Miranda-Filho A, Piñeros M, Ferlay J, Soerjomataram I, Monnereau A, Bray F. Epidemiological patterns of leukaemia in 184 countries: a population-based study. Lancet Haematol. 2018;5(1):e14–24.
Mueller KT, Waldron E, Grupp SA, Levine JE, Laetsch TW, Pulsipher MA, et al. Clinical pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia. Clin cancer Research: Official J Am Association Cancer Res. 2018;24(24):6175–84.
O’Connor D, Bate J, Wade R, Clack R, Dhir S, Hough R, et al. Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003. Blood. 2014;124(7):1056–61.
Vrooman LM, Silverman LB. Treatment of Childhood Acute Lymphoblastic Leukemia: prognostic factors and clinical advances. Curr Hematol Malig Rep. 2016;11(5):385–94.
Lynch SV, Pedersen O. The human intestinal microbiome in Health and Disease. N Engl J Med. 2016;375(24):2369–79.
Article CAS PubMed Google Scholar
Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. 2019;76(3):473–93.
Article CAS PubMed Google Scholar
Malard F, Mohty M. Acute lymphoblastic leukaemia. Lancet (London England). 2020;395(10230):1146–62.
Article CAS PubMed Google Scholar
Peppas I, Ford AM, Furness CL, Greaves MF. Gut microbiome immaturity and childhood acute lymphoblastic leukaemia. Nat Rev Cancer. 2023;23(8):565–76.
Article CAS PubMed Google Scholar
De Pietri S, Ingham AC, Frandsen TL, Rathe M, Krych L, Castro-Mejía JL, et al. Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: the impact of the gut microbiota. Int J Cancer. 2020;147(7):1953–62.
Qiu K, Liao X, Li Y, Huang K, Xu H, Fang J et al. Real-world presentation and prognostic effect of allogeneic blood transfusion during the intensive induction phase in Pediatric Acute Lymphoblastic Leukemia. Cancers. 2023;15(18).
Chua LL, Rajasuriar R, Lim YAL, Woo YL, Loke P, Ariffin H. Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy. BMC Cancer. 2020;20(1):151.
Article CAS PubMed PubMed Central Google Scholar
Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinf (Oxford England). 2014;30(15):2114–20.
Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9(4):357–9.
Article CAS PubMed PubMed Central Google Scholar
Beghini F, McIver LJ, Blanco-Míguez A, Dubois L, Asnicar F, Maharjan S et al. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. eLife. 2021;10.
Caspi R, Billington R, Fulcher CA, Keseler IM, Kothari A, Krummenacker M, et al. The MetaCyc database of metabolic pathways and enzymes. Nucleic Acids Res. 2018;46(D1):D633–9.
Article CAS PubMed Google Scholar
Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12(6):R60.
Article PubMed PubMed Central Google Scholar
Sági V, Makra N, Csoszánszki N, Decmann A, Szabó D, Garami M. The influence of the gut Microbiome in Paediatric Cancer Origin and Treatment. Antibiot (Basel Switzerland). 2022;11(11).
Zhou Y, Zhou C, Zhang A. Gut microbiota in acute leukemia: current evidence and future directions. Front Microbiol. 2022;13:1045497.
Article PubMed PubMed Central Google Scholar
Montassier E, Gastinne T, Vangay P, Al-Ghalith GA, Bruley des Varannes S, Massart S, et al. Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther. 2015;42(5):515–28.
Article CAS PubMed Google Scholar
Huang Y, Yang W, Liu H, Duan J, Zhang Y, Liu M, et al. Effect of high-dose methotrexate chemotherapy on intestinal bifidobacteria, Lactobacillus and Escherichia coli in children with acute lymphoblastic leukemia. Experimental Biology Med (Maywood NJ). 2012;237(3):305–11.
Thomas R, Wong WSW, Saadon R, Vilboux T, Deeken J, Niederhuber J, et al. Gut microbial composition difference between pediatric ALL survivors and siblings. Pediatr Hematol Oncol. 2020;37(6):475–88.
Article CAS PubMed PubMed Central Google Scholar
Bhuta R, DeNardo B, Wang J, Atoyan J, Zhang Y, Nelson D, et al. Durable changes in the gut microbiome in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2021;68(12):e29308.
Article CAS PubMed Google Scholar
Chua LL, Rajasuriar R, Azanan MS, Abdullah NK, Tang MS, Lee SC, et al. Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome. 2017;5(1):35.
Article PubMed PubMed Central Google Scholar
Tandon D, Haque MM, Gote M, Jain M, Bhaduri A, Dubey AK, et al. A prospective randomized, double-blind, placebo-controlled, dose-response relationship study to investigate efficacy of fructo-oligosaccharides (FOS) on human gut microflora. Sci Rep. 2019;9(1):5473.
Article PubMed PubMed Central Google Scholar
Gao X, Miao R, Zhu Y, Lin C, Yang X, Jia R, et al. A new insight into acute lymphoblastic leukemia in children: influences of changed intestinal microfloras. BMC Pediatr. 2020;20(1):290.
Article CAS PubMed PubMed Central Google Scholar
Nyhlén A, Ljungberg B, Nilsson-Ehle I, Nord CE. Impact of combinations of antineoplastic drugs on intestinal microflora in 9 patients with leukaemia. Scand J Infect Dis. 2002;34(1):17–21.
Rajagopala SV, Yooseph S, Harkins DM, Moncera KJ, Zabokrtsky KB, Torralba MG, et al. Gastrointestinal microbial populations can distinguish pediatric and adolescent Acute Lymphoblastic Leukemia (ALL) at the time of disease diagnosis. BMC Genomics. 2016;17(1):635.
Article PubMed PubMed Central Google Scholar
Hakim H, Dallas R, Wolf J, Tang L, Schultz-Cherry S, Darling V, et al. Gut Microbiome Composition predicts infection risk during Chemotherapy in Children with Acute Lymphoblastic Leukemia. Clin Infect Diseases: Official Publication Infect Dis Soc Am. 2018;67(4):541–8.
Shen Z, Gu X, Cao H, Mao W, Yang L, He M, et al. Characterization of microbiota in acute leukemia patients following successful remission induction chemotherapy without antimicrobial prophylaxis. Int Microbiology: Official J Span Soc Microbiol. 2021;24(2):263–73.
Nearing JT, Connors J, Whitehouse S, Van Limbergen J, Macdonald T, Kulkarni K, et al. Infectious complications are Associated with alterations in the gut Microbiome in Pediatric patients with Acute Lymphoblastic Leukemia. Front Cell Infect Microbiol. 2019;9:28.
Article CAS PubMed PubMed Central Google Scholar
Inaba H, Mullighan CG. Pediatric acute lymphoblastic leukemia. Haematologica. 2020;105(11):2524–39.
Article CAS PubMed PubMed Central Google Scholar
Shin NR, Whon TW, Bae JW. Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends Biotechnol. 2015;33(9):496–503.
Article CAS PubMed Google Scholar
Litvak Y, Byndloss MX, Tsolis RM, Bäumler AJ. Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction. Curr Opin Microbiol. 2017;39:1–6.
Comments (0)