Bomasang-Layno E, Bronsther R (2021) Diagnosis and treatment of Alzheimer’s disease: an update. Delaware J Public Heal 7:74–85. https://doi.org/10.32481/djph.2021.09.009
Kent SA, Spires-Jones TL, Durrant CS (2020) The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics. Acta Neuropathol 140:417–447. https://doi.org/10.1007/S00401-020-02196-W
Article CAS PubMed PubMed Central Google Scholar
Inamdar A, Gurupadayya B, Halagali P et al (2024) Cutting-edge strategies for overcoming therapeutic barriers in Alzheimer’s disease. Curr Pharm Des 31:598–618. https://doi.org/10.2174/0113816128344571241018154506
Yiannopoulou KG, Papageorgiou SG (2020) Current and future treatments in Alzheimer disease: an update. J Cent Nerv Syst Dis 12:1–12. https://doi.org/10.1177/1179573520907397
Livingston G, Huntley J, Sommerlad A et al (2020) Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet 396:413–446. https://doi.org/10.1016/S0140-6736(20)30367-6
Article PubMed PubMed Central Google Scholar
Galle SA, Geraedts IK, Deijen JB et al (2020) The interrelationship between insulin-like growth factor 1, apolipoprotein E ε4, lifestyle factors, and the aging body and brain. J Prev Alzheimer’s Dis 7:265–273. https://doi.org/10.14283/jpad.2020.11
Kumar A, Singh A, Ekavali (2015) A review on Alzheimer’s disease pathophysiology and its management: an update. Pharmacol Rep 67:195–203. https://doi.org/10.1016/j.pharep.2014.09.004
Article CAS PubMed Google Scholar
Seltzer B (2007) Is long-term treatment of Alzheimer’s disease with cholinesterase inhibitor therapy justified? Drugs Aging 24:881–890. https://doi.org/10.2165/00002512-200724110-00001
Article CAS PubMed Google Scholar
Ali TB, Schleret TR, Reilly BM et al (2015) Adverse effects of cholinesterase inhibitors in dementia, according to the pharmacovigilance databases of the United-States and Canada. PLoS One 10:1–10. https://doi.org/10.1371/journal.pone.0144337
Se Thoe E, Fauzi A, Tang YQ et al (2021) A review on advances of treatment modalities for Alzheimer’s disease. Life Sci 276:119129. https://doi.org/10.1016/j.lfs.2021.119129
Article CAS PubMed Google Scholar
Teleanu RI, Preda MD, Niculescu AG et al (2022) Current strategies to enhance delivery of drugs across the blood–brain barrier. Pharmaceutics 14:1–30. https://doi.org/10.3390/pharmaceutics14050987
Inamdar A, Gurupadayya B, Halagali P et al (2024) Unraveling neurological drug delivery: polymeric nanocarriers for enhanced blood-brain barrier penetration. Curr Drug Targets 26:243–266. https://doi.org/10.2174/0113894501339455241101065040
Ghosh A, Majie A, Karmakar V et al (2024) In-depth mechanism, challenges, and opportunities of delivering therapeutics in brain using intranasal route. AAPS PharmSciTech 25:1–23. https://doi.org/10.1208/S12249-024-02810-0
Yao P, Zhou L, Zhu L et al (2020) Mesenchymal stem cells: a potential therapeutic strategy for neurodegenerative diseases. Eur Neurol 83:235–241. https://doi.org/10.1159/000509268
Article CAS PubMed Google Scholar
Sakthiswary R, Raymond AA (2012) Stem cell therapy in neurodegenerative diseases: from principles to practice. Neural Regen Res 7:1822–1831. https://doi.org/10.3969/j.issn.1673-5374
Article PubMed PubMed Central Google Scholar
Rosenberg MB, Friedmann T, Robertson RC et al (1988) Grafting genetically modified cells to the damaged brain: restorative effects of ngf expression. Science (80-) 242:1575–1578. https://doi.org/10.1126/science.3201248
Wang Q, Matsumoto Y, Shindo T et al (2006) Neural stem cells transplantation in cortex in a mouse model of Alzheimer’s disease. J Med Investig 53:61–69. https://doi.org/10.2152/jmi.53.61
Xiong Y, Tang R, Xu J et al (2022) Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway. Stem Cell Res Ther 13:1–18. https://doi.org/10.1186/s13287-022-02969-y
Xiao J, Yang R, Biswas S et al (2015) Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. Int J Mol Sci 16:9283–9302. https://doi.org/10.3390/ijms16059283
Article CAS PubMed PubMed Central Google Scholar
Park HJ, Lee PH, Bang OY et al (2008) Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson’s disease. J Neurochem 107:141–151. https://doi.org/10.1111/j.1471-4159.2008.05589.x
Article CAS PubMed Google Scholar
Zhu Q, Zhang N, Hu N et al (2020) Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer’s disease. Mol Med Rep 21:1172–1180. https://doi.org/10.3892/mmr.2020.10918
Article CAS PubMed PubMed Central Google Scholar
Penney J, Ralvenius WT, Tsai LH (2020) Modeling Alzheimer’s disease with iPSC-derived brain cells. Mol Psychiatry 25:148–167. https://doi.org/10.1038/s41380-019-0468-3
Nakano M, Kubota K, Kobayashi E et al (2020) Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus. Sci Rep 10:1–15. https://doi.org/10.1038/s41598-020-67460-1
Ager RR, Davis JL, Agazaryan A et al (2015) Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer’s disease and neuronal loss. Hippocampus 25:813–826. https://doi.org/10.1002/hipo.22405
Article CAS PubMed PubMed Central Google Scholar
Chen X, Jiang S, Wang R et al (2023) Neural stem cells in the treatment of Alzheimer’s disease: current status, challenges, and future prospects. J Alzheimer’s Dis 94:S173–S186. https://doi.org/10.3233/JAD-220721
Sarkar S, Bhui U, Kumar B et al (2024) Correlation between cognitive impairment and peripheral biomarkers - significance of phosphorylated tau and amyloid-β in Alzheimer’s disease: a new insight. Curr Psychiatr Res Rev 21:1–25. https://doi.org/10.2174/0126660822329981241007105405
Alipour M, Nabavi SM, Arab L et al (2019) Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks. Mol Biol Rep 46:1425–1446. https://doi.org/10.1007/s11033-018-4499-7
Article CAS PubMed Google Scholar
Frozza RL, Lourenco MV, de Felice FG (2018) Challenges for Alzheimer’s disease therapy: insights from novel mechanisms beyond memory defects. Front Neurosci 12:1–13. https://doi.org/10.3389/fnins.2018.00037
Rajasekhar K, Govindaraju T (2018) Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer’s disease. RSC Adv 8:23780–23804. https://doi.org/10.1039/c8ra03620a
Article CAS PubMed PubMed Central Google Scholar
Mesulam MM (2013) Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer’s disease. J Comp Neurol 521:4124–4144. https://doi.org/10.1002/cne.23415
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