Antimicrobial photodynamic therapy using gold nanoparticles conjugated with 1,9-dimethyl-methylene blue for treating Staphylococcus skin infections

Rodríguez-Noriega E, Seas C (2010) The changing pattern of methicillin-resistant staphylococcus aureus clones in Latin America: implications for clinical practice in the region. Braz J Infect Dis 14:87–96. https://doi.org/10.1590/s1413-86702010000800004

Article  Google Scholar 

Taylor TA, Unakal CG (2023) Staphylococcus aureus Infection. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 28722898

Vanegas JFB (2019) Rational design and synthesis of macrocyclic peptidomimetics for inhibiting Quorum Sensing in Staphylococcus aureus. Thesis, University of Brasilia

Lin L, Song X, Dong X, Li B (2021) Nano-photosensitizers for enhanced photodynamic therapy. Photodiagnosis Photodyn Ther 36:102597. https://doi.org/10.1016/j.pdpdt.2021.102597

Article  CAS  PubMed  Google Scholar 

Kashef N, Hamblin MR (2017) Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation? Drug Resist Update 31:31–42. https://doi.org/10.1016/j.drup.2017.07.003

Article  Google Scholar 

Valenzuela-Valderrama M, Gonzalez IA, Palavecino CE (2019) Photodynamic treatment for multidrug-resistant Gram-negative bacteria: perspectives for treating Klebsiella pneumoniae infections. Photodiagnosis Photodyn Ther 28:256–264. https://doi.org/10.1016/j.pdpdt.2019.08.012

Article  CAS  PubMed  Google Scholar 

Maisch T (2015) Strategies to optimize photosensitizers for photodynamic inactivation of bacteria. J Photochem Photobiol B 150:2–10. https://doi.org/10.1016/j.jphotobiol.2015.05.010

Article  CAS  Google Scholar 

Wainwright M, Maisch T, Nonell S, Plaetzer K, Almeida A, Tegos GP, Hamblin MR (2017) Photoantimicrobials-are we afraid of the light? Lancet Infect Dis 17:e49–e55. https://doi.org/10.1016/S1473-3099(16)30268-7

Article  PubMed  Google Scholar 

Gursoy H, Ozcakir-Tomruk C, Tanalp J, Yılmaz S (2013) Photodynamic therapy in dentistry: a literature review. Clin Oral Investig 17:1113–1125. https://doi.org/10.1007/s00784-012-0845-7

Article  PubMed  Google Scholar 

Hamblin MR (2016) Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes. Curr Opin Microbiol 33:67–73. https://doi.org/10.1016/j.mib.2016.06.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gollmer A, Felgenträger A, Bäumler W, Maisch T, Späth A (2015) A novel set of symmetric methylene blue derivatives exhibits effective bacteria photokilling — a structure — response study. Photochem Photobiol Sci Photochemical Photobiological Sci 14:335–351. https://doi.org/10.1039/c4pp00309h

Article  CAS  Google Scholar 

Martins WK, Santos NF, Rocha CS, Bacellar IOL, Tsubone TM, Viotto AC, Matsukuma AY, Abrantes ABP, Siani P, Dias LG, Baptista MS (2019) Parallel damage in mitochondria and lysosomes is an efficient way to photoinduce cell death. Autophagy 15:259–279. https://doi.org/10.1080/15548627.2018.1515609

Article  CAS  PubMed  Google Scholar 

Bacellar IO, Tsubone TM, Pavani C, Baptista MS (2015) Photodynamic efficiency: from Molecular Photochemistry to Cell Death. Int J Mol Sci 16:20523–20559. https://doi.org/10.3390/ijms160920523

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos DA, Crugeira PJL, Nunes IPF, de Almeida PF, Pinheiro ALB (2019) A novel technique of antimicrobial photodynamic therapy - aPDT using 1,9-dimethyl methylene blue zinc chloride double salt-DMMB and polarized light on Staphylococcus aureus. J Photochem Photobiol B 200:111646. https://doi.org/10.1016/j.jphotobiol.2019.111646

Article  CAS  PubMed  Google Scholar 

Monteiro JSC, Rangel EE, de Oliveira SCPS, Crugeira PJL, Nunes IPF, Fagnani SRC, Sampaio FJP, de Almeida PF, Pinheiro ALB (2020) Enhancement of photodynamic inactivation of planktonic cultures of Staphylococcus aureus by DMMB-AuNPs. Photodiagnosis Photodyn Ther 31:101930. https://doi.org/10.1016/j.pdpdt.2020.101930

Article  CAS  PubMed  Google Scholar 

Sibani S, McCarron PA, Woolfson AD, Donnelly RF (2008) Photosensitiser delivery for photodynamic therapy. Part 2: systemic carrier platforms. 5:1241–1254. https://doi.org/10.1517/17425240802444673. Expert Opin Drug Deliv

Rosa CHS (2021) Evaluation of the efficiency of photosensitizing nanoparticles for application in photodynamic cancer therapy. Thesis, Federal Technological University of Paraná

Aminabad NS, Farshbaf M, Akbarzadeh A (2018) Recent advances of gold nanoparticles in Biomedical Applications: state of the art. Cell Biochem Biophys 77:123–137. https://doi.org/10.1007/s12013-018-0863-4

Article  CAS  PubMed  Google Scholar 

Fratoddi I, Venditti I, Cametti C, Russo MV (2014) Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges. J Mater Chem B. 2:4204–4220. https://doi.org/10.1039/c4tb00383g

Tawfik AA, Alsharnoubi J, Morsy M (2015) Photodynamic antibacterial enhanced effect of methylene blue-gold nanoparticles conjugate on staphylococcal aureus isolated from impetigo lesions in vitro study. Photodiagn Photodyn Ther 12:215–220. https://doi.org/10.1016/j.pdTFD.2015.03.003

Article  CAS  Google Scholar 

Demidova TN, Hamblin MR (2004) Photodynamic therapy targeted to pathogens. Int J Immunopathol Pharmacol 17:245–254. https://doi.org/10.1177/039463200401700304

Article  CAS  PubMed  Google Scholar 

Oliveira MA, Moreira AC, Ramalho L, Brugnera AJ, Zanin F, Lima TC (2003) Comparative Study of the Effects of the Use of the CO2 Laser and Chlorohexidine on the Healing of Cutaneous Wounds Infected by the Staphylococcus aureus. Mech Low-Light Ther X. Proc SPIE. 4950. https://doi.org/10.1117/12.476441

Madigan MT, Martinko JM, Dunlap PV, Clark DP (2009) Brock biology of microorganisms. Pearson, London

Google Scholar 

Sampaio FJP, Oliveira SCP, Crugeira PJ, Monteiro JSC, Fagnani SRC, Pepe IM, Almeida PF, Pinheiro ALB (2019) TFDA using nanoconcentration of 1,9-dimethylmethylene blue associated to red light is efficacious in killing Enterococcus faecalis ATCC 29212 in vitro. J Photochem Photobiol B 200:111654. https://doi.org/10.1016/j.jphotobiol.2019.111654

Article  CAS  PubMed  Google Scholar 

Perni S, Piccirillo C, Pratten J, Prokopovich P, Chrzanowski W, Parkin IP, Wilson M, Biomaterials (2009) The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 30:89–93. https://doi.org/10.1016/j.biomaterials.2008.09.020

Article  CAS  PubMed  Google Scholar 

Fumes AC, Telles PD, Corona SA, Borsatto MC (2018) Effect of TFDa on Streptococcus mutans and Candida albicans present in the dental biofilm: systematic review. Photodiagn Photodyn Ther 21:363–366. https://doi.org/10.1016/j.pdTFD.2018.01.013

Article  CAS  Google Scholar 

Hamblin MR, Sousa MP, Arany PR, Carroll JD, Patthoff D (2015) Low level laser (light) therapy and photobiomodulation: the path forward. Mech Low-Light Ther X. Proc SPIE 9309:930902. https://doi.org/10.1117/12.2084049

Article  Google Scholar 

Zolfaghari PS, Packer S, Singer M, Nair SP, Bennett J, Street C, Wilson M (2009) In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC Microbiol 9:27. https://doi.org/10.1186/1471-2180-9-27

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tegos GP, Masago K, Aziz F, Higginbotham A, Stermitz FR, Hamblin MR (2008) Inhibitors of bacterial Multidrug Efflux Pumps Potentiate Antimicrobial Photoinactivation. Antimicrob Agents Chemother 52:3202–3209. https://doi.org/10.1128/aac.00006-08

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suresh MK, Biswas R, Biswas L (2019) An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms. Int J Med Microbiol 309:1–12. https://doi.org/10.1016/j.ijmm.2018.11.002

Article  CAS  PubMed  Google Scholar 

Alavi M, Rai M (2019) Recent advances in antibacterial applications of metal nanoparticles (MNPs) and metal nanocomposites (MNCs) against multidrug-resistant (MDR) bacteria. Expert Rev Anti Infect Ther 17:419–428. https://doi.org/10.1080/14787210.2019.1614914

Article  CAS  PubMed  Google Scholar 

Huang W, Tsai P, Chen Y (2007) Functional gold nanoparticles as photothermal agents for selective-killing of pathogenic bacteria. Nanomed 6:777–787. https://doi.org/10.2217/17435889.2.6.777

Article  Google Scholar 

Ricci-Junior E, Marchetti JM (2006) Preparation, characterization, photocytotoxicity assay of PLGA nanoparticles containing zinc (II) phthalocyanine for photodynamic therapy use. J Microencap 23:523–538. https://doi.org/10.1080/02652040600775525

Article  CAS  Google Scholar 

Correia TT da S (2018) In vitro antimicrobial photodynamic inactivation of Candida albicans and Staphylococcus aureus assisted by gold nanoshells. Dissertation. Federal University of Pernambuco

Comments (0)

No login
gif