Multi-functional Chitosan Polymeric Micelles for improving the oral bioavailability of Paclitaxel based on synergistic effect

Bashyal S, Seo JE, Choi YW, Lee S. Bile acid transporter-mediated oral absorption of insulin via hydrophobic ion-pairing approach. J Control Release. 2021;338:644–61.

Article  CAS  PubMed  Google Scholar 

de Souza GS, Mantovani DB, Mossel P, Haarman BC, da Silva AM, Boersma HH, Furini CR, Lammertsma AA, Tsoumpas C, Luurtsema G. Oral administration of PET tracers: Current status. J Control Release. 2023;357:591–605.

Article  Google Scholar 

Donoso-Meneses D, Figueroa-Valdés AI, Khoury M, Alcayaga-Miranda F. Oral administration as a potential alternative for the delivery of small extracellular vesicles. Pharmaceutics. 2023;15(3). https://doi.org/10.3390/pharmaceutics15030716.

Ahmed Khalil A, Rauf A, Alhumaydhi FA, Aljohani AS, Javed MS, Khan MA, Khan IA, El-Esawi MA, Bawazeer S, Bouyahya A, Rebezov M. Recent developments and anticancer therapeutics of paclitaxel: an update. Curr Pharm Design. 2022;28:3363–73.

Article  Google Scholar 

Kim JT, Barua S, Kim H, Hong S-C, Yoo S-Y, Jeon H, Cho Y, Gil S, Oh K, Lee J. Absorption study of genistein using solid lipid microparticles and nanoparticles: control of oral bioavailability by particle sizes. Biomolecules Ther. 2017;25:452–9.

Article  CAS  Google Scholar 

Kou L, Yao Q, Sun M, Wu C, Wang J, Luo Q, Wang G, Du Y, Fu Q, Wang J, He Z, Ganapathy V, Sun J. Cotransporting ion is a trigger for cellular endocytosis of transporter-targeting nanoparticles: a case study of high-efficiency Slc22a5 (Octn2)-mediated carnitine-conjugated nanoparticles for oral delivery of therapeutic drugs. Adv Healthc Mater. 2017;6(17). https://doi.org/10.1002/adhm.201700165.

Li J, Zhang Y, Yu M, Wang A, Qiu Y, Weiwei F, Hovgaard L, Yang M, Li Y, Wang R, Li X, Gan Y. The upregulated intestinal Folate transporters Direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery. Acta Pharm Sinica B. 2022;12:1460–72.

Article  CAS  Google Scholar 

Liu Q, Cheng M, Liang J, Jin Y, Feng J, Tu L. Enhancing oral bioavailability by paclitaxel polymeric micelles: role of transmembrane pathways in the oral absorption. J Biomed Nanotechnol. 2020;16:1160–8.

Article  CAS  PubMed  Google Scholar 

Ran Mo X, Jin N, Li C, Ju M, Sun C, Zhang, Ping Q. The mechanism of enhancement on oral absorption of paclitaxel by N-Octyl-O-Sulfate chitosan micelles. Biomaterials. 2011;32:4609–20.

Article  PubMed  Google Scholar 

Palle S, Neerati P. Enhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting Cyp3a4 and Esterases. Pharmacol Rep. 2017;69:365–70.

Article  CAS  PubMed  Google Scholar 

Lu Qin H, Wu E, Xu X, Zhang J, Guan R, Zhao, Mao S. Exploring the potential of functional polymer-lipid hybrid nanoparticles for enhanced oral delivery of paclitaxel. Asian J Pharm Sci. 2021;16:387–95.

Article  PubMed  PubMed Central  Google Scholar 

Qindeel M, Ahmed N, Khan GM, Rehman AU. Ligand decorated chitosan as an advanced nanocarrier for targeted delivery: a critical review. Nanomedicine. 2019;14:1623–42.

Article  CAS  PubMed  Google Scholar 

Rehman N, Khan A, Bibi I, Bica CI, Siddiq M. Intermolecular Interactions of polymer/surfactants mixture in aqueous solution investigated by various techniques. J Dispers Sci Technol. 2013;34:1202–10.

Article  CAS  Google Scholar 

Suan XY, Duan ZJ, Liu Z, Tang SX, Li Y, He SC, Wang QM, Chang QY. Inhibition of P-glycoprotein, multidrug resistance-associated protein 2 and cytochrome P450 3a4 improves the oral absorption of octreotide in rats with portal hypertension. ExpTher Med. 2016;12:3716–22.

Article  Google Scholar 

Wang C-C, Lin L-H, Lee H-T, Ye Y-W. Surface activity and micellization properties of chitosan-succinyl derivatives. Colloids Surf A Physicochemical Eng Aspects. 2011;389:246–53.

Article  CAS  Google Scholar 

Wang J, Li L, Wu L, Sun B, Du Y, Sun J, Wang Y, Fu Q, Zhang P, He Z. Development of novel self-assembled Es-Plga hybrid nanoparticles for improving oral absorption of doxorubicin hydrochloride by P-Gp inhibition: in vitro and in vivo evaluation. Eur J Pharm Sci. 2017;99:185–92.

Article  CAS  PubMed  Google Scholar 

Wang X, Guo Y, Qiu L, Wang X, Li T, Han L, Ouyang H, Xu W, Chu K. Preparation and evaluation of carboxymethyl chitosan-rhein polymeric micelles with synergistic antitumor effect for oral delivery of paclitaxel. Carbohydr Polym. 2019;206:121–31.

Article  CAS  PubMed  Google Scholar 

Wang Y, Wang G, Chen H, Sun Y, Sun M, Liu X, Jian W, He Z, Sun J. A facile di-acid mono-amidation strategy to prepare cyclization-activating mono-carboxylate transporter 1-targeting gemcitabine prodrugs for enhanced oral delivery. Int J Pharm. 2020;573. https://doi.org/10.1016/j.ijpharm.2019.118718.

Tan Yang J, Feng Q, Zhang W, Wu H, Mo L, Huang, Zhang W. L-Carnitine conjugated Chitosan-Stearic Acid Polymeric micelles for improving the oral bioavailability of Paclitaxel. Drug Delivery. 2020;27:575–84.

Article  PubMed  PubMed Central  Google Scholar 

Ni J, Tian F, Dahmani FZ, Yang H, Yue D, He S, Zhou J, Yao J. Curcumin-carboxymethyl chitosan (CNC) conjugate and CNC/LHR mixed polymeric micelles as new approaches to improve the oral absorption of P-gp substrate drugs. Drug Deliv. 2016;23:3424–35.

Article  CAS  PubMed  Google Scholar 

Zhou F, Huang W, Xu T, Wu L, Chen Q, Peng J, Liu X, Lu B. Natural P-gp inhibitor EGCG improves the acteoside absorption in Caco-2 cell monolayers and increases the oral bioavailability of acteoside in rats. Food Chem Toxicol. 2020;146. https://doi.org/10.1016/j.fct.2020.111827.

Sun XY, Duan ZJ, Liu Z, Tang SX, Li Y, He SC, Wang QM, Chang QY. Inhibition of P-glycoprotein, multidrug resistance-associated protein 2 and cytochrome P450 3A4 improves the oral absorption of octreotide in rats with portal hypertension. Exp Ther Med. 2016;12:3716–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Y, Chen Y, Li D, Lin S, Chen H, Wu W, Zhang W. Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter. Carbohydr Polym. 2023;300. https://doi.org/10.1016/j.carbpol.2022.120233.

Ying N, Liu S, Zhang M, Cheng J, Luo L, Jiang J, Shi G, Wu S, Ji J, Su H, Pan H, Zeng D. Nano delivery system for paclitaxel: recent advances in cancer theranostics. Colloids Surf B Biointerfaces. 2023;228. https://doi.org/10.1016/j.colsurfb.2023.113419.

Yoshie K, Ishihara K. Improvement of oral absorption of poorly water-soluble drugs by solid dispersions with amphiphilic phospholipid polymer. J Pharm Sci. 2022;111:3141–8.

Article  CAS  PubMed  Google Scholar 

Yu J, Chen H, Jiang L, Wang J, Dai J, Wang J. Codelivery of adriamycin and P-Gp inhibitor quercetin using Pegylated liposomes to overcome cancer drug resistance. J Pharm Sci. 2019;108:1788–99.

Article  CAS  PubMed  Google Scholar 

Zhong X, Yang J, Liu H, Yang Z, Luo P. Potential lipid-based strategies of amphotericin b designed for oral administration in clinical application. Drug Deliv. 2023;30(1). https://doi.org/10.1080/10717544.2022.2161671.

Zhou J, Zhang J, Sun Y, Luo F, Guan M, Ma H, Dong X, Feng J. A nano-delivery system based on preventing degradation and promoting absorption to improve the oral bioavailability of insulin. Int J Biol Macromol. 2023;244. https://doi.org/10.1016/j.ijbiomac.2023.125263.

Comments (0)

No login
gif