Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J. Autism spectrum disorder. Lancet. 2018;392:508–20.
Article PubMed PubMed Central Google Scholar
Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, et al. Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveill Summ. 2018;67:1–23.
Article PubMed PubMed Central Google Scholar
Maenner MJ, Shaw KA, Baio J, Washington A, Patrick M, DiRienzo M, et al. Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2016. MMWR Surveill Summ. 2020;69:1–12.
Article PubMed PubMed Central Google Scholar
Zhou H, Xu X, Yan W, Zou X, Wu L, Luo X, et al. Prevalence of autism spectrum disorder in China: a nationwide multi-center population-based study among children aged 6–12 years. Neurosci Bull. 2020;36:961–71.
Article PubMed PubMed Central Google Scholar
Emberti Gialloreti L, Mazzone L, Benvenuto A, Fasano A, Alcon AG, Kraneveld A, et al. Risk and protective environmental factors associated with autism spectrum disorder: evidence-based principles and recommendations. J Clin Med. 2019;8:217.
Article PubMed PubMed Central Google Scholar
Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, et al. Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiat. 2019;76:1035–43.
Idring S, Magnusson C, Lundberg M, Ek M, Rai D, Svensson AC, et al. Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort. Int J Epidemiol. 2014;43:107–15.
Christensen J, Gronborg TK, Sorensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA. 2013;309:1696–703.
Article CAS PubMed PubMed Central Google Scholar
Lyall K, Ashwood P, Water J, Hertzicciotto I. Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay. J Autism Dev Disord. 2014;44:1546–55.
PubMed PubMed Central Google Scholar
Schmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, et al. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr. 2012;96:80–9.
Article CAS PubMed PubMed Central Google Scholar
Schmidt RJ, Iosif AM, Guerrero Angel E, Ozonoff S. Association of maternal prenatal vitamin use with risk for autism spectrum disorder recurrence in young siblings. JAMA Psychiat. 2019;76:391–8.
Li Q, Yang T, Chen L, Dai Y, Wu LJ, Jia FY, et al. Serum folate status is primarily associated with neurodevelopment in children with autism spectrum disorders aged three and under-a multi-center study in China. Front Nutr. 2021;8:661223.
Article PubMed PubMed Central Google Scholar
Qi X, Yang T, Chen J, Dai Y, Chen L, Wu L, et al. Vitamin D status is primarily associated with core symptoms in children with autism spectrum disorder: a multicenter study in China. Psychiatry Res. 2022;317:114807.
Article CAS PubMed Google Scholar
Yang T, Chen L, Dai Y, Jia F, Hao Y, Li L, et al. Vitamin A status is more commonly associated with symptoms and neurodevelopment in boys with autism spectrum disorders-a multicenter study in China. Front Nutr. 2022;9:851980.
Article PubMed PubMed Central Google Scholar
Liu Z, Wang J, Xu Q, Hong Q, Zhu J, Chi X. Research progress in vitamin A and autism spectrum disorder. Behav Neurol. 2021;2021:5417497.
PubMed PubMed Central Google Scholar
Bates CJ. Vitamin A. Lancet. 1995;345:31–5.
Article CAS PubMed Google Scholar
Zieger E, Schubert M. New insights into the roles of retinoic acid signaling in nervous system development and the establishment of neurotransmitter systems. Int Rev Cell Mol Biol. 2017;330:1–84.
Article CAS PubMed Google Scholar
Kane MA, Folias AE, Wang C, Napoli JL. Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry. Anal Chem. 2008;80:1702–8.
Article CAS PubMed PubMed Central Google Scholar
Ghyselinck NB, Duester G. Retinoic acid signaling pathways. Development. 2019;146:167502.
Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci. 2007;8:755–65.
Article CAS PubMed Google Scholar
Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, et al. Regulation of prefrontal patterning and connectivity by retinoic acid. Nature. 2021;598:483–8.
Article CAS PubMed PubMed Central Google Scholar
Liu H, Tan M, Cheng B, Wang S, Xiao L, Zhu J, et al. Valproic acid induces autism-like synaptic and behavioral deficits by disrupting histone acetylation of prefrontal cortex ALDH1A1 in rats. Front Neurosci. 2021;15:641284.
Article PubMed PubMed Central Google Scholar
Guerra M, Medici V, Weatheritt R, Corvino V, Palacios D, Geloso MC, et al. Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum. Transl Psychiatry. 2023;13:114.
Article CAS PubMed PubMed Central Google Scholar
Hao Z, Wu Q, Li Z, Li Y, Li Q, Lai X, et al. Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders. Cell Res. 2019;29:866–9.
Article CAS PubMed PubMed Central Google Scholar
Wu Q, Yang T, Chen L, Dai Y, Wei H, Jia F, et al. Early life exposure to triclosan from antimicrobial daily necessities may increase the potential risk of autism spectrum disorder: a multicenter study in China. Ecotoxicol Environ Saf. 2022;247:114197.
Article CAS PubMed Google Scholar
Xu X, Li C, Gao X, Xia K, Guo H, Li Y, et al. Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. Cell Res. 2018;28:48–68.
Article CAS PubMed Google Scholar
Lai X, Zhang Q, Zhu J, Yang T, Guo M, Li Q, et al. A weekly vitamin A supplementary program alleviates social impairment in Chinese children with autism spectrum disorders and vitamin A deficiency. Eur J Clin Nutr. 2021;75:1118–25.
Article CAS PubMed Google Scholar
Zhou W, Li S. Decreased levels of serum retinoic acid in chinese children with autism spectrum disorder. Psychiatry Res. 2018;269:469–73.
Article CAS PubMed Google Scholar
Pavăl D, Rad F, Rusu R, Niculae AS, Colosi HA, Dobrescu I, et al. Low retinal dehydrogenase 1 (RALDH1) level in prepubertal boys with autism spectrum disorder: a possible link to dopamine dysfunction? Clin Psychopharmacol Neurosci. 2017;15:229–36.
Article PubMed PubMed Central Google Scholar
Moreno-Ramos OA, Olivares AM, Haider NB, de Autismo LC, Lattig MC. Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and retinoic acid regulation pathways to autism spectrum disorders. PLoS One. 2015;10:e0135927.
Article PubMed PubMed Central Google Scholar
Nelson RH. Autism advocacy before and after DSM-5. Am J Bioeth. 2020;20:48–50.
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