Roy T, Lloyd CE, Suppl. 8–21.

Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.

Article  PubMed  PubMed Central  Google Scholar 

Rubin RR, Ma Y, Marrero DG, Peyrot M, Barrett-Connor EL, Kahn SE, et al. Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care. 2008;31(3):420–6.

Article  PubMed  Google Scholar 

Subba R, Sandhir R, Singh SP, Mallick BN, Mondal AC. Pathophysiology linking depression and type 2 diabetes: psychotherapy, physical exercise, and fecal microbiome transplantation as damage control. Eur J Neurosci. 2021;53(8):2870–900.

Article  CAS  PubMed  Google Scholar 

Videbech P. PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatr Scand. 2000;101(1):11–20.

Article  CAS  PubMed  Google Scholar 

Wu L, Zhang X, Zhao L. Human ApoE Isoforms differentially modulate brain glucose and ketone body metabolism: implications for Alzheimer’s Disease Risk reduction and early intervention. J Neurosci. 2018;38(30):6665–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dolgin E. The most popular genes in the human genome. Nature. 2017;551(7681):427–31.

Article  CAS  PubMed  Google Scholar 

Mahley RW, Weisgraber KH, Huang Y, Apolipoprotein E. Structure determines function, from atherosclerosis to Alzheimer’s disease to AIDS. J Lipid Res. 2009;50(SupplSuppl):183–8.

Article  Google Scholar 

Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, et al. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res. 1982;23(6):911–4.

Article  CAS  PubMed  Google Scholar 

Arbones-Mainar JM, Johnson LA, Altenburg MK, Maeda N. Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice. Int J Obes (Lond). 2008;32(10):1595–605.

Article  CAS  PubMed  Google Scholar 

Martínez-Martínez AB, Torres-Perez E, Devanney N, Del Moral R, Johnson LA, Arbones-Mainar JM. Beyond the CNS: the many peripheral roles of APOE. Neurobiol Dis. 2020;138:104809.

Article  PubMed  PubMed Central  Google Scholar 

Fang W, Xiao N, Zeng G, Bi D, Dai X, Mi X, et al. Correction to: APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline. Transl Psychiatry. 2021;11(1):603.

Article  PubMed  PubMed Central  Google Scholar 

Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc Natl Acad Sci U S A. 2004;101(1):284–9.

Article  CAS  PubMed  Google Scholar 

Ramachandran G, Marder K, Tang M, Schofield PW, Chun MR, Devanand DP, et al. A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer’s disease. Neurology. 1996;47(1):256–9.

Article  CAS  PubMed  Google Scholar 

Müller-Thomsen T, Arlt S, Ganzer S, Mann U, Mass R, Naber D, et al. Depression in Alzheimer’s disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. Dement Geriatr Cogn Disord. 2002;14(2):59–63.

Article  PubMed  Google Scholar 

Murphy GM Jr, Taylor J, Tinklenberg JR, Yesavage JA. The apolipoprotein E epsilon 4 allele is associated with increased behavioral disturbance in Alzheimer’s disease. Am J Geriatr Psychiatry. 1997;5(1):88–9.

PubMed  Google Scholar 

Amiri M, Mohammadi A, Forghani A. The Center for Epidemiologic Studies Depression Scale (CES-D) validation in order to depression screening among students. Proceedings of the 4th students’ mental health seminar; Shiraz, Iran2008. p. 43 – 5.

Radloff LS, The CES-D, Scale. A self-report Depression Scale for Research in the General Population. Appl Psychol. 1977;1:385–401.

Google Scholar 

Zhan XH, Zha GC, Jiao JW, Yang LY, Zhan XF, Chen JT, et al. Rapid identification of apolipoprotein E genotypes by high-resolution melting analysis in chinese Han and African Fang populations. Exp Ther Med. 2015;9(2):469–75.

Article  CAS  PubMed  Google Scholar 

Cantillon M, Harwood D, Barker W, St George-Hyslop P, Tsuda T, Ekatarina R, et al. No association between apolipoprotein E genotype and late-onset depression in Alzheimer’s disease. Biol Psychiatry. 1997;41(2):246–8.

Article  CAS  PubMed  Google Scholar 

Liu CY, Hong CJ, Liu TY, Lin KN, Wang PN, Chi CW, et al. Lack of association between the apolipoprotein E genotype and depression in Alzheimer’s disease. J Geriatr Psychiatry Neurol. 2002;15(1):20–3.

Article  PubMed  Google Scholar 

Giltay EJ, van Reedt Dortland AK, Nissinen A, Giampaoli S, van Veen T, Zitman FG, et al. Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly european men: the FINE study. J Affect Disord. 2009;115(3):471–7.

Article  CAS  PubMed  Google Scholar 

Wang WW, Liu XL, Ruan Y, Wang L, Bao TH. Depression was associated with apolipoprotein E ε4 allele polymorphism: a meta-analysis. Iran J Basic Med Sci. 2019;22(2):112–7.

PubMed  PubMed Central  Google Scholar 

Lavie I, Beeri MS, Berman Y, Schwartz Y, Soleimani L, Heymann A, et al. Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes. Int J Geriatr Psychiatry. 2021;36(10):1567–75.

Article  PubMed  PubMed Central  Google Scholar 

Steffens DC, Norton MC, Hart AD, Skoog I, Corcoran C, Breitner JC. Apolipoprotein E genotype and major depression in a community of older adults. The Cache County study. Psychol Med. 2003;33(3):541–7.

Article  CAS  PubMed  Google Scholar 

Li W. Association of APOE E2 and low-density lipoprotein with depressive symptoms in Chinese senile schizophrenia inpatients: a cross-sectional study. Schizophr Res Cogn. 2021;23:100193.

Article  PubMed  Google Scholar 

Safieh M, Korczyn AD, Michaelson DM. ApoE4: an emerging therapeutic target for Alzheimer’s disease. BMC Med. 2019;17(1):64.

Article  PubMed  PubMed Central  Google Scholar 

Yassine HN, Finch CE. APOE alleles and Diet in Brain Aging and Alzheimer’s Disease. Front Aging Neurosci. 2020;12:150.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia AR, Finch C, Gatz M, Kraft T, Eid Rodriguez D, Cummings D et al. APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical amerindian subsistence population. Elife. 2021;10.

Persons JE, Fiedorowicz JG. Depression and serum low-density lipoprotein: a systematic review and meta-analysis. J Affect Disord. 2016;206:55–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Y, Dai X, Zhang J, Chen X. Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis. Behav Brain Res. 2022;423:113772.

Article  CAS  PubMed  Google Scholar 

Vilagut G, Forero CG, Barbaglia G, Alonso J. Screening for Depression in the General Population with the Center for epidemiologic studies Depression (CES-D): a systematic review with Meta-analysis. PLoS ONE. 2016;11(5):e0155431.

Article  PubMed  PubMed Central  Google Scholar