Alghasham A, Rasheed Z (2014) Therapeutic targets for rheumatoid arthritis: progress and promises. Autoimmunity 47(2):77–94

Google Scholar 

Amalraj A et al (2017) A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study. J Med Food 20(10):1022–1030

Google Scholar 

Bordy R et al (2018) Microvascular endothelial dysfunction in rheumatoid arthritis. Nat Rev Rheumatol 14(7):404–420

Google Scholar 

Dinesh P, Rasool M (2019) Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis 24(7):644–661

Google Scholar 

Dong B et al (2022) Berberine encapsulated in exosomes derived from platelet-rich plasma promotes chondrogenic differentiation of the bone marrow mesenchymal stem cells via the wnt/β-catenin pathway. Biol Pharm Bull 45(10):1444–1451

Google Scholar 

Fan X-X et al (2020) ROS-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria. Nano-Micro Lett 12:1–14

Google Scholar 

Haleagrahara N et al (2018) Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis. Inflammopharmacology 26:1219–1232

Google Scholar 

Ibrahim SSA et al (2021) Micro RNAs 26b, 20a inversely correlate with GSK-3 β/NF-κB/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis. Int Immunopharmacol 99:108042

Google Scholar 

Jiang T-T et al (2023) Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α. Inflamm Res 72(5):1021–1035

Google Scholar 

Kalani A, Chaturvedi P (2017) Curcumin-primed and curcumin-loaded exosomes: potential neural therapy. Neural Regen Res 12(2):205–206

Google Scholar 

Kim W et al (2000) The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA). Clin Exp Immunol 119(1):175–181

Google Scholar 

Lee DK, In J, Lee S (2015) Standard deviation and standard error of the mean. Korean J Anesthesiol 68(3):220–223

Google Scholar 

Li Z et al (2016) Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma. J Asthma 53(10):999–1005

Google Scholar 

Ling W et al (2023) Berberine reduce inflammation in RA rats through MCP1/CCR2 pathway. bioRxiv 2023.08.09.552722

Liu X et al (2023) Mechanism of action of quercetin in rheumatoid arthritis models: meta-analysis and systematic review of animal studies. Inflammopharmacology 31(4):1629–1645

Google Scholar 

Ma J-D et al (2014) Serum matrix metalloproteinase-3 as a noninvasive biomarker of histological synovitis for diagnosis of rheumatoid arthritis. Mediators Inflamm 2014(1):179284

Google Scholar 

Mohammadian Haftcheshmeh S, Momtazi-Borojeni AA (2021) Berberine as a promising natural compound for the treatment of periodontal disease: a focus on anti-inflammatory properties. J Cell Mol Med 25(24):11333–11337

Google Scholar 

Page MJ et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71

Google Scholar 

Peng X et al (2023) A sustained-release phospholipid-based phase separation gel loaded with berberine for treating rheumatoid arthritis. Front Pharmacol 14:1210129

Google Scholar 

Quan L-D et al (2008) The development of novel therapies for rheumatoid arthritis. Expert Opin Ther Pat 18(7):723–738

Google Scholar 

Roeleveld DM et al (2017) Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis. PLoS ONE 12(2):e0171757

Google Scholar 

Sánchez-Martín P, Komatsu M (2018) p62/SQSTM1—steering the cell through health and disease. J Cell Sci 131(21):jcs222836

Google Scholar 

Sun F et al (2023) Exosomes derived from berberine-treated bone marrow mesenchymal stem cells ameliorate inflammatory arthritis in rats with collagen-induced rheumatoid arthritis. Food Hydrocolloids 34(1):2220566

Google Scholar 

Syggelos SA et al (2013) Extracellular matrix degradation and tissue remodelling in periprosthetic loosening and osteolysis: focus on matrix metalloproteinases, their endogenous tissue inhibitors, and the proteasome. Biomed Res Int 2013(1):230805

Google Scholar 

Taverna S et al (2015) Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21. Oncotarget 6(26):21918

Google Scholar 

Tu J et al (2018) Ontology and function of fibroblast-like and macrophage-like synoviocytes: how do they talk to each other and can they be targeted for rheumatoid arthritis therapy? Front Immunol 9:1467

Google Scholar 

van der Worp HB, Sandercock PA (2012) Improving the process of translational research. BMJ 345(nov23 1):e7837

Google Scholar 

Vita AA et al (2021) Berberine delays onset of collagen-induced arthritis through T cell suppression. Int J Mol Sci 22(7):3522

Google Scholar 

Wang Z et al (2014) Berberine ameliorates collagen-induced arthritis in rats associated with anti-inflammatory and anti-angiogenic effects. Inflammation 37:1789–1798

Google Scholar 

Wang X et al (2017) Anti-arthritic effect of berberine on adjuvant-induced rheumatoid arthritis in rats. Biomed Pharmacother 89:887–893

Google Scholar 

Weyand CM, Goronzy JJ (2017) Immunometabolism in early and late stages of rheumatoid arthritis. Nat Rev Rheumatol 13(5):291–301

Google Scholar 

Xing R et al (2016) Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Clin Exp Immunol 184(2):147–158

Google Scholar 

Yue M et al (2017) Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut. FEBS J 284(17):2786–2801

Google Scholar 

Yue M et al (2019) The gut microbiota modulator berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply. FASEB J 33(11):12311

Google Scholar 

Zhang X-M et al (2018) Meta-analysis on efficacy and safety of combination therapy of Aconitum and Western medicine in treatment of rheumatoid arthritis. Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J Chin Materia Medica 43(2):227–233

Google Scholar 

Zhang L et al (2024) Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis. Clin Rheumatol 43(3):959–969

Google Scholar 

Zhou J et al (2019) Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-кB pathway. Eur J Pharmacol 852:179–188

Google Scholar