Liu T, Jin Q, Yang L, et al. Regulation of autophagy by natural polyphenols in the treatment of diabetic kidney disease: therapeutic potential and mechanism. Front Endocrinol (Lausanne). 2023;14:1142276.

Article  PubMed  Google Scholar 

Szablewski L. Insulin resistance: the increased risk of cancers. Curr Oncol. 2024;31:998–1027.

Article  PubMed  PubMed Central  Google Scholar 

Wang LH, Wang YY, Liu L, Gong Q. From diabetes to diabetic complications: role of autophagy. Curr Med Sci. 2023;43:434–44.

Article  PubMed  Google Scholar 

Yang X, Feng P, Ji R, Ren Y, Wei W, Holscher C. Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease. Expert Opin Ther Targets. 2022;26:445–60.

Article  CAS  PubMed  Google Scholar 

Nowell J, Blunt E, Gupta D, Edison P. Antidiabetic agents as a novel treatment for Alzheimer’s and Parkinson’s disease. Ageing Res Rev. 2023;89: 101979.

Article  CAS  PubMed  Google Scholar 

Zheng W, Zhou J, Song S, et al. Dipeptidyl-peptidase 4 inhibitor sitagliptin ameliorates hepatic insulin resistance by modulating inflammation and autophagy in ob/ob mice. Int J Endocrinol. 2018;2018:8309723.

Article  PubMed  PubMed Central  Google Scholar 

Canet F, Diaz-Pozo P, Luna-Marco C, et al. Mitochondrial redox impairment and enhanced autophagy in peripheral blood mononuclear cells from type 1 diabetic patients. Redox Biol. 2022;58: 102551.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sakai S, Yamamoto T, Takabatake Y, et al. Proximal tubule autophagy differs in type 1 and 2 diabetes. J Am Soc Nephrol. 2019;30:929–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu M, Chen W, Zhang S, et al. Rotenone protects against β-cell apoptosis and attenuates type 1 diabetes mellitus. Apoptosis. 2019;24:879–91.

Article  CAS  PubMed  Google Scholar 

Du X, Di Malta C, Fang Z, et al. Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway. Acta Pharm Sin B. 2022;12:2869–86.

Article  CAS  PubMed  Google Scholar 

Hu H, Yin JH, Shao DD, et al. The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation. Eur Rev Med Pharmacol Sci. 2020;24:10028–35.

CAS  PubMed  Google Scholar 

Liu H, Javaheri A, Godar RJ, et al. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy. 2017;13:1952–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parikh HM, Elgzyri T, Alibegovic A, et al. Relationship between insulin sensitivity and gene expression in human skeletal muscle. BMC Endocr Disord. 2021;21:32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qian Q, Zhang Z, Li M, et al. Hepatic lysosomal iNOS activity impairs autophagy in obesity. Cell Mol Gastroenterol Hepatol. 2019;8:95–110.

Article  PubMed  PubMed Central  Google Scholar 

Tran D, Myers S, McGowan C, et al. 1-deoxysphingolipids, early predictors of type 2 diabetes, compromise the functionality of skeletal myoblasts. Front Endocrinol (Lausanne). 2021;12: 772925.

Article  PubMed  Google Scholar 

Wu T, Shao Y, Li X, et al. NR3C1/glucocorticoid receptor activation promotes pancreatic β-cell autophagy overload in response to glucolipotoxicity. Autophagy. 2023;19:2538–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji J, Tao P, Wang Q, Li L, Xu Y. SIRT1: mechanism and protective effect in diabetic nephropathy. Endocr Metab Immune Disord Drug Targets. 2021;21:835–42.

CAS  PubMed  Google Scholar 

Jaikumkao K, Thongnak L, Htun KT, et al. Dapagliflozin and metformin in combination ameliorates diabetic nephropathy by suppressing oxidative stress, inflammation, and apoptosis and activating autophagy in diabetic rats. Biochim Biophys Acta Mol Basis Dis. 2024;1870: 166912.

Article  CAS  PubMed  Google Scholar 

Guo L, Tan K, Luo Q, Bai X. Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. Bosn J Basic Med Sci. 2020;20:372–80.

CAS  PubMed  PubMed Central  Google Scholar 

Wu J, Chen Y, Shi S, et al. Exploration of pharmacological mechanisms of dapagliflozin against type 2 diabetes mellitus through PI3K-Akt signaling pathway based on network pharmacology analysis and deep learning technology. Curr Comput Aided Drug Des. 2024. https://doi.org/10.2174/0115734099274407231207070451. (Online ahead of print).

Article  PubMed  Google Scholar 

Khater SI, El-Emam MMA, Abdellatif H, et al. Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: the interplay between oxidative stress—unfolded protein response (UPR)—autophagy, and their regulatory miRNA. Life Sci. 2024;344: 122546.

Article  CAS  PubMed  Google Scholar 

Li A, Yi B, Han H, et al. Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway. Autophagy. 2022;18:877–90.

Article  CAS  PubMed  Google Scholar 

Li F, Chen Y, Li Y, Huang M, Zhao W. Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway. Eur J Pharmacol. 2020;886: 173449.

Article  CAS  PubMed  Google Scholar 

Takagaki Y, Lee SM, Dongqing Z, Kitada M, Kanasaki K, Koya D. Endothelial autophagy deficiency induces IL6—dependent endothelial mesenchymal transition and organ fibrosis. Autophagy. 2020;16:1905–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan J, Li X, Liu N, He JC, Zhong Y. Relationship between macrophages and tissue microenvironments in diabetic kidneys. Biomedicines. 2023;11:1889.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao J, Chen J, Zhu W, Qi XM, Wu YG. Exosomal miR-7002-5p derived from highglucose-induced macrophages suppresses autophagy in tubular epithelial cells by targeting Atg9b. FASEB J. 2022;36: e22501.

Article  CAS  PubMed  Google Scholar 

Zhu X, Xu X, Du C, et al. An examination of the protective effects and molecular mechanisms of curcumin, a polyphenol curcuminoid in diabetic nephropathy. Biomed Pharmacother. 2022;153: 113438.

Article  CAS  PubMed  Google Scholar 

Yu J, Liu Y, Li H, Zhang P. Pathophysiology of diabetic kidney disease and autophagy: a review. Medicine (Baltimore). 2023;102: e33965.

Article  CAS  PubMed  Google Scholar 

E Y, Lin Y, Yan G, et al. Exogenous H(2)S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice. Biochim Biophys Acta Mol Cell Res. 2023;1870: 119568.

Article  CAS  PubMed  Google Scholar 

Lee WC, Chiu CH, Chen JB, Chen CH, Chang HW. Mitochondrial fission increases apoptosis and decreases autophagy in renal proximal tubular epithelial cells treated with high glucose. DNA Cell Biol. 2016;35:657–65.

Article  CAS  PubMed