy. Trends Biochem Sci 46(4):329–343. https://doi.org/10.1016/j.tibs.2020.11.007
Article CAS PubMed Google Scholar
Dionísio PA, Amaral JD, Rodrigues CMP (2021) Oxidative stress and regulated cell death in Parkinson’s disease. Ageing Res Rev 67:101263. https://doi.org/10.1016/j.arr.2021.101263
Article CAS PubMed Google Scholar
Wang T, Shi C, Luo H, Zheng H, Fan L, Tang M et al (2021) Neuroinflammation in Parkinson’s disease: triggers, mechanisms, and immunotherapies. Neuroscientist 28(4):364–381. https://doi.org/10.1177/1073858421991066
Article CAS PubMed Google Scholar
Jankovic J, Tan EK (2020) Parkinson’s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry 91(8):795–808. https://doi.org/10.1136/jnnp-2019-322338
Badanjak K, Fixemer S, Smajić S, Skupin A, Grünewald A (2021) The contribution of microglia to neuroinflammation in Parkinson’s Disease. Int J Mol Sci 22(9):4676. https://doi.org/10.3390/ijms22094676
Article CAS PubMed PubMed Central Google Scholar
Isik S, YemanKiyak B, Akbayir R, Seyhali R, Arpaci T (2023) Microglia mediated neuroinflammation in Parkinson’s Disease. Cells 12(7):1012. https://doi.org/10.3390/cells12071012
Article CAS PubMed PubMed Central Google Scholar
Palumbo L, Carinci M, Guarino A, Asth L, Zucchini S, Missiroli S et al (2023) The NLRP3 inflammasome in neurodegenerative disorders: insights from epileptic models. Biomedicines 11(10):2825. https://doi.org/10.3390/biomedicines11102825
Article CAS PubMed PubMed Central Google Scholar
Anderson FL, Biggs KE, Rankin BE, Havrda MC (2023) NLRP3 inflammasome in neurodegenerative disease. Transl Res 252:21–33. https://doi.org/10.1016/j.trsl.2022.08.006
Article CAS PubMed Google Scholar
Picca A, Faitg J, Auwerx J, Ferrucci L, D’Amico D (2023) Mitophagy in human health, ageing and disease. Nat Metab 5(12):2047–2061. https://doi.org/10.1038/s42255-023-00930-8
Lou G, Palikaras K, Lautrup S, Scheibye-Knudsen M, Tavernarakis N, Fang EF (2020) Mitophagy and neuroprotection. Trends Mol Med 26(1):8–20. https://doi.org/10.1016/j.molmed.2019.07.002
Article CAS PubMed Google Scholar
Madsen DA, Schmidt SI, Blaabjerg M, Meyer M (2021) Interaction between Parkin and α-Synuclein in PARK2-Mediated Parkinson’s Disease. Cells 10(2):283. https://doi.org/10.3390/cells10020283
Article CAS PubMed PubMed Central Google Scholar
Fang T-SZ, Sun Y, Pearce AC, Eleuteri S, Kemp M, Luckhurst CA et al (2023) Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model. Nat Commun 14(1):7295. https://doi.org/10.1038/s41467-023-42876-1
Article CAS PubMed PubMed Central Google Scholar
Matheoud D, Sugiura A, Bellemare-Pelletier A, Laplante A, Rondeau C, Chemali M et al (2016) Parkinson’s disease-related proteins PINK1 and Parkin repress mitochondrial antigen presentation. Cell 166(2):314–327. https://doi.org/10.1016/j.cell.2016.05.039
Article CAS PubMed Google Scholar
Walsh TG, van den Bosch MTJ, Lewis KE, Williams CM, Poole AW (2018) Loss of the mitochondrial kinase PINK1 does not alter platelet function. Sci Rep 8(1):14377. https://doi.org/10.1038/s41598-018-32716-4
Article CAS PubMed PubMed Central Google Scholar
Braun MM, Puglielli L (2022) Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseases. Front Cell Neurosci 16:1031153. https://doi.org/10.3389/fncel.2022.1031153
Article CAS PubMed PubMed Central Google Scholar
Pickrell AM, Youle RJ (2015) The roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson’s disease. Neuron 85(2):257–273. https://doi.org/10.1016/j.neuron.2014.12.007
Article CAS PubMed PubMed Central Google Scholar
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K et al (2022) DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain 145(12):4368–4384. https://doi.org/10.1093/brain/awac313
Article PubMed PubMed Central Google Scholar
Liu H, Ho PW-L, Leung C-T, Pang SY-Y, Chang EES, Choi ZY-K et al (2020) Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441Gmice. Autophagy 17(10):3196–3220. https://doi.org/10.1080/15548627.2020.1850008
Article CAS PubMed PubMed Central Google Scholar
Franco R, Hatori Y, Kanda Y, Nonaka S, Nakanishi H, Kitazawa T (2022) ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway. Plos One 17(11):e0276823. https://doi.org/10.1371/journal.pone.0276823
Eldeeb MA, Thomas RA, Ragheb MA, Fallahi A, Fon EA (2022) Mitochondrial quality control in health and in Parkinson’s disease. Physiol Rev 102(4):1721–1755. https://doi.org/10.1152/physrev.00041.2021
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