Kopp W. How western diet and lifestyle drive the pandemic of obesity and civilization diseases. DMSO. 2019;12:2221–36.

Article  CAS  Google Scholar 

Lynden J, Hollands T, Ogden J. Animal obesity: What insights can a one health approach offer when it comes to veterinarians ‘making every contact count’? Vet Rec. 2022;191: e1904.

Article  PubMed  Google Scholar 

Christ A, Lauterbach M, Latz E. Western diet and the immune system: an inflammatory connection. Immunity. 2019;51(5):794–811.

Article  CAS  PubMed  Google Scholar 

Tan BL, Norhaizan ME. Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function. Nutrients. 2019;11(11):2579.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González A, Esquivel-Chirino C, Durante-Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12(5):3117–32.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z, Wen H, Peng B, Weng J, Zeng F. HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. Mol Ther Nucleic Acids. 2021;24:711–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao H-T, Lee P-F, Lii C-K, Liu Y-T, Chen S-H. Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice. Food Funct. 2018;9(9):4876–87.

Article  CAS  PubMed  Google Scholar 

Hoenig MR, Sellke FW. Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy. Atherosclerosis. 2010;211(1):260–5.

Article  CAS  PubMed  Google Scholar 

Sharma S. High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain. Physiol Behav. 2021;240: 113528.

Article  CAS  PubMed  Google Scholar 

Di Rosa MC, Zimbone S, Saab MW, Tomasello MF. The pleiotropic potential of BDNF beyond neurons: implication for a healthy mind in a healthy body. Life. 2021;11(11):1256.

Article  PubMed  PubMed Central  Google Scholar 

Hoseindoost M, Alipour MR, Farajdokht F, Diba R, Bayandor P, Mehri K, et al. Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats. Avicenna J Phytomed. 2019;9(6):597–605.

CAS  PubMed  PubMed Central  Google Scholar 

Bazzari AH, Bazzari FH. BDNF therapeutic mechanisms in neuropsychiatric disorders. Int J Mol Sci. 2022;23(15):8417.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Deurwaerdère P, Chagraoui A, Di Giovanni G. Serotonin/dopamine interaction: electrophysiological and neurochemical evidence. Prog Brain Res. 2021;261:161–264.

Article  PubMed  Google Scholar 

Kim M, Bae S, Lim K-M. Impact of high fat diet-induced obesity on the plasma levels of monoamine neurotransmitters in C57BL/6 mice. Biomol Ther. 2013;21(6):476–80.

Article  Google Scholar 

Carlin J, Hill-Smith TE, Lucki I, Reyes TM. Reversal of dopamine system dysfunction in response to high-fat diet. Obesity. 2013;21(12):2513–21.

Article  CAS  PubMed  Google Scholar 

Sahin E, Orhan C, Balci TA, Erten F, Sahin K. Magnesium picolinate improves bone formation by regulation of RANK/RANKL/OPG and BMP-2/Runx2 signaling pathways in high-fat fed rats. Nutrients. 2021;13(10):3353.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miczke A, Suliburska J, Pupek-Musialik D, Ostrowska L, Jabłecka A, Krejpcio Z, et al. Effect of L-arginine supplementation on insulin resistance and serum adiponectin concentration in rats with fat diet. Int J Clin Exp Med. 2015;8(7):10358–66.

CAS  PubMed  PubMed Central  Google Scholar 

Aguilera-Mendez A, Hernández-Equihua MG, Rueda-Rocha AC, Guajardo-López C, Nieto-Aguilar R, Serrato-Ochoa D, et al. Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats. Nutr Res. 2018;57:86–96.

Article  CAS  PubMed  Google Scholar 

Sghaier R, Zarrouk A, Nury T, Badreddine I, O’Brien N, Mackrill JJ, Vejux A, Samadi M, Nasser B, Caccia C, Leoni V, Moreau T, Cherkaoui-Malki M, Salhedine Masmoudi A, Lizard G. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radic Res. 2019;53(5):535–61.

Article  CAS  PubMed  Google Scholar 

Aguilera-Méndez A, Fernández-Mejía C. The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation. BioFactors. 2012;38(5):387–94.

Article  PubMed  Google Scholar 

Turgut M, Cinar V, Pala R, Tuzcu M, Orhan C, Telceken H, et al. Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats. J Int Soc Sports Nutr. 2018;15(1):45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCarty MF, DiNicolantonio JJ. Neuroprotective potential of high-dose biotin. Med Hypotheses. 2017;109:145–9.

Article  CAS  PubMed  Google Scholar 

Ojalvo SP, Sylla S, Komorowski J, Orhan C, Tuzcu M, Sahin N, et al. The safety and absorption of magnesium biotinate in rats (P06-029-19). Curr Dev Nutr. 2019;3:nzz031-P06-029-19.

Article  PubMed Central  Google Scholar 

Sahin K, Orhan C, Kucuk O, Erten F, Tuzcu M, Sahin N, et al. Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats. Magnes Res. 2021;34(1):9–19.

Article  CAS  PubMed  Google Scholar 

Sahin K, Orhan C, Karatoprak S, Tuzcu M, Deeh PBD, Ozercan IH, et al. Therapeutic effects of a novel form of biotin on propionic acid-induced autistic features in rats. Nutrients. 2022;14(6):1280.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L. l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. Food Chem Toxicol. 2018;115:315–28.

Article  CAS  PubMed  Google Scholar 

Javrushyan H, Nadiryan E, Grigoryan A, Avtandilyan N, Maloyan A. Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats. Exp Mol Pathol. 2022;126: 104763.

Article  CAS  PubMed  Google Scholar 

Jobgen W, Fu WJ, Gao H, Li P, Meininger CJ, Smith SB, et al. High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Amino Acids. 2009;37(1):187–98.

Article  CAS  PubMed  Google Scholar 

Garcimartín A, López-Oliva ME, Sántos-López JA, García-Fernández RA, Macho-González A, Bastida S, et al. Silicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high–saturated fat, high-cholesterol diet. J Nutr. 2017;147(6):1104–12.

Article  PubMed  Google Scholar 

Komorowski J, Ojalvo SP. A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males. FASEB J. 2016;30(S1):690.17–90.17. https://doi.org/10.1096/fasebj.30.1_supplement.690.17

Article