Advances in Pharmacology and Pharmacy Vol. 13(3), pp. 297 - 304
DOI: 10.13189/app.2025.130302
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Mansi Patel 1, Tanvi Dodiya 2,*, Disha Prajapati 2
1 Department of Quality Assurance, Parul Institute of Pharmacy & Research, Parul University, Vadodara, Gujarat, India
2 Department of Pharmacognosy, Parul Institute of Pharmacy & Research, Parul University, Vadodara, Gujarat, India

ABSTRACT

Forskolin, classified as a labdane-diterpenoid, exhibits the remarkable ability to stimulate vital cellular enzyme adenylyl cyclase, which triggers elevated levels of the critical secondary messenger molecule cyclic AMP across various cell types. This bioactive compound occurs naturally in the roots of Coleus forskohlii, a distinguished member of the mint family Lamiaceae. The plant is commonly known as Indian Coleus, makandi, and pashan bhedi. Various chemical and biological synthesis techniques aim to produce forskolin efficiently and sustainably. The extraction of forskolin is achieved through various techniques, including hydrotropic solubilization, ultrasonication, Soxhlet extraction, microwave-assisted solvent extraction, matrix solid-phase dispersion extraction, and heat reflux extraction using various solvents. Analytical methods for the estimation of forskolin encompass UV-visible spectroscopy, liquid chromatography (LC), high-performance liquid chromatography, thin-layer chromatography (TLC), and high-performance thin-layer chromatography. Additionally, forskolin has garnered attention in clinical and experimental studies, revealing diverse pharmacological effects. These include antiplatelet, bronchodilating, vasodilating, antihypertensive, anticancer, antidiabetic, and antiglaucoma properties. Further research on optimizing extraction methods, testing techniques, improving absorption by the body, as well as understanding the mechanisms of how forskolin acts in the body, could expand its medical uses. The versatile nature of forskolin's pharmacology underscores its potential as a valuable compound in various therapeutic applications.

KEYWORDS
Forskolin, Labdane-diterpenoid, Coleus forskohlii, Lamiaceae

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Mansi Patel , Tanvi Dodiya , Disha Prajapati , "A Review on Forskolin- A Labdane Diterpenoid," Advances in Pharmacology and Pharmacy, Vol. 13, No. 3, pp. 297 - 304, 2025. DOI: 10.13189/app.2025.130302.

(b). APA Format:
Mansi Patel , Tanvi Dodiya , Disha Prajapati (2025). A Review on Forskolin- A Labdane Diterpenoid. Advances in Pharmacology and Pharmacy, 13(3), 297 - 304. DOI: 10.13189/app.2025.130302.