Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation

Eapen M, Rubinstein P, Zhang M-J, Stevens C, Kurtzberg J, Scaradavou A, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–54.

Article  PubMed  Google Scholar 

Barker JN, Byam C, Scaradavou A. How I treat: the selection and acquisition of unrelated cord blood grafts. Blood. 2011;117:2332–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawase T, Morishima Y, Matsuo K, Kashiwase K, Inoko H, Saji H, et al. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood. 2007;110:2235–41.

Article  CAS  PubMed  Google Scholar 

Morishima S, Kashiwase K, Matsuo K, Azuma F, Yabe T, Sato-Otsubo A, et al. High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation. Haematologica. 2016;101:491–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koyama M, Hill GR. Alloantigen presentation and graft-versus-host disease: fuel for the fire. Blood. 2016;127:2963–70.

Article  CAS  PubMed  Google Scholar 

Sidney J, Peters B, Frahm N, Brander C, Sette A. HLA class I supertypes: a revised and updated classification. BMC Immunol. 2008;9:1–15.

Article  PubMed  PubMed Central  Google Scholar 

Lund O, Nielsen M, Kesmir C, Petersen AG, Lundegaard C, Worning P, et al. Definition of supertypes for HLA molecules using clustering of specificity matrices. Immunogenetics. 2004;55:797–810.

Article  CAS  PubMed  Google Scholar 

Harjanto S, Ng LFP, Tong JC. Clustering HLA class I superfamilies using structural interaction patterns. PLoS One 2014; 9. e86655. https://doi.org/10.1371/journal.pone.0086655.

Sette A, Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics. 1999;50:201–12.

Article  CAS  PubMed  Google Scholar 

Tong JC, Tan TW, Ranganathan S. In silico grouping of peptide/HLA class I complexes using structural interaction characteristics. Bioinformatics. 2007;23:177–83.

Article  CAS  PubMed  Google Scholar 

Doytchinova IA, Guan P, Flower DR. Identifiying human MHC supertypes using bioinformatic methods. J Immunol. 2004;172:4314–23.

Article  CAS  PubMed  Google Scholar 

Richardson J, Reyburn HT, Luque I, Valés‐Gómez M, Strominger JL. Definition of polymorphic residues on killer Ig‐like receptor proteins which contribute to the HLA‐C binding site. Eur J Immunol. 2000;30:1480–5.

Article  CAS  PubMed  Google Scholar 

Doytchinova IA, Flower DR. In silico identification of supertypes for class II MHCs. J Immunol. 2005;174:7085–95.

Article  CAS  PubMed  Google Scholar 

Trachtenberg E, Korber B, Sollars C, Kepler TB, Hraber PT, Hayes E, et al. Advantage of rare HLA supertype in HIV disease progression. Nat Med. 2003;9:928–35.

Article  CAS  PubMed  Google Scholar 

Deutekom HWM, van, Hoof I, Bontrop RE, Kesmir C. A comparative analysis of viral peptides presented by contemporary human and chimpanzee MHC class I molecules. J Immunol. 2011;187:5995–6001.

Article  PubMed  Google Scholar 

Lazaryan A, Song W, Lobashevsky E, Tang J, Shrestha S, Zhang K, et al. Human leukocyte antigen class I supertypes and HIV-1 control in African Americans. J Virol. 2010;84:2610–7.

Article  CAS  PubMed  Google Scholar 

Matsueda S, Takedatsu H, Sasada T, Azuma K, Ishihara Y, Komohara Y, et al. New peptide vaccine candidates for epithelial cancer patients With HLA-A3 supertype alleles. J Immunother. 2007;30:274–81.

Article  CAS  PubMed  Google Scholar 

Matsueda S, Takedatsu H, Yao A, Tanaka M, Noguchi M, Itoh K, et al. Identification of peptide vaccine candidates for prostate cancer patients with HLA-A3 supertype alleles. Clin Cancer Res. 2005;11:6933–43.

Article  CAS  PubMed  Google Scholar 

Chowell D, Morris LGT, Grigg CM, Weber JK, Samstein RM, Makarov V, et al. Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science. 2018;359:582–7.

Article  CAS  PubMed  Google Scholar 

Karosiene E, Lundegaard C, Lund O, Nielsen M. NetMHCcons: a consensus method for the major histocompatibility complex class I predictions. Immunogenetics. 2012;64:177–86.

Article  CAS  PubMed  Google Scholar 

Thomsen M, Lundegaard C, Buus S, Lund O, Nielsen M. MHCcluster, a method for functional clustering of MHC molecules. Immunogenetics. 2013;65:655–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalita P, Padhi AK, Zhang KYJ, Tripathi T. Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2. Micro Pathog. 2020;145:104236.

Article  CAS  Google Scholar 

Lazaryan A, Wang T, Spellman SR, Wang H-L, Pidala J, Nishihori T, et al. Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research. Haematologica. 2016;101:1267–74.

Article  PubMed  PubMed Central  Google Scholar 

Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG, et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106:2912–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armand P, Kim HT, Logan BR, Wang Z, Alyea EP, Kalaycio ME, et al. Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation. Blood. 2014;123:3664–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giralt S, Ballen K, Rizzo D, Bacigalupo A, Horowitz M, Pasquini M, et al. Reduced-intensity conditioning regimen workshop: defining the dose spectrum. report of a workshop convened by the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Traspl. 2009;15:367–9.

Article  Google Scholar 

Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transpl. 2009;15:1628–33.

Article  Google Scholar 

Gaballa A, Clave E, Uhlin M, Toubert A, Arruda LCM. Evaluating thymic function after human hematopoietic stem cell transplantation in the personalized medicine era. Front Immunol. 2020;11:1341.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clave E, Lisini D, Douay C, Giorgiani G, Busson M, Zecca M, et al. Thymic function recovery after unrelated donor cord blood or T-cell depleted HLA-haploidentical stem cell transplantation correlates with leukemia relapse. Front Immunol. 2013;4:54.

Article  PubMed  PubMed Central  Google Scholar 

Song ES, Linsk R, Olson CA, McMillan M, Goodenow RS. Allospecific cytotoxic T lymphocytes recognize an H-2 peptide in the context of a murine major histocompatibility complex class I molecule. Proc Natl Acad Sci. 1988;85:1927–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kievits F, Ivanyi P. A subpopulation of mouse cytotoxic T lymphocytes recognizes allogeneic H-2 class I antigens in the context of other H-2 class I molecules. J Exp Med. 1991;174:15–19.

Article  CAS  PubMed  Google Scholar 

Krenger W, Holländer GA. The immunopathology of thymic GVHD. Semin Immunopathol. 2008;30:439.

Article  PubMed  Google Scholar 

Godthelp BC, van Tol MJ, Vossen JM, van Den Elsen PJ. T-cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplantation with T-cell–depleted or unmanipulated grafts: evaluation of overall and antigen-specific T-cell repertoires. Blood. 1999;94:4358–69.

Article  CAS  PubMed  Google Scholar 

Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T, et al. Distinct contributions of CD4+ and CD8+naive and memory T-cell subsets to overall T-cell–receptor repertoire complexity following transplantation of T-cell–depleted CD34-selected hematopoietic progenitor cells from unrelated donors. Blood. 2002;100:1915–8.

Article  CAS  PubMed  Google Scholar 

Roux E, Dumont-Girard F, Starobinski M, Siegrist CA, Helg C, Chapuis B, et al. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood. 2000;96:2299–303.

Article  CAS  PubMed  Google Scholar 

Touma W, Brunstein CG, Cao Q, Miller JS, Curtsinger J, Verneris MR, et al. Dendritic cell recovery impacts outcomes after umbilical cord blood and sibling donor transplantation for hematologic malignancies. Biol Blood Marrow Transpl. 2017;23:1925–31.

Article  Google Scholar 

Reddy P, Maeda Y, Liu C, Krijanovski OI, Korngold R, Ferrara JLM. A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. Nat Med. 2005;11:1244–9.

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