Vaidyanathan A, Malilay J, Schramm P et al (2020) Heat-related deaths—United States, 2004–2018. Morb Mortal Wkly Rep 69(24):729

Article  Google Scholar 

Pörtner H-O, Roberts DC, Adams H et al (2022) Climate change 2022: Impacts, adaptation and vulnerability: IPCC Geneva, Switzerland

Varghese G, John G, Thomas K et al (2005) Predictors of multi-organ dysfunction in heatstroke. Emerg Med J 22(3):185–187

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang M, Li Z, Zhao Y et al (2017) Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke. Medicine 96(44):e8417

Article  PubMed  PubMed Central  Google Scholar 

McLaughlin CT, Kane AG, Auber AE (2003) MR imaging of heat stroke: external capsule and thalamic T1 shortening and cerebellar injury. Am J Neuroradiol 24(7):1372–1375

PubMed  PubMed Central  Google Scholar 

Albukrek D, Bakon M, Moran D et al (1997) Heat-stroke-induced cerebellar atrophy: clinical course CT and MRI findings. Neuroradiology 39(3):195–197

Article  CAS  PubMed  Google Scholar 

Yaqub B, Daif A, Panayiotopoulos C (1987) Pancerebellar syndrome in heat stroke: clinical course and CT scan findings. Neuroradiology 29(3):294–296

Article  CAS  PubMed  Google Scholar 

Yilmaz TF, Aralasmak A, Toprak H et al (2018) MRI and MR spectroscopy features of heat stroke: a case report. Iran J Radiol 15(3):e62386

Google Scholar 

Kilkenny C, Browne WJ, Cuthill IC et al (2010) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother 1(2):94–99

Article  PubMed  PubMed Central  Google Scholar 

Hagiwara S, Iwasaka H, Shingu C et al (2010) High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Inflamm Res 59(7):511–518

Article  CAS  PubMed  Google Scholar 

Hagiwara S, Iwasaka H, Shingu C et al (2011) Danaparoid sodium attenuates the effects of heat stress. J Surg Res 171(2):762–768

Article  CAS  PubMed  Google Scholar 

Yamakawa K, Matsumoto N, Imamura Y et al (2013) Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model. PLoS ONE 8(2):e56728

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim D, Yoon H-J, Lee WJ et al (2019) Prognostic value of 18F-FDG brain PET as an early indicator of neurological outcomes in a rat model of post-cardiac arrest syndrome. Sci Rep 9(1):14798

Article  PubMed  PubMed Central  Google Scholar 

Kim D, Lee WJ, Lee HW et al (2022) Application of 18F-FDG brain PET for survival prediction in a rat model of hanging-induced hypoxic brain injury. Ann Nucl Med 36(6):570–578

Article  CAS  PubMed  Google Scholar 

Romanovsky AA (2007) Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol-Regul Integr Comp Physiol 292(1):37–46

Article  Google Scholar 

Zhao Z-D, Yang WZ, Gao C et al (2017) A hypothalamic circuit that controls body temperature. Proc Natl Acad Sci 114(8):2042–2047

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S-H, Lin M-T, Chang C-P (2013) Ischemic and oxidative damage to the hypothalamus may be responsible for heat stroke. Curr Neuropharmacol 11(2):129–140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma HS, Hoopes P (2003) Hyperthermia induced pathophysiology of the central nervous system. Int J Hyperth 19(3):325–354

Article  CAS  Google Scholar 

Chen Z-C, Wu W-S, Lin M-T et al (2009) Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke. BMC Neurosci 10:111

Article  PubMed  PubMed Central  Google Scholar 

Chang C-P, Huang W-T, Cheng B-C et al (2007) The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke. Neuropharmacology 52(3):1024–1033

Article  CAS  PubMed  Google Scholar 

Tai P-A, Chang C-K, Niu K-C et al (2021) Attenuation of heat-induced hypothalamic ischemia, inflammation, and damage by hyperbaric oxygen in rats. J Neurotrauma 38(8):1185–1192

Article  PubMed  Google Scholar 

Craig AD, Chen K, Bandy D et al (2000) Thermosensory activation of insular cortex. Nat Neurosci 3(2):184–190

Article  CAS  PubMed  Google Scholar 

Oppenheimer S, Cechetto D (2011) The insular cortex and the regulation of cardiac function. Compr Physiol 6(2):1081–1133

Article  Google Scholar 

Wang L, Liu F, Luo Y et al (2015) Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin-2, interleukin-12 and apoptosis gene expression in rats. Biomed Rep 3(3):425–429

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fushimi Y, Taki H, Kawai H et al (2012) Abnormal hyperintensity in cerebellar efferent pathways on diffusion-weighted imaging in a patient with heat stroke. Clin Radiol 67(4):389–392

Article  CAS  PubMed  Google Scholar 

Ookura R, Shiro Y, Takai T et al (2009) Diffusion-weighted magnetic resonance imaging of a severe heat stroke patient complicated with severe cerebellar ataxia. Intern Med 48(12):1105–1108

Article  PubMed  Google Scholar 

Quinn CM, Duran RM et al (2014) Cardiovascular and thermoregulatory biomarkers of heat stroke severity in a conscious rat model. J Appl Physiol 117(9):971–978

Article  PubMed  Google Scholar