Effects of the S1P/S1PR1 Signaling Pathway on High Glucose-Induced NRK-52E Epithelial-Mesenchymal Transition Via Regulation of ROS/NLRP3

Umanath, K., and J. B. Lewis. 2018. Update on Diabetic Nephropathy: Core Curriculum 2018. American Journal of Kidney Diseases 71:884–895.

Article  PubMed  Google Scholar 

Chen, C., Y. Zhao, and D. W. Wang. 2017. MiR-30C protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. Journal of the American College of Cardiology 69:2037.

Article  Google Scholar 

Kang, M. K., S. I. Kim, S. Y. Oh, W. Na, and Y. H. Kang. 2020. Tangeretin Ameliorates Glucose-Induced Podocyte Injury through Blocking Epithelial to Mesenchymal Transition Caused by Oxidative Stress and Hypoxia. International Journal of Molecular Sciences 21:1–17.

Article  Google Scholar 

Dhaval, Dixit, Okuniewska Martyna, and Schwab Susan. 2019. Secrets and lyase: Control of sphingosine 1-phosphate distribution. Immunological Reviews 289:173.

Article  Google Scholar 

Cartier, A., and T. Hla. 2019. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science 366:eaar5551-.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Proia, R. L., and T. Hla. 2015. Emerging biology of sphingosine-1-phosphate: Its role in pathogenesis and therapy. Journal of Clinical Investigation 125:1379.

Article  PubMed  PubMed Central  Google Scholar 

Donati, C., F. Cencetti, C. Bernacchioni, V. Vannuzzi, and P. Bruni. 2021. Role of sphingosine 1-phosphate signalling in tissue fibrosis. Cellular Signalling 78:109861.

Article  CAS  PubMed  Google Scholar 

Yang, Z., F. Xiong, Y. Wang, W. Gong, J. Huang, C. Chen, et al. 2016. TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. Pharmacological Research 11:226–236.

Article  Google Scholar 

Lin, Q., C. Long, Z. Wang, R. Wang, W. Shi, J. Qiu, et al. 2021. Hirudin, a thrombin inhibitor, attenuates TGF-β-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P/S1PR2/S1PR3 signaling. Experimental and Therapeutic Medicine 23:1.

Article  CAS  Google Scholar 

Awad, A. S., H. Ye, L. Huang, L. Li, and M. D. Okusa. 2006. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology 290:1516–1524.

Google Scholar 

Lien, Y. H. H., K. C. Yong, C. Cho, S. Igarashi, and L. W. Lai. 2006. S1P1-selective agonist, SEW2871, ameliorates ischemic acute renal failure - ScienceDirect. Kidney International 69:1601–1608.

Article  CAS  PubMed  Google Scholar 

Maceyka, M., S. G. Payne, S. Milstien, and S. Spiegel. 2002. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochimica et Biophysica Acta 1585:193–201.

Article  CAS  PubMed  Google Scholar 

Cuvillier, O., G. Pirianov, B. Kleuser, P. G. Vanek, and S. Spiegel. 1996. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800–803.

Article  CAS  PubMed  Google Scholar 

Cohen, J. A., F. Barkhof, G. Comi, H. P. Hartung, and L. Kappos. 2010. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. New England Journal of Medicine 362:402–415.

Article  CAS  PubMed  Google Scholar 

Kappos, L., E. W. Radue, P. O’Connor, C. Polman, R. Hohlfeld, P. Calabresi, et al. 2010. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. New England Journal of Medicine 362:387–401.

Article  CAS  PubMed  Google Scholar 

Kihara, Y., H. Mizuno, and J. Chun. 2015. Lysophospholipid receptors in drug discovery. Experimental Cell Research 333:171–177.

Article  CAS  PubMed  Google Scholar 

Santos-Gallego, C. G., T. P. Vahl, G. Goliasch, B. Picatoste, T. Arias, K. Ishikawa, et al. 2016. Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia/ReperfusionCLINICAL PERSPECTIVE. Circulation 133:954–966.

Article  CAS  PubMed  Google Scholar 

Hung, J. H., Y. S. Lu, Y. C. Wang, Y. H. Ma, and C. S. Chen. 2008. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Research 68:1204–1212.

Article  CAS  PubMed  Google Scholar 

Blaho, V. A., and T. Hla. 2014. An update on the biology of sphingosine 1-phosphate receptors. JLR Papers In Press 55:1596.

CAS  Google Scholar 

Meng, H., and V. M. Lee. 2009. Differential expression of sphingosine-1-phosphate receptors 1–5 in the developing nervous system. Ltd: John Wiley & Sons.

Book  Google Scholar 

Shirong, Z., D. W. Powell, Z. Feng, K. Phillip, and G. Luigi. 2016. Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis. Journal of Diabetes Research 2016:1–2.

Google Scholar 

Duran-Salgado M, Rubio-Guerra A. Diabetic nephropathy and inflammation. World Journal of Diabetes 2014;5:393.

Kelley, N., D. Jeltema, Y. Duan, and Y. He. 2019. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International Journal of Molecular Sciences 20:3328.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Samra, Y. A., H. S. Said, N. M. Elsherbiny, G. I. Liou, M. M. El-Shishtawy, and L. A. Eissa. 2016. Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: Role of NF-κB and NLRP3 inflammasome. Life Sciences 157:187–199.

Article  CAS  PubMed  Google Scholar 

Zhou, R., A. Tardivel, B. Thorens, I. Choi, and J. Tschopp. 2010. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nature Immunology 11:136–140.

Article  CAS  PubMed  Google Scholar 

Hou, L., L. Yang, N. Chang, X. Zhao, and L. Li. 2020. Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome. Frontiers in Immunology 11:1149.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flyvbjerg, A., F. Dagnæs-Hansen, A. S. De Vriese, B. F. Schrijvers, R. G. Tilton, and R. Rasch. 2002. Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 51 (10): 3090–3094.

Article  CAS  PubMed  Google Scholar 

Wu, M., Z. Yang, C. Zhang, Y. Shi, W. Han, S. Song, L. Mu, C. Du, and Y. Shi. 2021. Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy. Metabolism 118:154748.

Article  CAS  PubMed  Google Scholar 

Cao, Y., Z. Yang, Y. Chen, S. Jiang, Z. Wu, B. Ding, et al. 2021. An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy. Frontiers in cell and developmental biology 9:630401.

Article  PubMed  PubMed Central  Google Scholar 

Han, J., X. Pang, X. Shi, Y. Zhang, Z. Peng, and Y. Xing. 2021. Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress. Hindawi Limited 2021:1.

CAS  Google Scholar 

Balakumar, Pitchai, Ramanathan Sambathkumar, Nanjaian Mahadevan, et al. 2019. A potential role of the renin-angiotensin-aldosterone system in epithelial-to-mesenchymal transition-induced renal abnormalities: Mechanisms and therapeutic implications. Pharmacol Res 146:104314.

Article  CAS  PubMed  Google Scholar 

Imeri, F., B. S. Tanturovska, S. Schwalm, S. Saha, J. Zeng-Brouwers, H. Pavenstdt, et al. 2021. Loss of sphingosine kinase 2 enhances Wilm’s tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. Matrix Biology 98:32–48.

Article  CAS  PubMed  Google Scholar 

Drexler, Y., J. Molina, A. Mitrofanova, A. Fornoni, and S. Merscher. 2021. Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases. Journal of the American Society of Nephrology : JASN 32:9–31.

Article  CAS  PubMed  Google Scholar 

Weina, W., W. Aimei, L. Guochang, M. Fengqiao, W. Xiaoming, and B. Yongyi. 2018. S1P1 receptor inhibits kidney epithelial mesenchymal transition triggered by ischemia/reperfusion injury via the PI3K/Akt pathway. Acta Biochimica Et Biophysica Sinica 50:651.

Article 

Comments (0)

No login
gif