Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies

Alafuzoff I, Libard S (2024) Ageing-related neurodegeneration and cognitive decline. Int J Mol Sci. https://doi.org/10.3390/ijms25074065

Article  PubMed  PubMed Central  Google Scholar 

Arce Renteria M, Mobley TM, Evangelista ND, Medina LD, Deters KD, Fox-Fuller JT et al (2023) Representativeness of samples enrolled in Alzheimer’s disease research centers. Alzheimers Dement (Amst) 15:e12450. https://doi.org/10.1002/dad2.12450

Article  PubMed  Google Scholar 

Arnold SJ, Dugger BN, Beach TG (2013) TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies. Acta Neuropathol 126:51–57. https://doi.org/10.1007/s00401-013-1110-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J et al (2007) The national alzheimer’s coordinating center (NACC) database: the Uniform Data Set. Alzheimer Dis Assoc Disord 21:249–258

Article  PubMed  Google Scholar 

Beekly DL, Ramos EM, van Belle G, Deitrich W, Clark AD, Jacka ME et al (2004) The national Alzheimer’s coordinating center (NACC) database: an Alzheimer disease database. Alzheimer Dis Assoc Disord 18:270–277

PubMed  Google Scholar 

Bellenguez C, Kucukali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N et al (2022) New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet 54:412–436. https://doi.org/10.1038/s41588-022-01024-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett DA, Schneider JA, Arvanitakis Z, Wilson RS (2012) Overview and findings from the religious orders study. Curr Alzheimer Res 9:628–645. https://doi.org/10.2174/156720512801322573

Article  CAS  PubMed  PubMed Central  Google Scholar 

Besser L, Kukull W, Knopman DS, Chui H, Galasko D, Weintraub S et al (2018) Version 3 of the national Alzheimer’s coordinating center’s uniform data set. Alzheimer Dis Assoc Disord 32:351–358. https://doi.org/10.1097/WAD.0000000000000279

Article  PubMed  PubMed Central  Google Scholar 

Besser LM, Kukull WA, Teylan MA, Bigio EH, Cairns NJ, Kofler JK et al (2018) The revised national Alzheimer’s coordinating center’s neuropathology form-available data and new analyses. J Neuropathol Exp Neurol 77:717–726. https://doi.org/10.1093/jnen/nly049

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA et al (2019) Attributable risk of Alzheimer’s dementia attributed to age-related neuropathologies. Ann Neurol 85:114–124. https://doi.org/10.1002/ana.25380

Article  CAS  PubMed  Google Scholar 

Braak H, Thal DR, Ghebremedhin E, Del Tredici K (2011) Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960–969. https://doi.org/10.1097/NEN.0b013e318232a379

Article  CAS  PubMed  Google Scholar 

Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH et al (2009) Neuropathological correlates of dementia in over-80 year-old brain donors from the population-based Cambridge city over-75 s cohort (CC75C) study. J Alzheimers Dis 18:645–658. https://doi.org/10.3233/JAD-2009-1182

Article  PubMed  Google Scholar 

Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT (2014) Hippocampal sclerosis of aging is a key Alzheimer’s disease mimic: clinical-pathologic correlations and comparisons with both alzheimer’s disease and non-tauopathic frontotemporal lobar degeneration. J Alzheimers Dis 39:691–702. https://doi.org/10.3233/JAD-131880

Article  PubMed  PubMed Central  Google Scholar 

Butler Pagnotti RM, Pudumjee SB, Cross CL, Miller JB (2023) Cognitive and clinical characteristics of patients with limbic-predominant age-related TDP-43 encephalopathy. Neurology 100:e2027–e2035. https://doi.org/10.1212/WNL.0000000000207159

Article  PubMed  PubMed Central  Google Scholar 

Chang K, Ling JP, Redding-Ochoa J, An Y, Li L, Dean SA et al (2023) Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer’s disease neuropathologic changes and cognitive decline. Acta Neuropathol 147:4. https://doi.org/10.1007/s00401-023-02653-2

Article  CAS  PubMed  Google Scholar 

Coyle-Gilchrist IT, Dick KM, Patterson K, Vazquez Rodriquez P, Wehmann E, Wilcox A et al (2016) Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology 86:1736–1743. https://doi.org/10.1212/WNL.0000000000002638

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dooneief G, Marder K, Tang MX, Stern Y (1996) The Clinical Dementia Rating scale: community-based validation of “profound” and “terminal” stages. Neurology 46:1746–1749. https://doi.org/10.1212/wnl.46.6.1746

Article  CAS  PubMed  Google Scholar 

Dugan AJ, Nelson PT, Katsumata Y, Shade LMP, Boehme KL, Teylan MA et al (2021) Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. Acta Neuropathol Commun 9:152. https://doi.org/10.1186/s40478-021-01250-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farfel JM, Yu L, Buchman AS, Schneider JA, De Jager PL, Bennett DA (2016) Relation of genomic variants for Alzheimer disease dementia to common neuropathologies. Neurology 87:489–496. https://doi.org/10.1212/WNL.0000000000002909

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gauthreaux K, Kukull WA, Nelson KB, Mock C, Chen YC, Chan KCG et al (2023) Different cohort, disparate results: selection bias is a key factor in autopsy cohorts. Alzheimers Dement. https://doi.org/10.1002/alz.13422

Article  PubMed  PubMed Central  Google Scholar 

Genomes Project C, Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM et al (2010) A map of human genome variation from population-scale sequencing. Nature 467:1061–1073. https://doi.org/10.1038/nature09534

Article  CAS  Google Scholar 

Harrison WT, Lusk JB, Liu B, Ervin JF, Johnson KG, Green CL et al (2021) Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is independently associated with dementia and strongly associated with arteriolosclerosis in the oldest-old. Acta Neuropathol. https://doi.org/10.1007/s00401-021-02360-w

Article  PubMed  PubMed Central  Google Scholar 

Hiya S, Maldonado-Diaz C, Walker JM, Richardson TE (2023) Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease. J Neuropathol Exp Neurol 83:2–10. https://doi.org/10.1093/jnen/nlad098

Article  PubMed  PubMed Central  Google Scholar 

Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC et al (2012) National institute on Aging-Alzheimer’s association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers Dement 8:1–13. https://doi.org/10.1016/j.jalz.2011.10.007

Article  PubMed  Google Scholar 

Kapasi A, DeCarli C, Schneider JA (2017) Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol 134:171–186. https://doi.org/10.1007/s00401-017-1717-7

Article  PubMed  PubMed Central  Google Scholar 

Kapasi A, Yu L, Boyle PA, Barnes LL, Bennett DA, Schneider JA (2020) Limbic-predominant age-related TDP-43 encephalopathy, ADNC pathology, and cognitive decline in aging. Neurology 95:e1951–e1962. https://doi.org/10.1212/WNL.0000000000010454

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karanth S, Nelson PT, Katsumata Y, Kryscio RJ, Schmitt FA, Fardo DW et al (2020) Prevalence and clinical phenotype of quadruple misfolded proteins in older adults. JAMA Neurol 77:1299–1307. https://doi.org/10.1001/jamaneurol.2020.1741

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