Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer — viewpoint of the IARC working group. N Engl J Med. 2016;375:794–8.

Article  PubMed  PubMed Central  Google Scholar 

Ross R, Neeland IJ, Yamashita S, Shai I, Seidell J, Magni P, et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol. 2020;16:177–89.

Article  PubMed  PubMed Central  Google Scholar 

Pasco JA, Nicholson GC, Brennan SL, Kotowicz MA Prevalence of obesity and the relationship between the body mass index and body fat: cross-sectional, population-based data. PLoS One. 2012;7:e29580.

Janssen I, Shields M, Craig CL, Tremblay MS. Changes in the obesity phenotype within Canadian children and adults, 1981 to 2007-2009. Obesity. 2012;20:916–9.

Article  PubMed  Google Scholar 

Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, et al. Adiposity and cancer at major anatomical sites: Umbrella review of the literature. Vol. 356, BMJ (Online). BMJ Publishing Group; 2017.

Recalde M, Davila-Batista V, Díaz Y, Leitzmann M, Romieu I, Freisling H, et al. Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain. BMC Med. 2021;19:1–14.

Article  Google Scholar 

White AJ, Nichols HB, Bradshaw PT, Sandler DP. Overall and central adiposity and breast cancer risk in the sister study. Vol. 121, Cancer. NIH Public Access; 2015. p. 3700–8.

Freisling H, Arnold M, Soerjomataram I, O’Doherty MG, Ordóñez-Mena JM, Bamia C, et al. Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: Meta-analysis of individual participant data of seven prospective cohorts in Europe. Br J Cancer. 2017;116:1486–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barberio AM, Alareeki A, Viner B, Pader J, Vena JE, Arora P, et al. Central body fatness is a stronger predictor of cancer risk than overall body size. Nat Commun. 2019;10:383.

Abar L, Vieira AR, Aune D, Sobiecki JG, Vingeliene S, Polemiti E, et al. Height and body fatness and colorectal cancer risk: an update of the WCRF–AICR systematic review of published prospective studies. Eur J Nutr. 2018;57:1701–20.

Article  PubMed  Google Scholar 

MacInnis RJ, English DR. Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control. 2006;17:989–1003.

Article  PubMed  Google Scholar 

Harvie M, Hooper L, Howell AH. Central obesity and breast cancer risk: a systematic review. Obes Rev. 2003;4:157–73.

Article  CAS  PubMed  Google Scholar 

Aune D, Navarro Rosenblatt DA, Chan DSM, Vingeliene S, Abar L, Vieira AR, et al. Anthropometric factors and endometrial cancer risk: a systematic review and dose-response meta-analysis of prospective studies. Ann Oncol. 2015;26:1635–48.

Article  CAS  PubMed  Google Scholar 

Singh S, Sharma AN, Murad MH, Buttar NS, El-Serag HB, Katzka DA, et al. Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: A systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2013;11:1399–1412.e7.

Article  PubMed  Google Scholar 

Lee KR, Seo MH, Do Han K, Jung J, Hwang IC. Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults. Br J Cancer. 2018;119:1018–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tuomela J, Kaprio J, Sipilä PN, Silventoinen K, Wang X, Ollikainen M, et al. Accuracy of self-reported anthropometric measures-Findings from the Finnish Twin Study. Obes Res Clin Pr. 2019;13:522–8.

Article  CAS  Google Scholar 

Ascaso JF, Romero P, Real JT, Lorente RI, Martínez-Valls J, Carmena R. Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population. Eur J Intern Med. 2003;14:101–6.

Article  CAS  PubMed  Google Scholar 

Tabata S, Yoshimitsu S, Hamachi T, Abe H, Ohnaka K, Kono S. Waist circumference and insulin resistance: a cross-sectional study of Japanese men. BMC Endocr Disord. 2009;9:1.

Article  PubMed  PubMed Central  Google Scholar 

Crudele L, Piccinin E, Moschetta A. Visceral adiposity and cancer: Role in pathogenesis and prognosis. Vol. 13, Nutrients. Multidisciplinary Digital Publishing Institute (MDPI); 2021.

Hawwash NK, Sperrin M, Martin GP, Joshu CE, Florido R, Platz EA, et al. Overweight-years and cancer risk: a prospective study of the association and comparison of predictive performance with body mass index (atherosclerosis risk in communities study). Int J Cancer. 2023;154;1556–68.

PLCO-752: Adolescent and adulthood BMI And Cancer risk using obese-year metrics: … - Approved Projects - The Cancer Data Access System [Accessed 2022 Apr 3]. Available from: https://cdas.cancer.gov/approved-projects/2950/.

Wright JD, Folsom AR, Coresh J, Sharrett AR, Couper D, Wagenknecht LE, et al. The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8. J Am Coll Cardiol J Am Coll Cardiol. 2021;77:2939–59.

Article  PubMed  Google Scholar 

Joshu CE, Barber JR, Coresh J, Couper DJ, Mosley TH, Vitolins MZ, et al. Enhancing the infrastructure of the atherosclerosis risk in Communities (ARIC) study for cancer epidemiology research: Aric cancer. Cancer Epidemiol Biomark Prev. 2018;27:295–305.

Article  Google Scholar 

Wood AM, Jonsson H, Nagel G, Häggström C, Manjer J, Ulmer H, et al. The inverse association of body mass index with lung cancer: exploring residual confounding, metabolic aberrations and within-person variability in smoking. Cancer Epidemiol Biomark Prev. 2021;30:1489–97.

Article  Google Scholar 

Ferrario M, Carpenter MA, Chambless LE. Reliability of body fat distribution measurements. The ARIC study baseline cohort results. Int J Obes. 1995;19:449–57.

CAS  Google Scholar 

Riley RD, Ensor J, Snell KIE, Harrell FE, Martin GP, Reitsma JB, et al. Calculating the sample size required for developing a clinical prediction model. BMJ. 202018;368.

Morgan CJ. Landmark analysis: A primer. J Nucl Cardiol. 2019;26:391–3.

Article  PubMed  Google Scholar 

Campion WM, Rubin DB. Multiple Imputation for Nonresponse in Surveys. Rubin DB, editor. J Mark Res. 1989;26:485.

Google Scholar 

Lean MEJ, Han TS, Morrison CE. Waist circumference as a measure for indicating need for weight management. BMJ. 1995;311:158.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu D, Zheng W, Johansson M, Lan Q, Park Y, White E, et al. Overall and central obesity and risk of lung cancer: a pooled analysis. J Natl Cancer Inst. 2018;110:831–42.

Article  PubMed  PubMed Central  Google Scholar 

Aref AT, Vincent AD, O’Callaghan ME, Martin SA, Sutherland PD, Hoy AJ, et al. The inverse relationship between prostate specific antigen (PSA) and obesity. Endocr Relat Cancer. 2018;25:933–41.

Article  CAS  PubMed  Google Scholar 

Reis JP, Allen N, Gunderson EP, Lee JM, Lewis CE, Loria CM, et al. Excess body mass index- and waist circumference-years and incident cardiovascular disease: The CARDIA study. Obesity. 2015;23:879–85.

Article  PubMed  Google Scholar 

Henry L, Wickham H. purrr: Functional Programming Tools [Accessed 2021 Nov 15]. 2020. Available from: https://cran.r-project.org/package=purrr.

Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67.

Bache SM, Wickham H. magrittr: A Forward-Pipe Operator for R [Accessed 2021 Nov 15]. 2020. Available from: https://cran.r-project.org/package=magrittr.

Wickham H, Averick M, Bryan J, Chang W, McGowan L, François R, et al. Welcome to the Tidyverse. J Open Source Softw. 2019;4:1686.

Article  Google Scholar 

Wickham H, Miller E. haven: Import and Export “SPSS”, “Stata” and “SAS” Files [Accessed 2021 Nov 15]. 2021. Available from: https://cran.r-project.org/package=haven.

Therneau TM. A Package for Survival Analysis in R [Accessed 2021 Nov 15]. 2021. Available from: https://cran.r-project.org/package=survival.

Long JA interactions: Comprehensive, User-Friendly Toolkit for Probing Interactions [Accessed 2021 Nov 15]. 2019. Available from: https://cran.r-project.org/package=interactions.

Harrell Jr FE. rms: Regression Modeling Strategies [Accessed 2021 Nov 15]. 2022. Available from: https://cran.r-project.org/package=rms.

Wickham H. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York; 2016.

Kassambara A, Kosinski M, Biecek P. survminer: Drawing Survival Curves using “ggplot2” [Accessed 2021 Nov 15]. 2021. Available from: https://cran.r-project.org/package=survminer.

Grolemund G, Wickham H. Dates and Times Made Easy with . J Stat Softw. 2011;40:1–25.

Article  Google Scholar 

Kassambara A. ggpubr: “ggplot2” Based Publication Ready Plots [Accessed 2022 Jan 5]. 2020. Available from: https://cran.r-project.org/web/packages/ggpubr/index.html.

Sarkar D. Lattice: Multivariate Data Visualization with R. New York: Springer; 2008.

Heinzen E, Sinnwell J, Atkinson E, Gunderson T, Dougherty G arsenal: An Arsenal of “R” Functions for Large-Scale Statistical Summaries [Accessed 2022 Jan 5]. 2021. Available from: https://cran.r-project.org/package=arsenal.

Harrell Jr FE. Hmisc: Harrell Miscellaneous [Accessed 2022 Jan 5]. 2022. Available from: https://cran.r-project.org/package=Hmisc.

Zhu H. kableExtra: Construct Complex Table with “kable” and Pipe Syntax [Accessed 2022 Jan 5]. 2021. Available from: https://cran.r-project.org/package=kableExtra.

Sjoberg DD, Whiting K, Curry M, Lavery JA, Larmarange J. Reproducible Summary Tables with the gtsummary Package. R J. 2021;13:570–80.

Article  Google Scholar 

R Core Team. R: A language and environment for statistical computing [Accessed 2021 Nov 15]. 2021. Available from: https://www.r-project.org/.

Croissant Y, Graves S. Ecdat: Data Sets for Econometrics [Accessed 2022 Jan 5]. 2020. Available from: https://cran.r-project.org/package=Ecdat.

Kaplan J. R Markdown. In: A Criminologist’s Guide to R. 2022. p. 77–92.

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9.

Article  Google Scholar 

Fang Z, Giovannucci EL. The timing of adiposity and changes in the life course on the risk of cancer. Cancer Metastasis Rev. 2022;41:471–89.

Article