Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. https://doi.org/10.3322/caac.21660.

Article  CAS  PubMed  Google Scholar 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6:92. https://doi.org/10.1038/s41572-020-00224-3.

Article  PubMed  PubMed Central  Google Scholar 

Bhatia A, Burtness B. Treating head and neck cancer in the age of immunotherapy: a 2023 update. Drugs. 2023. https://doi.org/10.1007/s40265-023-01835-2.

Article  PubMed  Google Scholar 

Fasano M, Corte CMD, Liello RD, Viscardi G, Sparano F, Iacovino ML, et al. Immunotherapy for head and neck cancer: present and future. Crit Rev Oncol Hematol. 2022;174:103679. https://doi.org/10.1016/j.critrevonc.2022.103679.

Article  PubMed  Google Scholar 

Cramer JD, Burtness B, Le QT, Ferris RL. The changing therapeutic landscape of head and neck cancer. Nat Rev Clin Oncol. 2019;16:669–83. https://doi.org/10.1038/s41571-019-0227-z.

Article  PubMed  Google Scholar 

Singh P, Augustine D, Rao RS, Patil S, Awan KH, Sowmya SV, et al. Role of cancer stem cells in head-and-neck squamous cell carcinoma - a systematic review. J Carcinog. 2021;20:12. https://doi.org/10.4103/jcar.JCar_14_20.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Li B. Updates of liquid biopsy in oral cancer and multiomics analysis. Oral Dis. 2023;29:51–61. https://doi.org/10.1111/odi.14064.

Article  PubMed  Google Scholar 

Granato DC, Neves LX, Trino LD, Carnielli CM, Lopes AFB, Yokoo S, et al. Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients. Biochim Biophys Acta Proteins Proteom. 2021;1869:140659. https://doi.org/10.1016/j.bbapap.2021.140659.

Article  CAS  PubMed  Google Scholar 

Mishra V, Singh A, Chen X, Rosenberg AJ, Pearson AT, Zhavoronkov A, et al. Application of liquid biopsy as multi-functional biomarkers in head and neck cancer. Br J Cancer. 2022;126:361–70.

Article  PubMed  Google Scholar 

Papale F, Santonocito S, Polizzi A, Giudice AL, Capodiferro S, Favia G, et al. The new era of salivaomics in dentistry: frontiers and facts in the early diagnosis and prevention of oral diseases and cancer. Metabolites. 2022. https://doi.org/10.3390/metabo12070638.

Article  PubMed  PubMed Central  Google Scholar 

Sarhadi VK, Armengol G. Molecular biomarkers in cancer. Biomolecules. 2022. https://doi.org/10.3390/biom12081021.

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Hu C, Huang Z, Li Z, Zhang Q, He Y. In Silico screening of circulating tumor DNA, circulating microRNAs, and long non-coding RNAs as diagnostic molecular biomarkers in ovarian cancer: a comprehensive meta-analysis. PLoS ONE. 2021;16:e0250717. https://doi.org/10.1371/journal.pone.0250717.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hudečková M, Koucký V, Rottenberg J, Gál B. Gene mutations in circulating Tumour DNA as a diagnostic and prognostic marker in head and neck cancer-a systematic review. Biomedicines. 2021. https://doi.org/10.3390/biomedicines9111548.

Article  PubMed  PubMed Central  Google Scholar 

Aulakh SS, Silverman DA, Young K, Dennis SK, Birkeland AC. The promise of circulating tumor DNA in head and neck cancer. Cancers. 2022. https://doi.org/10.3390/cancers14122968.

Article  PubMed  PubMed Central  Google Scholar 

van Ginkel JH, Huibers MMH, van Es RJJ, de Bree R, Willems SM. Droplet digital PCR for detection and quantification of circulating tumor DNA in plasma of head and neck cancer patients. BMC Cancer. 2017;17:428. https://doi.org/10.1186/s12885-017-3424-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Diehl F, Dressman D, Vogelstein B, Kinzler KW. BEAMing up for detection and quantification of rare sequence variants. Nat Methods. 2006;3:95–7. https://doi.org/10.1038/nmeth850.

Article  CAS  PubMed  Google Scholar 

Nikanjam M, Kato S, Kurzrock R. Liquid biopsy: current technology and clinical applications. J Hematol Oncol. 2022;15:131. https://doi.org/10.1186/s13045-022-01351-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denis JA, Guillerm E, Coulet F, Larsen AK, Lacorte JM. The role of BEAMing and digital PCR for Multiplexed analysis in molecular oncology in the era of next-generation sequencing. Mol Diagn Ther. 2017;21:587–600. https://doi.org/10.1007/s40291-017-0287-7.

Article  CAS  PubMed  Google Scholar 

Perdomo S, Avogbe PH, Foll M, Abedi-Ardekani B, Facciolla VL, Anantharaman D, et al. Circulating tumor DNA detection in head and neck cancer: evaluation of two different detection approaches. Oncotarget. 2017;8:72621–32. https://doi.org/10.18632/oncotarget.20004.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, et al. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med. 2015;7:293ra104. https://doi.org/10.1126/scitranslmed.aaa8507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Satyal U, Srivastava A, Abbosh PH. Urine biopsy-liquid gold for molecular detection and surveillance of bladder Cancer. Front Oncol. 2019;9:1266. https://doi.org/10.3389/fonc.2019.01266.

Article  PubMed  PubMed Central  Google Scholar 

Bu J, Lee TH, Poellmann MJ, Rawding PA, Jeong WJ, Hong RS, et al. Tri-modal liquid biopsy: combinational analysis of circulating tumor cells, exosomes, and cell-free DNA using machine learning algorithm. Clin Transl Med. 2021;11:e499. https://doi.org/10.1002/ctm2.499.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kogo R, Manako T, Iwaya T, Nishizuka S, Hiraki H, Sasaki Y, et al. Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma. Cancer Med. 2022;11:3960–8. https://doi.org/10.1002/cam4.4726.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khandelwal AR, Greer AH, Hamiter M, Fermin JM, McMullen T, Moore-Medlin T, et al. Comparing cell-free circulating tumor DNA mutational profiles of disease-free and nonresponders patients with oropharyngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol. 2020;5:868–78. https://doi.org/10.1002/lio2.447.

Article  PubMed  PubMed Central  Google Scholar 

Burcher KM, Faucheux AT, Lantz JW, Wilson HL, Abreu A, Salafian K, et al. Prevalence of DNA repair gene mutations in blood and tumor tissue and impact on prognosis and treatment in HNSCC. Cancers. 2021. https://doi.org/10.3390/cancers13133118.

Article  PubMed  PubMed Central  Google Scholar 

Rettig EM, Faden DL, Sandhu S, Wong K, Faquin WC, Warinner C, et al. Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer. Int J Cancer. 2022;151:1081–5. https://doi.org/10.1002/ijc.33996.

Article  CAS  PubMed  Google Scholar 

Campo F, Zocchi J, Moretto S, Mazzola F, Petruzzi G, Donà MG, et al. Cell-free human papillomavirus-DNA for monitoring treatment response of head and neck squamous cell carcinoma: systematic review and meta-analysis. Laryngoscope. 2022;132:560–8. https://doi.org/10.1002/lary.29739.

Article  CAS  PubMed