In the article “DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory,” by Paul R. Marshall, Joshua Davies, Qiongyi Zhao, Wei-Siang Liau, Yujin Lee, Dean Basic, Ambika Periyakaruppiah, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Marcin Kielar, Arie Maeve Brueckner, Hao Gong, Haobin Ren, Alexander Walsh, Lech Kaczmarczyk, Walker S. Jackson, Alon Chen, Robert C. Spitale, and Timothy W. Bredy, which appeared in the April 10, 2024 issue, the authors identified an error in the Discussion section regarding the interpretation of findings from a cited paper (Hanna et al., 2021). The incorrect text appears in the first paragraph of the Discussion section and reads: “In this respect, DHX36 regulates G4-DNA primarily in the TSS and introns in neurons, whereas in immune cells, BMI1 promotes the accumulation of G4-DNA and subsequent regulation of L1-containing transcripts, suggesting that different G4-DNA-related binding proteins may regulate different subregions of the genome (Hanna et al., 2021).”

The authors clarify: “This paper referenced was performed in human fibroblasts and reprogrammed human neurons, not immune cells. The statement was referencing a line deleted during editing.”

The corrected text reads: “In this respect, DHX36 regulates G4-DNA primarily in the TSS and introns in mouse neurons. Previous observations showed that in human dermal fibroblasts and human neurons, BMI1 can reduce G4s at Long Interspersed Element-1 (L1) sequences across the genome (Hanna et al., 2021). Together, this suggests that while different G4-DNA-related binding proteins can bind all regions, whether some of these proteins have an affinity for G4 that occur in certain genomic locations (promoter, TSS, intron) or genomic elements (L1, and other repeats), or if this specificity is interlinked with cellular activity and cell-type is unknown.”

The authors apologize for the error. These changes do not affect the conclusions of the paper, and the online version has been corrected.

https://doi.org/10.1523/JNEUROSCI.0308-25.2025