In vitro and in vivo activity of ceftazidime/avibactam and aztreonam alone or in combination against mcr-9, serine- and metallo-β-lactamases–co-producing carbapenem-resistant Enterobacter cloacae complex

Perez F, Bonomo RA (2019) Carbapenem-resistant Enterobacteriaceae: global action required. Lancet Infect Dis 19(6):561–562. https://doi.org/10.1016/S1473-3099(19)30210-5

Article  PubMed  Google Scholar 

Davin-Regli A, Lavigne J-P, Pagès J-M (2019) Enterobacter spp.: update on taxonomy, clinical aspects, and emerging Antimicrobial Resistance. Clin Microbiol Rev 32(4). https://doi.org/10.1128/CMR.00002-19

Chen J, Tian S, Nian H, Wang R, Li F, Jiang N, Chu Y (2021) Carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital in Northeast China, 2010–2019. BMC Infect Dis 21(1):611. https://doi.org/10.1186/s12879-021-06250-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin C, Zhang J, Wang Q, Chen H, Wang X, Zhang Y, Wang H (2018) Molecular characterization of Carbapenem-Resistant Enterobacter cloacae in 11 Chinese cities. Front Microbiol 9:1597. https://doi.org/10.3389/fmicb.2018.01597

Article  PubMed  PubMed Central  Google Scholar 

Gruber TM, Göttig S, Mark L, Christ S, Kempf VAJ, Wichelhaus TA, Hamprecht A (2015) Pathogenicity of pan-drug-resistant Serratia marcescens harbouring blaNDM-1. J Antimicrob Chemother 70(4):1026–1030. https://doi.org/10.1093/jac/dku482

Article  CAS  PubMed  Google Scholar 

Biedenbach D, Bouchillon S, Hackel M, Hoban D, Kazmierczak K, Hawser S, Badal R (2015) Dissemination of NDM metallo-β-lactamase genes among clinical isolates of Enterobacteriaceae collected during the SMART global surveillance study from 2008 to 2012. Antimicrob Agents Chemother 59(2):826–830. https://doi.org/10.1128/AAC.03938-14

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaye KS, Pogue JM, Tran TB, Nation RL, Li J (2016) Agents of last Resort: Polymyxin Resistance. Infect Dis Clin North Am 30(2):391–414. https://doi.org/10.1016/j.idc.2016.02.005

Article  PubMed  Google Scholar 

Liu Y-Y, Wang Y, Walsh TR, Yi L-X, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu L-F, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu J-H, Shen J (2016) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16(2):161–168. https://doi.org/10.1016/S1473-3099(15)00424-7

Article  CAS  PubMed  Google Scholar 

Hussein NH, Al-Kadmy IMS, Taha BM, Hussein JD (2021) Mobilized colistin resistance (mcr) genes from 1 to 10: a comprehensive review. Mol Biol Rep 48(3):2897–2907. https://doi.org/10.1007/s11033-021-06307-y

Article  CAS  PubMed  Google Scholar 

Ling Z, Yin W, Shen Z, Wang Y, Shen J, Walsh TR (2020) Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9. J Antimicrob Chemother 75(11):3087–3095. https://doi.org/10.1093/jac/dkaa205

Article  CAS  PubMed  Google Scholar 

Li Y, Dai X, Zeng J, Gao Y, Zhang Z, Zhang L (2020) Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9. Sci Rep 10(1):8113. https://doi.org/10.1038/s41598-020-65106-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Hang X, Xiao X, Chu W, Li X, Liu Y, Li X, Zhou Q, Li J (2021) Co-occurrence of bla NDM-1 and mcr-9 in a conjugative IncHI2/HI2A plasmid from a bloodstream infection-causing carbapenem-resistant Klebsiella pneumoniae. Front Microbiol 12:756201. https://doi.org/10.3389/fmicb.2021.756201

Article  PubMed  PubMed Central  Google Scholar 

Simoni S, Mingoia M, Brenciani A, Carelli M, Lleò MM, Malerba G, Vignaroli C (2021) First IncHI2 plasmid carrying mcr-9.1, blaVIM-1, and double copies of blaKPC-3 in a Multidrug-Resistant Escherichia coli Human isolate. mSphere 6(3):e0030221. https://doi.org/10.1128/mSphere.00302-21

Article  PubMed  Google Scholar 

Zhou H, Wang S, Wu Y, Dong N, Ju X, Cai C, Li R, Li Y, Liu C, Lu J, Chan EW-C, Chen S, Zhang R, Shen Z (2022) Carriage of the mcr-9 and mcr-10 genes in clinical strains of the Enterobacter cloacae complex in China: a prevalence and molecular epidemiology study. Int J Antimicrob Agents 60(4):106645. https://doi.org/10.1016/j.ijantimicag.2022.106645

Article  CAS  PubMed  Google Scholar 

Jiang S, Wang X, Yu H, Zhang J, Wang J, Li J, Li X, Hu K, Gong X, Gou X, Yang Y, Li C, Zhang X (2022) Molecular antibiotic resistance mechanisms and co-transmission of the mcr-9 and metallo-β-lactamase genes in carbapenem-resistant Enterobacter cloacae complex. Front Microbiol 13:1032833. https://doi.org/10.3389/fmicb.2022.1032833

Article  PubMed  PubMed Central  Google Scholar 

Lu G, Tang H, Xia Z, Yang W, Xu H, Liu Z, Ni S, Wang Z, Shen J (2022) In vitro and in vivo antimicrobial activities of Ceftazidime/Avibactam alone or in combination with Aztreonam against Carbapenem-Resistant Enterobacterales. Infect Drug Resist 15:7107–7116. https://doi.org/10.2147/IDR.S385240

Article  PubMed  PubMed Central  Google Scholar 

Gong X, Zhang J, Su S, Fu Y, Bao M, Wang Y, Zhang X (2018) Molecular characterization and epidemiology of carbapenem non-susceptible Enterobacteriaceae isolated from the eastern region of Heilongjiang Province, China. BMC Infect Dis 18(1):417. https://doi.org/10.1186/s12879-018-3294-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Montero MM, Domene Ochoa S, López-Causapé C, Luque S, Sorlí L, Campillo N, López Montesinos I, Padilla E, Prim N, Angulo-Brunet A, Grau S, Oliver A, Horcajada JP (2021) Time-kill evaluation of antibiotic combinations containing ceftazidime-avibactam against extensively drug-resistant Pseudomonas aeruginosa and their potential role against Ceftazidime-Avibactam-Resistant isolates. Microbiol Spectr 9(1):e0058521. https://doi.org/10.1128/spectrum.00585-21

Article  CAS  PubMed  Google Scholar 

Kuai J, Zhang Y, Lu B, Chen H, Zhang Y, Li H, Wang Y, Wang Q, Wang H, Wang X (2023) In vitro synergistic activity of Ceftazidime-Avibactam in Combination with Aztreonam or Meropenem Against Clinical enterobacterales Producing blaKPC or blaNDM. Infect Drug Resist 16:3171–3182. https://doi.org/10.2147/IDR.S408228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang H, Chen G, Hu L, Liu Y, Cheng J, Ye Y, Li J (2018) Enhanced efficacy of imipenem-colistin combination therapy against multiple-drug-resistant Enterobacter cloacae: in vitro activity and a Galleria mellonella model. J Microbiol Immunol Infect 51(1):70–75. https://doi.org/10.1016/j.jmii.2016.01.003

Article  CAS  PubMed  Google Scholar 

Li X, Chen Z, Jiao J, Wang S, Wang Y, Wu W, Yang H, Lou H (2023) In vitro and in vivo activity of meropenem + avibactam against MBL-producing carbapenem-resistant Klebsiella pneumoniae. Expert Rev Anti Infect Ther 21(1):91–98. https://doi.org/10.1080/14787210.2022.2153117

Article  CAS  PubMed  Google Scholar 

Idowu T, Ammeter D, Arthur G, Zhanel GG, Schweizer F (2019) Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against MDR and XDR Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates. J Antimicrob Chemother 74(9):2640–2648. https://doi.org/10.1093/jac/dkz228

Article  CAS  PubMed  Google Scholar 

Borjan J, Meyer KA, Shields RK, Wenzler E (2020) Activity of ceftazidime-avibactam alone and in combination with polymyxin B against carbapenem-resistant Klebsiella pneumoniae in a tandem in vitro time-kill/in vivo Galleria mellonella survival model analysis. Int J Antimicrob Agents 55(1):105852. https://doi.org/10.1016/j.ijantimicag.2019.11.009

Article  CAS  PubMed  Google Scholar 

Manning N, Balabanian G, Rose M, Landman D, Quale J (2018) Activity of Ceftazidime-Avibactam against clinical isolates of Klebsiella pneumoniae, including KPC-Carrying isolates, endemic to New York City. Microb Drug Resist 24(1):35–39. https://doi.org/10.1089/mdr.2016.0293

Article  CAS  PubMed  Google Scholar 

Nath S, Moussavi F, Abraham D, Landman D, Quale J (2018) In vitro and in vivo activity of single and dual antimicrobial agents against KPC-producing Klebsiella pneumoniae. J Antimicrob Chemother 73(2):431–436. https://doi.org/10.1093/jac/dkx419

Article  CAS  PubMed  Google Scholar 

Shields RK, Nguyen MH, Hao B, Kline EG, Clancy CJ (2018) Colistin does not potentiate ceftazidime-avibactam killing of Carbapenem-Resistant Enterobacteriaceae in Vitro or suppress emergence of Ceftazidime-Avibactam Resistance. Antimicrob Agents Chemother 62(8). https://doi.org/10.1128/AAC.01018-18

Falcone M, Tiseo G, Antonelli A, Giordano C, Di Pilato V, Bertolucci P, Parisio EM, Leonildi A, Aiezza N, Baccani I, Tagliaferri E, Righi L, Forni S, Sani S, Mechi MT, Pieralli F, Barnini S, Rossolini GM, Menichetti F (2020) Clinical features and outcomes of Bloodstream infections caused by New Delhi Metallo-β-Lactamase-producing enterobacterales during a Regional Outbreak. Open Forum Infect Dis 7(2):ofaa011. https://doi.org/10.1093/ofid/ofaa011

Article  PubMed  PubMed Central  Google Scholar 

Biedenbach DJ, Kazmierczak K, Bouchillon SK, Sahm DF, Bradford PA (2015) In vitro activity of aztreonam-avibactam against a global collection of Gram-negative pathogens from 2012 and 2013. Antimicrob Agents Chemother 59(7):4239–4248. https://doi.org/10.1128/AAC.00206-15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karlowsky JA, Kazmierczak KM, de Jonge BLM, Hackel MA, Sahm DF, Bradford PA (2017) In Vitro Activity of Aztreonam-Avibactam against Enterobacteriaceae and Pseudomonas aeruginosa isolated by Clinical Laboratories in 40 countries from 2012 to 2015. Antimicrob Agents Chemother 61(9). https://doi.org/10.1128/AAC.00472-17

Sader HS, Mendes RE, Pfaller MA, Shortridge D, Flamm RK, Castanheira M (2018) Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates. Antimicrob Agents Chemother 62 (1) https://doi.org/10.1128/AAC.01856-17

Bhatnagar A, Ransom EM, Machado M-J, Boyd S, Reese N, Anderson K, Lonsway D, Elkins CA, Rasheed JK, Patel JB, Karlsson M, Brown AC, Lutgring JD (2021) Assessing the in vitro impact of ceftazidime on aztreonam/avibactam susceptibility testing for highly resistant MBL-producing enterobacterales. J Antimicrob Chemother 76(4):979–983. https://doi.org/10.1093/jac/dkaa531

Article  CAS  PubMed  Google Scholar 

Shields RK, Nguyen MH, Chen L, Press EG, Potoski BA, Marini RV, Doi Y, Kreiswirth BN, Clancy CJ (2017) Ceftazidime-Avibactam is Superior to Other Treatment regimens against Carbapenem-resistant Klebsiella pneumoniae Bacteremia. Antimicrob Agents Chemother 61(8). https://doi.org/10.1128/AAC.00883-17

van Duin D, Lok JJ, Earley M, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC, Watkins RR, Doi Y, Kaye KS, Fowler VG, Paterson DL, Bonomo RA, Evans S (2018) Colistin Versus Ceftazidime-Avibactam in the treatment of infections due to Carbapenem-Resistant Enterobacteriaceae. Clin Infect Dis 66(2):163–171. https://doi.org/10.1093/cid/cix783

Article  PubMed 

Comments (0)

No login
gif