Chetter IC, Carradice D  (2018) Venous disorders In: Williams NS, O’Connell PR, McCaskie AW editor. Bailey and Love’s short practice of surgery. 27th edition. Boca Raton, FL: CRC Press; Chapter 57:969–94

Malhotra SL (1972) An epidemiological study of varicose veins in Indian railroad workers from the South and North of India, with special reference to the causation and prevention of varicose veins. Int J Epid 1:177–183. https://doi.org/10.1093/ije/1.2.177

Article  CAS  Google Scholar 

Raetz J, Wilson M, Collins K (2019) Varicose veins: diagnosis and treatment. Am Fam Physician 99:682–8. https://www.aafp.org/pubs/afp/issues/2019/0601/p682.html. Accessed 17 Apr 2023

Mansilha A, Sousa J (2018) Pathophysiological mechanisms of chronic venous disease and implications for venoactive drug therapy. Int J Mol Sci 19:1669. https://doi.org/10.3390/ijms19061669

Article  CAS  PubMed  Google Scholar 

Khobragade KJ, Patil CS, Borkar NE (2019) Clinical efficacy of concurrent therapy with oral FDC tablet of Euphorbia prostrata plus calcium dobesilate and topical FDC cream of Euphorbia prostrata plus lidocaine in the management of haemorrhoids: a prospective, open-label multicentric study. Int J Med Health Sci 8:63–71

CAS  Google Scholar 

Gawas M, Bains A, Janghu S et al (2022) A comprehensive review on varicose veins: preventive measures and different treatments. J Am Nutr Assoc 41:499–510. https://doi.org/10.1080/07315724.2021.1909510

Article  CAS  PubMed  Google Scholar 

Tejerina T, Ruiz E (1998) Calcium dobesilate: pharmacology and future approaches. Gen Pharmacol 31:357–360. https://doi.org/10.1016/s0306-3623(98)00040-8

Article  CAS  PubMed  Google Scholar 

Yetkin E, Ozturk S (2018) Dilating vascular diseases: pathophysiology and clinical aspects. Int J Vasc Med 2018:9024278. https://doi.org/10.1155/2018/9024278

Article  CAS  PubMed  Google Scholar 

Paty J, Turner-Bowker DM, Elash CA, Wright D (2016) The VVSymQ® instrument: use of a new patient-reported outcome measure for assessment of varicose vein symptoms. Phlebology 31:481–488. https://doi.org/10.1177/0268355515595193

Article  PubMed  Google Scholar 

Vasquez MA, Wang J, Mahathanaruk M et al (2007) The utility of the venous clinical severity score in 682 limbs treated by radiofrequency saphenous vein ablation. J Vasc Surg 45:1008–1014. https://doi.org/10.1016/j.jvs.2006.12.061. (discussion 1015)

Article  PubMed  Google Scholar 

Sadek M, Pergamo M, Almeida JI, Jacobowitz GR, Kabnick LS (2021) An algorithm combining VVSYmQ® and VCSS scores may help to predict disease severity in C2 patients. Phlebology 36:809–815. https://doi.org/10.1177/02683555211023306

Article  PubMed  Google Scholar 

Todd KL 3rd, Wright DI; VANISH-2 Investigator Group (2015) Durability of treatment effect with polidocanol endovenous microfoam on varicose vein symptoms and appearance (VANISH-2). J Vasc Surg Venous Lymphat Disord 3:258-264.e1. https://doi.org/10.1016/j.jvsv.2015.03.003

Article  Google Scholar 

Arceo A, Berber A, Treviño C (2002) Clinical evaluation of the efficacy and safety of calcium dobesilate in patients with chronic venous insufficiency of the lower limbs. Angiology 53:539–544. https://doi.org/10.1177/000331970205300506

Article  PubMed  Google Scholar 

Kaur C, Sarkar R, Kanwar AJ et al (2003) An open trial of calcium dobesilate in patients with venous ulcers and stasis dermatitis. Int J Dermatol 42:147–152. https://doi.org/10.1046/j.1365-4362.2003.01709.x

Article  CAS  PubMed  Google Scholar 

Ciapponi A, Laffaire E, Roqué M (2004) Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology 55:147–154. https://doi.org/10.1177/000331970405500206

Article  PubMed  Google Scholar 

Rabe E, Jaeger KA, Bulitta M, Pannier F (2011) Calcium dobesilate in patients suffering from chronic venous insufficiency: a double-blind, placebo-controlled, clinical trial. Phlebology 26:162–168. https://doi.org/10.1258/phleb.2010.010051

Article  CAS  PubMed  Google Scholar 

Rabe E, Ballarini S, Lehr L, Doxium EDX09/01 Study Group (2016) A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. Phlebology 31:264–274. https://doi.org/10.1177/0268355515586097

Article  PubMed  Google Scholar 

Yalvac ESD, Demiroğlu M, Gursel S, Aydin E (2018) Calcium dobesilate versus micronised purified flavonoid fraction of diosmin in the treatment of chronic venous disease: a randomized prospective study. Acta Medica Mediterranea 34:657–661. https://doi.org/10.19193/0393-6384_2018_3_101

Article  Google Scholar 

Perera N, Liolitsa D, Iype S et al (2012) Phlebotonics for haemorrhoids. Cochrane Database Syst Rev 8:CD004322. https://doi.org/10.1002/14651858.CD004322.pub3

Article  Google Scholar 

Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D et al (2020) Phlebotonics for venous insufficiency. Cochrane Database Syst Rev 11:CD003229. https://doi.org/10.1002/14651858.CD003229.pub4

Article  PubMed  Google Scholar 

Yetkin E, Ileri M (2016) Dilating venous disease: pathophysiology and a systematic aspect to different vascular territories. Med Hypotheses 91:73–76. https://doi.org/10.1016/j.mehy.2016.04.016

Article  PubMed  Google Scholar 

Yetkin E, Ozturk S, Cuglan B, Turhan H (2020) Symptoms in dilating venous disease. Curr Cardiol Rev 16:164–172. https://doi.org/10.2174/1573403X16666200312101245

Article  CAS  PubMed  Google Scholar 

Piazza G (2014) Varicose veins. Circulation 130:582–527. https://doi.org/10.1161/CIRCULATIONAHA.113.008331

Article  PubMed  Google Scholar 

Joseph N, Abhishai B, FaizanThouseef M et al (2016) A multicenter review of epidemiology and management of varicose veins for national guidance. Ann Med Surg (Lond) 8:21–27. https://doi.org/10.1016/j.amsu.2016.04.024

Eberhardt RT, Raffetto JD (2005) Chronic venous insufficiency. Circulation 111:2398–2409. https://doi.org/10.1161/01.CIR.0000164199.72440.08

Article  PubMed  Google Scholar 

Antani MR, Dattilo JB (2023) Varicose veins. [Updated 2022 Nov 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Available from: https://www.ncbi.nlm.nih.gov/books/NBK470194/. Accessed 17 Apr 2023

De Maeseneer MG, Kakkos SK, Aherne T et al (2022) Editor’s Choice - European Society for Vascular Surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs [published correction appears in Eur J Vasc Endovasc Surg 64:284–285]. Eur J Vasc Endovasc Surg 63:184–267. https://doi.org/10.1016/j.ejvs.2021.12.024

Article  PubMed  Google Scholar