Bruneau BG (2008) The developmental genetics of congenital heart disease. Nature 451:943–948. https://doi.org/10.1038/nature06801
Article PubMed CAS Google Scholar
Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S, Wareham NJ (2023) Causal associations between cardiorespiratory fitness and type 2 diabetes. Nat Commun 14:3904. https://doi.org/10.1038/s41467-023-38234-w
Article PubMed PubMed Central CAS Google Scholar
Cargnoni A, Ceconi C, Stavroula G, Ferrari R (2006) Heart rate reduction by pharmacological if current inhibition. Adv Cardiol 43:31–44. https://doi.org/10.1159/000095404
Article PubMed CAS Google Scholar
Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low S-K, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen L-P, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng L-C, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen Y-DI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N et al (2017) Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet 49:946–952. https://doi.org/10.1038/ng.3843
Article PubMed PubMed Central CAS Google Scholar
den Hoed M, Eijgelsheim M, Esko T, Brundel BJJM, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra H-J, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan Ja, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O’Reilly PF, Padmanabhan S, St. Pourcain B, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HHM, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PIW, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Dörr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJC, Goyette P, Gudnason V, Harris TB, Hartikainen A-L, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga J-J, Jensen MK, Johansson Å, Junttila J, Kääb S, Kanon B, Ketkar S, Khaw K-T, Knowles JW, Kooner AS et al (2013) Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics 45: 621–631. https://doi.org/10.1038/ng.2610
Derrick CJ, Pollitt EJG, Sanchez Sevilla Uruchurtu A, Hussein F, Grierson AJ, Noël ES (2021) Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development 148. https://doi.org/10.1242/dev.199691
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PIW, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJC, Estrada K, Hwang S-J, Bis JC, Rückert I-M, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JCM, Psaty BM, Wichmann H-E, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BHC, Boerwinkle E, O’Donnell CJ (2010) Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet 19:3885–3894. https://doi.org/10.1093/hmg/ddq303
Article PubMed PubMed Central CAS Google Scholar
Eppinga RN, Hagemeijer Y, Burgess S, Hinds DA, Stefansson K, Gudbjartsson DF, van Veldhuisen DJ, Munroe PB, Verweij N, van der Harst P (2016) Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality. Nat Genet 48:1557–1563. https://doi.org/10.1038/ng.3708
Article PubMed CAS Google Scholar
Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, Gunnarsdottir K, Helgason A, Oddsson A, Halldorsson BV, Jensson BO, Zink F, Halldorsson GH, Masson G, Arnadottir GA, Katrinardottir H, Juliusson K, Magnusson MK, Magnusson OT, Fridriksdottir R, Saevarsdottir S, Gudjonsson SA, Stacey SN, Rognvaldsson S, Eiriksdottir T, Olafsdottir TA, Steinthorsdottir V, Tragante V, Ulfarsson MO, Stefansson H, Jonsdottir I, Holm H, Rafnar T, Melsted P, Saemundsdottir J, Norddahl GL, Lund SH, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53:1712–1721. https://doi.org/10.1038/s41588-021-00978-w
Article PubMed CAS Google Scholar
Finan C, Gaulton A, Kruger FA, Lumbers RT, Shah T, Engmann J, Galver L, Kelley R, Karlsson A, Santos R, Overington JP, Hingorani AD, Casas JP (2017) The druggable genome and support for target identification and validation in drug development. Sci Transl Med 9:eaag1166. https://doi.org/10.1126/scitranslmed.aag1166
Article PubMed PubMed Central CAS Google Scholar
Fourbon Y, Guéguinou M, Félix R, Constantin B, Uguen A, Fromont G, Lajoie L, Magaud C, Lecomte T, Chamorey E, Chatelier A, Mignen O, Potier-Cartereau M, Chantôme A, Bois P, Vandier C (2017) Ca2 + protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. Sci Rep 7:14199. https://doi.org/10.1038/s41598-017-14230-1
Article PubMed PubMed Central CAS Google Scholar
Gazal S, Weissbrod O, Hormozdiari F, Dey KK, Nasser J, Jagadeesh KA, Weiner DJ, Shi H, Fulco CP, O’Connor LJ, Pasaniuc B, Engreitz JM, Price AL (2022) Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity. Nat Genet 54:827–836. https://doi.org/10.1038/s41588-022-01087-y
Article PubMed PubMed Central CAS Google Scholar
Gerull B, Brodehl A (2020) Genetic animal models for Arrhythmogenic Cardiomyopathy. Front Physiol 11. https://doi.org/10.3389/fphys.2020.00624
Giusti B, Marini M, Rossi L, Lapini I, Magi A, Capalbo A, Lapalombella R, di Tullio S, Samaja M, Esposito F, Margonato V, Boddi M, Abbate R, Veicsteinas A (2009) Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection. BMC Genomics 10:342. https://doi.org/10.1186/1471-2164-10-342
Article PubMed PubMed Central CAS Google Scholar
Guo Y, Chung W, Zhu Z, Shan Z, Li J, Liu S, Liang L (2019) Genome-wide Assessment for resting Heart Rate and Shared Genetics with Cardiometabolic traits and Type 2 diabetes. J Am Coll Cardiol 74:2162–2174. https://doi.org/10.1016/j.jacc.2019.08.1055
Article PubMed CAS Google Scholar
Haag TA, Haag NP, Lekven AC, Hartenstein V (1999) The role of cell adhesion molecules inDrosophilaHeart morphogenesis:faint sausage, Shotgun/DE-Cadherin, andLaminin AAre required for Discrete stages in Heart Development. Dev Biol 208:56–69. https://doi.org/10.1006/dbio.1998.9188
Article PubMed CAS Google Scholar
Harrow J, Frankish A, Gonzalez JM, Tapanari E, Diekhans M, Kokocinski F, Aken BL, Barrell D, Zadissa A, Searle S, Barnes I, Bignell A, Boychenko V, Hunt T, Kay M, Mukherjee G, Rajan J, Despacio-Reyes G, Saunders G, Steward C, Harte R, Lin M, Howald C, Tanzer A, Derrien T, Chrast J, Walters N, Balasubramanian S, Pei B, Tress M, Rodriguez JM, Ezkurdia I, van Baren J, Brent M, Haussler D, Kellis M, Valencia A, Reymond A, Gerstein M, Guigó R, Hubbard TJ (2012) GENCODE: the reference human genome annotation for the ENCODE Project. Genome Res 22:1760–1774. https://doi.org/10.1101/gr.135350.111
Article PubMed PubMed Central CAS Google Scholar
Hay JC, Hirling H, Scheller RH (1996) Mammalian vesicle trafficking proteins of the endoplasmic reticulum and golgi apparatus (∗). J Biol Chem 271:5671–5679. https://doi.org/10.1074/jbc.271.10.5671
Article PubMed CAS Google Scholar
Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, Bhattacharjee MB, Arimura K, Umehara F, Izumo S, Northrop JL, Salih MA, Inoue K, Armstrong DL, Champoux JJ, Takashima H, Boerkoel CF (2007) Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? EMBO J 26:4732–4743. https://doi.org/10.1038/sj.emboj.7601885
Article PubMed PubMed Central CAS Google Scholar
Hoefle ML, Blouin LT, Fleming RW, Hastings S, Hinkley JM, Mertz TE, Steffe TJ, Stratton CS, Werbel LM (1991) Synthesis and antiarrhythmic activity of.alpha.-[(diarylmethoxy)methyl]-1-piperidineethanols. J Med Chem 34:7–12. https://doi.org/10.1021/jm00105a002
Article PubMed CAS Google Scholar
Hoogenhof MMGvd, Beqqali A, Amin AS, Made Ivd, Aufiero S, Khan MAF, Schumacher CA, Jansweijer JA, Spaendonck-Zwarts KYv, Remme CA, Backs J, Verkerk AO, Baartscheer A, Pinto YM, Creemers EE (2018) RBM20 mutations induce an arrhythmogenic dilated cardiomyopathy related to disturbed Calcium Handling. Circulation 138:1330–1342. https://doi.org/10.1161/CIRCULATIONAHA.117.031947
Article PubMed CAS Google Scholar
Hung C-H, Liu K-S, Shao D-Z, Cheng K-I, Chen Y-C, Chen Y-W (2010) The systemic toxicity of Equipotent Proxymetacaine, Oxybuprocaine, and Bupivacaine during continuous intravenous infusion in rats. Anesth Analgesia 110:238–242. https://doi.org/10.1213/ANE.0b013e3181bf6acf
Jagadeesh KA, Dey KK, Montoro DT, Mohan R, Gazal S, Engreitz JM, Xavier RJ, Price AL, Regev A (2022) Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics. Nat Genet 54:1479–1492. https://doi.org/10.1038/s41588-022-01187-9
Article PubMed PubMed Central CAS Google Scholar
Jung I, Schmitt A, Diao Y, Lee AJ, Liu T, Yang D, Tan C, Eom J, Chan M, Chee S, Chiang Z, Kim C, Masliah E, Barr CL, Li B, Kuan S, Kim D, Ren B (2019) A compendium of promoter-centered long-range chromatin interactions in the human genome. Nat Genet 51:1442–1449.
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