Andrewartha T, Evans M, Blencowe A, Brewer K, Gordon IJ, Manning AD (2023) Landscapes of nausea: successful conditioned taste aversion in a wild red fox population. Conserv Sci Pract 5:e12984. https://doi.org/10.1111/csp2.12984
Batabyal A, Lukowiak K (2021) Configural learning memory can be transformed from intermediate term to long-term in pond snail Lymnaea stagnalis. Physiol Behav 234:113509. https://doi.org/10.1016/j.physbeh.2021.113509
Benjamin PR (2012) Distributed network organization underlying feeding behavior in the mollusk Lymnaea. Neural Syst Circ 2:4. https://doi.org/10.1186/2042-1001-2-4
Cassaigne I, Thompson R, McKenna R, Medellin RA, Given W, Remolina F, Nuñez R, Woolrich D, Luna F (2023) Successful conditioned taste aversion in jaguars. Appl Anim Behav Sci 265:105983. https://doi.org/10.1016/j.applanim.2023.105983
Davidson TL, Tracy AL, Schier LA, Swithers SE (2014) A view of obesity as a learning and memory disorder. J Exp Psychol Anim Learn Cogn 40:261–279. https://doi.org/10.1037/xan0000029
Article PubMed PubMed Central Google Scholar
Garcia J, Ervin FR, Koelling RA (1966) Learning with prolonged delay of reinforcement. Psychon Sci 5:121–122. https://doi.org/10.3758/BF03328311
Garcia J, Ervin FR, Yorke CH, Koelling RA (1967) Conditioning with delayed vitamin injections. Science 155:716–718. https://doi.org/10.1126/science.155.3763.716
Article CAS PubMed Google Scholar
Garcia J, Hankins WG, Rusiniak KW (1974) Behavioral regulation of the milieu interne in man and rat. Science 185:824–831. https://doi.org/10.1126/science.185.4154.824
Article CAS PubMed Google Scholar
Gelperin A (1975) Rapid food-aversion learning by a terrestrial mollusk. Science 189:567–570. https://doi.org/10.1126/science.1145215
Article CAS PubMed Google Scholar
Gradowski L (2024) From fringe to mainstream: the Garcia-effect. Stud Hist Philos Sci 103:114–122. https://doi.org/10.1016/j.shpsa.2023.12.004
Han JI, Janes T, Lukowiak K (2010) The role of serotonin in the enhancement of long term memory resulting from predator detection in Lymnaea. J Exp Biol 213:3603–3614. https://doi.org/10.1242/jeb.048256
Ito E, Kojima S, Lukowiak K, Sakakibara M (2013) From likes to dislikes: conditioned taste aversion in the pond snail Lymnaea stagnalis. Can J Zool 91:405–412. https://doi.org/10.1139/cjz-2012-0292
Kagan D, Hollings J, Batabyal A, Lukowiak K (2023) Five-minute exposure to a novel food substance is sufficient time for a micro-RNA-dependent long-term memory to form. J Comp Physiol A 210:83–90. https://doi.org/10.1007/s00359-023-01650-w
Karnik V, Braun M, Dalesman S, Lukowiak K (2012) Sensory input from the osphradium modulates the response to memory enhancing stressors in Lymnaea stagnalis. J Exp Biol 215:536–542. https://doi.org/10.1242/jeb.061432
Kater SB (1974) Feeding in Helisoma trivolvis: the morphological and physiological bases of a fixed action pattern. Am Zool 14:1017–1036. https://www.jstor.org/stable/3881857
Lang B, Kahnau P, Hohlbaum K, Mieske P, Andresen NP, Boon MN, Thöne-Reineke C, Lewejohann L, Diederich K (2023) Challenges and advanced concepts for the assessment of learning and memory function in mice. Front Behav Neurosci 17:1230082. https://doi.org/10.3389/fnbeh.2023.1230082
Article PubMed PubMed Central Google Scholar
Nakamura H, Ito I, Kojima S, Fujito Y, Suzuki H, Ito E (1999) Histological characterization of lip and tentacle nerves in Lymnaea stagnalis. Neurosci Res 33:127–136. https://doi.org/10.1016/s0168-0102(98)00121-7
Article CAS PubMed Google Scholar
Nakamura H, Kojima S, Kobayashi S, Ito I, Fujito Y, Suzuki H et al (1999) Physiological characterization of lip and tentacle nerves in Lymnaea stagnalis. Neurosci Res 33:291–298. https://doi.org/10.1016/S0168-0102(99)00020-6
Article CAS PubMed Google Scholar
Rivi V, Batabyal A, Juego K, Kakadiya M, Benatti C, Blom JMC, Lukowiak K (2021) To eat or not to eat: a Garcia-effect in pond snails (Lymnaea stagnalis). J Comp Physiol A 207:479–495. https://doi.org/10.1007/s00359-021-01491-5
Rivi V, Batabyal A, Benatti C, Blom J, Tascedda F, Lukowiak K (2022) Novel taste, sickness, and memory: lipopolysaccharide to induce a Garcia-like effect in inbred and outbred strains of Lymnaea stagnalis. Physiol Behav 263:114137. https://doi.org/10.1016/j.physbeh.2023.114137
Rivi V, Batabyal A, Benatti C, Sarti P, Blom J, Tascedda F, Lukowiak K (2024) A translational and multidisciplinary approach to study the Garcia-effect, a higher form of learning with deep evolutionary roots. J Exp Biol 227:jeb247325. https://doi.org/10.1242/jeb.247325
Rivi V, Batabyal A, Benatti C, Tascedda F, Blom J, Lukowiak K (2025) Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails. Water Biol Secur 4:100315. https://doi.org/10.1016/j.watbs.2024.100315
Seligman ME (1970) On the generality of the laws of learning. Psychol Rev 77:406–418. https://doi.org/10.1037/h0029790
Straub VA, Styles BJ, Ireland JS, O’Shea M, Benjamin PR (2004) Central localization of plasticity involved in appetitive conditioning in Lymnaea. Learn Mem 11:787–793. https://doi.org/10.1101/lm.77004
Article PubMed PubMed Central Google Scholar
Sugai R, Shiga H, Azami S, Watanabe T, Sadamoto H, Fujito Y, Lukowiak K (2006) Taste discrimination in conditioned taste aversion of the pond snail Lymnaea stagnalis. J Exp Biol 209:826–833. https://doi.org/10.1242/jeb.02069
Article CAS PubMed Google Scholar
Sugai R, Azami S, Shiga H, Watanabe T, Sadamoto H, Kobayashi S et al (2007) One-trial conditioned taste aversion in Lymnaea: good and poor performers in long-term memory acquisition. J Exp Biol 210:1225–1237. https://doi.org/10.1242/jeb.02735
Teskey ML, Lukowiak KS, Riaz H, Dalesman S, Lukowiak K (2012) What’s hot: the enhancing effects of thermal stress on long-term memory formation in Lymnaea stagnalis. J Exp Biol 215:4322–4329. https://doi.org/10.1242/jeb.075960
Tracy AL, Phillips RJ, Chi MM, Powley TL, Davidson TL (2004) The gastrointestinal tract “tastes” nutrients: evidence from the intestinal taste aversion paradigm. Am J Physiol Regul Integr Comp Physiol 287:R1086–R1100. https://doi.org/10.1152/ajpregu.00047.2004
Article CAS PubMed Google Scholar
Wyeth RC, Croll RP (2011) Peripheral sensory cells in the cephalic sensory organs of Lymnaea stagnalis. J Comp Neurol 519:1894–1913. https://doi.org/10.1002/cne.22607
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