Disparities in treatment delays among metastatic breast cancer patients: insights from nationwide electronic health records, 2011–2022

Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74(1):12–49

Article  PubMed  Google Scholar 

Redig AJ, McAllister SS (2013) Breast cancer as a systemic disease: a view of metastasis. J Intern Med 274(2):113–126

Article  PubMed  PubMed Central  Google Scholar 

Mariotto AB, Etzioni R, Hurlbert M, Penberthy L, Mayer M (2017) Estimation of the number of women living with metastatic breast cancer in the United States. Cancer Epidemiol Biomark Prev 26(6):809–815

Article  Google Scholar 

Gogate A, Wheeler SB, Reeder-Hayes KE et al (2021) Projecting the prevalence and costs of metastatic breast cancer from 2015 through 2030. JNCI Cancer Spectrum 5(4):pkab063

Article  PubMed  PubMed Central  Google Scholar 

Chen L, Li CI (2015) Racial disparities in breast cancer diagnosis and treatment by hormone receptor and HER2 status. Cancer Epidemiol Biomark Prev 24(11):1666–1672

Article  Google Scholar 

Shavers VL, Harlan LC, Stevens JL (2003) Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer Interdiscip Int J Am Cancer Soc 97(1):134–147

Google Scholar 

CDC VitalSigns - Breast Cancer. Centers for Disease Control and Prevention. November 14, 2012. https://www.cdc.gov/vitalsigns/breastcancer/index.html. Accessed 14 Aug 2023

Puthanmadhom Narayanan S, Ren D, Oesterreich S, Lee AV, Rosenzweig MQ, Brufsky AM (2023) Effects of socioeconomic status and race on survival and treatment in metastatic breast cancer. NPJ Breast Cancer 9(1):90

Article  PubMed  PubMed Central  Google Scholar 

Song JH, Kantor O, Mittendorf EA, King TA, Minami CA (2022) Race and site of care impact treatment delays in older women with non-metastatic breast cancer. Ann Surg Oncol 29(7):4103–4114

Article  Google Scholar 

Hanna TP, King WD, Thibodeau S et al (2020) Mortality due to cancer treatment delay: systematic review and meta-analysis. bmj 371

Jung SY, Sereika SM, Linkov F, Brufsky A, Weissfeld JL, Rosenzweig M (2011) The effect of delays in treatment for breast cancer metastasis on survival. Breast Cancer Res Treat 130:953–964

Article  PubMed  Google Scholar 

Ho PJ, Cook AR, Binte Mohamed Ri NK, Liu J, Li J, Hartman M (2020) Impact of delayed treatment in women diagnosed with breast cancer: a population-based study. Cancer Med 9(7):2435–2444

Article  PubMed  PubMed Central  Google Scholar 

Shih NC, Kung PT, Kuo WY, Tsai WC (2022) Association of treatment delay and stage with mortality in breast cancer: a nationwide cohort study in Taiwan. Sci Rep 12(1):18915

Article  PubMed  PubMed Central  Google Scholar 

Weissman JS, Stern R, Fielding SL, Epstein AM (1991) Delayed access to health care: risk factors, reasons, and consequences. Published online 1991.

Syed ST, Gerber BS, Sharp LK (2013) Traveling towards disease: transportation barriers to health care access. J Community Health 38:976–993

Article  PubMed  PubMed Central  Google Scholar 

Jones R, Greenwood B (1994) Breast cancer: causes of patients’ distress identified by qualitative analysis. Br J Gen Pract 44(385):370–371

PubMed  PubMed Central  Google Scholar 

Rapoport Y, Kreitler S, Chaitchik S, Algor R, Weissler K (1993) Psychosocial problems in head-and-neck cancer patients and their change with time since diagnosis. Ann Oncol 4(1):69–73

Article  PubMed  Google Scholar 

Jiang C, Yabroff R, Deng L et al (2023) Beyond transportation: financial hardship, food insecurity, and care access barriers among US cancer survivors with transportation barriers to care. Published online 2023.

Caplan L (2014) Delay in breast cancer: implications for stage at diagnosis and survival. Front Public Health 2:87

Article  PubMed  PubMed Central  Google Scholar 

Ashing-Giwa KT, Gonzalez P, Lim J et al (2010) Diagnostic and therapeutic delays among a multiethnic sample of breast and cervical cancer survivors. Cancer 116(13):3195–3204

Article  PubMed  Google Scholar 

Bilimoria KY, Ko CY, Tomlinson JS et al (2011) Wait times for cancer surgery in the United States: trends and predictors of delays. Ann Surg 253(4):779–785

Article  PubMed  Google Scholar 

Etzioni DA, Liu JH, Maggard MA, O’Connell JB, Ko CY (2003) Workload projections for surgical oncology: will we need more surgeons? Ann Surg Oncol 10:1112–1117

Article  PubMed  Google Scholar 

Waskom ML, Tan K, Wiberg H, Cohen AB, Wittmershaus B, Shapiro W (2023) A hybrid approach to scalable real-world data curation by machine learning and human experts. Published online March 8, 2023:2023.03.06.23286770. https://doi.org/10.1101/2023.03.06.23286770

Griffith SD, Miksad RA, Calkins G et al (2019) Characterizing the feasibility and performance of real-world tumor progression end points and their association with overall survival in a large advanced non-small-cell lung cancer data set. JCO Clin Cancer Inform 3:1–13. https://doi.org/10.1200/CCI.19.00013

Article  PubMed  Google Scholar 

Ma X, Long L, Moon S, Adamson BJS, Baxi SS (2023) Comparison of population characteristics in real-world clinical oncology databases in the US: Flatiron Health, SEER, and NPCR. Published online June 7, 2023:2020.03.16.20037143. https://doi.org/10.1101/2020.03.16.20037143

Birnbaum B, Nussbaum N, Seidl-Rathkopf K et al (2020) Model-assisted cohort selection with bias analysis for generating large-scale cohorts from the EHR for oncology research. Published online January 13, 2020. https://doi.org/10.48550/arXiv.2001.09765

DeMichele A, Cristofanilli M, Brufsky A et al (2021) Comparative effectiveness of first-line palbociclib plus letrozole versus letrozole alone for HR+/HER2− metastatic breast cancer in US real-world clinical practice. Breast Cancer Res 23:37. https://doi.org/10.1186/s13058-021-01409-8

Article  PubMed  PubMed Central  Google Scholar 

StataCorp (2019) Stata statistical software: release 16. Published online 2019

Kuhlthau KA, Nipp RD, Shui A et al (2016) Health insurance coverage, care accessibility and affordability for adult survivors of childhood cancer: a cross-sectional study of a nationally representative database. J Cancer Surviv 10:964–971

Article  PubMed  PubMed Central  Google Scholar 

Zavala VA, Bracci PM, Carethers JM et al (2021) Cancer health disparities in racial/ethnic minorities in the United States. Br J Cancer 124(2):315–332

Article  PubMed  Google Scholar 

Salman A, Nguyen C, Lee YH, Cooksey-James T (2016) A review of barriers to minorities’ participation in cancer clinical trials: implications for future cancer research. J Immigr Minor Health 18:447–453

Article  PubMed  Google Scholar 

Mandelblatt JS, Yabroff KR, Kerner JF (1999) Equitable access to cancer services: a review of barriers to quality care. Cancer Interdiscip Int J Am Cancer Soc 86(11):2378–2390

Google Scholar 

Mullins CD, Blatt L, Gbarayor CM, Yang HWK, Baquet C (2005) Health disparities: a barrier to high-quality care. Am J Health Syst Pharm 62(18):1873–1882

Article  PubMed  Google Scholar 

Adamson AS, Zhou L, Baggett CD, Thomas NE, Meyer AM (2017) Association of delays in surgery for melanoma with insurance type. JAMA Dermatol 153(11):1106–1113

Article  PubMed  PubMed Central  Google Scholar 

Stokes SM, Wakeam E, Swords DS, Stringham JR, Varghese TK Jr (2018) Impact of insurance status on receipt of definitive surgical therapy and posttreatment outcomes in early stage lung cancer. Surgery 164(6):1287–1293

Article  PubMed  Google Scholar 

Kyle MA, Keating NL (2024) Prior authorization and association with delayed or discontinued prescription fills. J Clin Oncol 42(8):951–960

Article  PubMed  Google Scholar 

Gupta R, Fein J, Newhouse JP, Schwartz AL (2024) Comparison of prior authorization across insurers: cross sectional evidence from Medicare Advantage. BMJ. Published online March 7, 2024: e077797. https://doi.org/10.1136/bmj-2023-077797

Schwartz AL, Brennan TA, Verbrugge DJ, Newhouse JP (2021) Measuring the scope of prior authorization policies: applying private insurer rules to Medicare Part B. JAMA Health Forum 2(5):e210859. https://doi.org/10.1001/jamahealthforum.2021.0859

Article  PubMed  PubMed Central  Google Scholar 

Jones LA, Ferrans CE, Polite BN et al (2017) Examining racial disparities in colon cancer clinical delay in the Colon Cancer Patterns of Care in Chicago study. Ann Epidemiol 27(11):731–738

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif