Management Strategies for Chronic Suppurative Otitis Media and Why They Fail

Acuin J (2004) Chronic suppurative otitis media: burden of illness and management options. World Health Organization

Gupta A, Thai A, Santa Maria PL (2024) Epidemiology of chronic suppurative otitis media in the United States. Ann Otol Rhinol Laryngol 133:741–749. https://doi.org/10.1177/00034894241257103

Monasta L, Ronfani L, Marchetti F, Montico M, Vecchi Brumatti L, Bavcar A, Grasso D, Barbiero C, Tamburlini G (20212) Burden of disease caused by otitis media: systematic review and global estimates. PLoS One 7:e36226. https://doi.org/10.1371/journal.pone.0036226

Wiet RJ (1979) Patterns of ear disease in the Southwestern American Indian. Arch Otolaryngol - Head Neck Surg 105:381–385. https://doi.org/10.1001/archotol.1979.00790190007002

Article  CAS  Google Scholar 

Maynard JE (1972) Otitis media in Alaskan Eskimo children. JAMA 219:597. https://doi.org/10.1001/jama.1972.03190310029006

Article  CAS  PubMed  Google Scholar 

van der Veen EL, Schilder AGM, van Heerbeek N, Verhoeff M, Zielhuis GA, Rovers MM (2006) Predictors of chronic suppurative otitis media in children. Arch Otolaryngol Neck Surg 132:1115. https://doi.org/10.1001/archotol.132.10.1115

Article  Google Scholar 

Heward E, Saeed H, Bate S, Rajai A, Molloy J, Isba R, Ashcroft DM, Hay AD, Nichani JR, Bruce IA (2024) Risk factors associated with the development of chronic suppurative otitis media in children: systematic review and meta-analysis. Clin Otolaryngol 49:62–73. https://doi.org/10.1111/coa.14102

Article  PubMed  Google Scholar 

Morris P. Chronic suppurative otitis media. BMJ Clin Evid. 2012 Aug 6;2012:0507. PMID: 23870746; PMCID: PMC3412293.

Neeff M, Biswas K, Hoggard M, Taylor MW, Douglas R (2016) Molecular microbiological profile of chronic suppurative otitis media. J Clin Microbiol 54:2538–2546. https://doi.org/10.1128/JCM.01068-16

Article  PubMed  PubMed Central  Google Scholar 

Ahn JH, Kim M-N, An YS, Moon BJ (2012) Preoperative, intraoperative, and postoperative results of bacterial culture from patients with chronic suppurative otitis media. Otol Neurotol 33:54–59. https://doi.org/10.1097/MAO.0b013e31823dbc70

Article  PubMed  Google Scholar 

Albert RRA, Job A, Kuruvilla G, Joseph R, Brahmadathan KN, John A (2005) Outcome of bacterial culture from mastoid granulations: is it relevant in chronic ear disease? J Laryngol Otol 119:774–778. https://doi.org/10.1258/002221505774481219

Article  PubMed  Google Scholar 

Juyal D, Negi V, Pal S, Adekhandi S, Sharma M, Sharma N, Prakash R (2013) Microbiology of chronic suppurative otitis media in a tertiary care setup of Uttarakhand state, India. N Am J Med Sci 5:282. https://doi.org/10.4103/1947-2714.110436

Article  PubMed  PubMed Central  Google Scholar 

Attallah MS (2000) Microbiology of chronic suppurative otitis media with cholesteatoma. Saudi Med J 21:924–927

CAS  PubMed  Google Scholar 

Mittal R, Lisi CV, Gerring R, Mittal J, Mathee K, Narasimhan G, Azad RK, Yao Q, Grati M, Yan D, Eshraghi AA, Angeli SI, Telischi FF, Liu X-Z (2015) Current concepts in the pathogenesis and treatment of chronic suppurative otitis media. J Med Microbiol 64:1103–1116. https://doi.org/10.1099/jmm.0.000155

Article  PubMed  PubMed Central  Google Scholar 

Panchasara A, Singh D, Mandavia S, Jha S, Tripathi C (2015) Efficacy and safety of ofloxacin and its combination with dexamethasone in chronic suppurative otitis media. A randomised, double blind, parallel group, comparative study. Acta Otorhinolaryngol Ital 35:39–44

Kiris M, Berktas M, Egeli E, Kutluhan A (1998) The efficacy of topical ciprofloxacin in the treatment of chronic suppurative otitis media. Ear Nose Throat J 77:904–5, 909

Thai A, Aaron KA, Kaufman AC, Santa Maria PL (2021) Long-term health utilization and outcomes in chronic suppurative otitis media. Otolaryngol Head Neck Surg 167:341–349. https://doi.org/10.1177/01945998211050626

Head K, Chong L-Y, Bhutta MF, Morris PS, Vijayasekaran S, Burton MJ, Schilder AG, Brennan-Jones CG (2020) Antibiotics versus topical antiseptics for chronic suppurative otitis media. Cochrane Database Syst Rev 2020. https://doi.org/10.1002/14651858.CD013056.pub2

Jensen RG, Johansen HK, Bjarnsholt T, Eickhardt-Sørensen SR, Homøe P (2017) Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? Eur Arch Oto-Rhino-Laryngology 274:2741–2747. https://doi.org/10.1007/s00405-017-4586-8

Article  Google Scholar 

Ohyama M, Furuta S, Ueno K, Katsuda K, Nobori T, Kiyota R, Miyazaki Y (1999) Ofloxacin otic solution in patients with otitis media. Arch Otolaryngol Neck Surg 125:337. https://doi.org/10.1001/archotol.125.3.337

Article  CAS  Google Scholar 

Santa Maria PL, Kaufman AC, Bacacao B, Thai A, Chen X, Xia A, Cao Z, Fouad A, Bekale LA (2021) Topical therapy failure in chronic suppurative otitis media is due to persister cells in biofilms. Otol Neurotol 42:e1263–e1272. https://doi.org/10.1097/MAO.0000000000003222

Alhede M, Alhede M, Qvortrup K, Kragh KN, Jensen PØ, Stewart PS, Bjarnsholt T (2020) The origin of extracellular DNA in bacterial biofilm infections in vivo. Pathog Dis 78. https://doi.org/10.1093/femspd/ftaa018

Liu HY, Prentice EL, Webber MA (2024) Mechanisms of antimicrobial resistance in biofilms. NPJ Antimicrob Resist 2:27. https://doi.org/10.1038/s44259-024-00046-3

Article  PubMed  PubMed Central  Google Scholar 

Khomtchouk KM, Joseph LI, Khomtchouk BB, Kouhi A, Massa S, Xia A, Koliesnik I, Pletzer D, Bollyky PL, Santa Maria PL (2021) Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media. NPJ Biofilms Microbiomes 7:31. https://doi.org/10.1038/s41522-021-00200-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia A, Thai A, Cao Z, Chen X, Chen J, Bacacao B, Bekale LA, Schiel V, Bollyky PL, Maria PLS (2022) Chronic suppurative otitis media causes macrophage-associated sensorineural hearing loss. J Neuroinflammation 19:224. https://doi.org/10.1186/s12974-022-02585-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Z, Chen X, Chen J, Xia A, Bacacao B, Tran J, Sharma D, Bekale LA, Santa Maria PL (2022) Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance. Nanoscale 14:10016–10032. https://doi.org/10.1039/d2nr01003h

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khomtchouk KM, Kouhi A, Xia A, Bekale LA, Massa SM, Sweere JM, Pletzer D, Hancock RE, Bollyky PL, Santa Maria PL (2020) A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation. Sci Adv 6:eabc1828. https://doi.org/10.1126/sciadv.abc1828

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honeybourne D, Andrews JM, Ashby JP, Lodwick R, Wise R (1988) Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa. Thorax 43:715–719. https://doi.org/10.1136/thx.43.9.715

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honeybourne D (1994) Antibiotic penetration into lung tissues. Thorax 49:104–106. https://doi.org/10.1136/thx.49.2.104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onali MA, Bareeqa SB, Zia S, Ahmed SI, Owais A, Ahmad AN (2018) Efficacy of empirical therapy with combined ciprofloxacin versus topical drops alone in patients with tubotympanic chronic suppurative otitis media: a randomized double-blind controlled trial. Clin Med Insights Ear Nose Throat 11:1179550617751907. https://doi.org/10.1177/1179550617751907

Article  PubMed  PubMed Central  Google Scholar 

Renukananda GS, Santosh UP, George NM (2014) Topical vs combination ciprofloxacin in the management of discharging chronic suppurative otitis media. J Clin Diagn Res 8:KC01-4. https://doi.org/10.7860/JCDR/2014/8038.4421

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abi Hachem R, Goncalves S, Walker T, Angeli S (2018) Middle ear irrigation using a hydrodebrider decreases biofilm surface area in an animal model of otitis media. Laryngoscope Investig Otolaryngol 3:231–237. https://doi.org/10.1002/lio2.164

Article  PubMed  PubMed Central  Google Scholar 

Bahamondez-Canas TF, Zhang H, Tewes F, Leal J, Smyth HDC (2018) PEGylation of tobramycin improves mucus penetration and antimicrobial activity against Pseudomonas aeruginosa biofilms in vitro. Mol Pharm 15:1643–1652. https://doi.org/10.1021/acs.molpharmaceut.8b00011

Article  CAS  PubMed  Google Scholar 

Long TE, Keding LC, Lewis DD, Anstead MI, Withers TR, Yu HD (2016) Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa. Bioorg Med Chem Lett 26:1305–1309. https://doi.org/10.1016/j.bmcl.2016.01.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meers P, Neville M, Malinin V, Scotto AW, Sardaryan G, Kurumunda R, Mackinson C, James G, Fisher S, Perkins WR (2008) Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. J Antimicrob Chemother 61:859–868. https://doi.org/10.1093/jac/dkn059

Article  CAS  PubMed  Google Scholar 

Singh R, Ray P, Das A, Sharma M (2010) Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms. J Antimicrob Chemother 65:1955–1958.

Comments (0)

No login
gif