Whitlock G, Lewington S, Sherliker P et al (2009) Prospective Studies Collaboration. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373:1083–1096
Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579–591
Article CAS PubMed Google Scholar
Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121:2111–2117
Article CAS PubMed PubMed Central Google Scholar
Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781–810
Article CAS PubMed Google Scholar
Gordon MD, Nusse R (2006) Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281:22429–22433
Article CAS PubMed Google Scholar
Barchetta I, CiminiCapoccia FA et al (2017) WISP1 is a marker of systemic and adipose tissue inflammation in dysmetabolic subjects with or without type 2 diabetes. J Endocr Soc 1:660–670
Article CAS PubMed PubMed Central Google Scholar
Wang AR, Yan XQ, Zhang C, Du CQ, Long WJ, Zhan D, Ren J, Luo XP (2018) Characterization of Wnt1-inducible signaling pathway protein-1 in obese children and adolescents. Curr Med Sci 38:868–874
Article CAS PubMed Google Scholar
Jung TW, Kang C, Goh J, Chae SI, Kim H-C, Lee TJ, Abd El-Aty AM, Jeong JH (2018) WISP1 promotes non-alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling. J Cell Physiol 233:6077–6087
Article CAS PubMed Google Scholar
Klimontov VV, Bulumbaeva DM, Fazullina ON, Lykov AP, Bgatova NP, Orlov NB, Konenkov VI, Pfeiffer AFH, Pivovarova-Ramich O, Rudovich N (2020) Circulating Wnt1-inducible signaling pathway protein-1 (WISP-1/CCN4) is a novel biomarker of adiposity in subjects with type 2 diabetes. J Cell Commun Signal 14:101–109
Schauer PR, Bhatt DL, Kirwan JP et al (2017) Bariatric surgery versus intensive medical therapy for diabetes -5-year outcomes. N Engl J Med 376(7):641–651
Article PubMed PubMed Central Google Scholar
Buchwald H, Buchwald JN (2019) Metabolic (bariatric and nonbariatric) surgery for type 2 diabetes: a personal perspective review. Diabetes Care 42(2):331–340
Aroda VR (2018) A review of GLP-1 receptor agonists: evolution and advancement, through the lens of randomised controlled trials. Diabetes Obes Metab 20(Supplement 1):22–33
Article CAS PubMed Google Scholar
Jirapinyo P, Jin DX, Qazi T, Mishra N, Thompson CC (2018) A meta-analysis of GLP-1 after Roux-en-Y gastric bypass: impact of surgical technique and measurement strategy. Obes Surg 28(3):615–626
Ye J, Hao Z, Mumphrey MB (2014) Mumphrey et al. “GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents. Am J Physiol 306(5):R352–R362
Wilson-Pérez HE, Chambers AP, Ryan KK et al (2013) Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like peptide 1 receptor deficiency. Diabetes 62(7):2380–2385
Article PubMed PubMed Central Google Scholar
Andrew CA, Umashanker D, Aronne LJ, Shukla AP (2018) Intestinal and gastric origins for diabetes resolution after bariatric surgery. Curr Obes Rep 7(2):139–146
Chang JS, Kim TH, Kong ID (2020) Exercise intervention lowers aberrant serum WISP-1 levels with insulin resistance in breast cancer survivors: a randomized controlled trial. Sci Rep 10(1):10898
Article CAS PubMed PubMed Central Google Scholar
Murahovschi V, Pivovarova O, Ilkavets I, Dmitrieva RM, Döcke S, Keyhani-Nejad F, Gögebakan Ö, Osterhoff M, Kemper M, Hornemann S, Markova M, Klöting N, Stockmann M, Weickert MO, Lamounier-Zepter V, Neuhaus P, Konradi A, Dooley S, von Loeffelholz C, Blüher M, Pfeiffer AF, Rudovich N (2015) WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes 64(3):856–866
Article CAS PubMed Google Scholar
Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM (2018) The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes. Diabetologia 61(9):2054–2065
Ferrand N, Bereziat V, Moldes M, Zaoui M, Larsen AK, Sabbah M (2017) WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARγ activity. Sci Rep 7:1749
Article PubMed PubMed Central Google Scholar
Spalding KL, Arner E, Westermark PO et al (2008) Dynamics of fat cell turnover in humans. Nature 453:783–787
Article CAS PubMed Google Scholar
Mirr M, Owecki M (2021) An update to the WISP-1/CCN4 role in obesity, insulin resistance and diabetes. Medicina 57(2):100
Article PubMed PubMed Central Google Scholar
Recarte M, Corripio R, Palma S, Mata A, de Cos AI (2023) Improvement of low-grade inflammation in patients with metabolically healthy severe obesity after primary bariatric surgery. Obes Surg 33(1):38–46
Villarreal-Calderon JR, Cuellar-Tamez R, Castillo EC, Luna-Ceron E, García-Rivas G, Elizondo-Montemayor L (2021) Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery. Sci Rep 11(1):12127
Article CAS PubMed PubMed Central Google Scholar
Wu H, Ballantyne CM (2017) Skeletal muscle inflammation and insulin resistance in obesity. J Clin Invest 127(1):43–54
Article PubMed PubMed Central Google Scholar
Petersen KF et al (2007) The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A 104(31):12587–12594
Article CAS PubMed PubMed Central Google Scholar
Petersen KF, Shulman GI (2002) Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol 90(5A):11G-18G
Article CAS PubMed Google Scholar
Lorenzo M, Fernández-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I (2008) Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes. J Anim Sci 86(14 suppl):E94–E104
Article CAS PubMed Google Scholar
Bouzakri K, Koistinen HA, Zierath JR (2005) Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev 1(2):167–174
Article CAS PubMed Google Scholar
DeFronzo RA, Tripathy D (2009) Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32(suppl 2):S157–S163
Article CAS PubMed PubMed Central Google Scholar
Kaminska B (2009) Molecular characterization of inflammation-induced JNK/c-Jun signaling pathway in connection with tumorigenesis. Methods Mol Biol 512:249–264
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