Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Prim. 2020;6:92.

Article  PubMed  Google Scholar 

Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, et al. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell. 2017;171:1611–24 e24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma-an update. CA Cancer J Clin. 2015;65:401–21.

Article  PubMed  Google Scholar 

Santarelli RL, Pierre F, Corpet DE. Processed Meat and Colorectal Cancer: A Review of Epidemiologic and Experimental Evidence. Nutr Cancer. 2008;60:131–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clinton SK, Giovannucci EL, Hursting SD. The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. J Nutr. 2019;150:663–71.

Article  PubMed Central  Google Scholar 

Pascual G, Dominguez D, Elosua-Bayes M, Beckedorff F, Laudanna C, Bigas C, et al. Dietary palmitic acid promotes a prometastatic memory via Schwann cells. Nature. 2021;599:485–90.

Article  CAS  PubMed  Google Scholar 

De Mey E, De Maere H, Paelinck H, Fraeye I. Volatile N-nitrosamines in meat products: Potential precursors, influence of processing, and mitigation strategies. Crit Rev Food Sci Nutr. 2017;57:2909–23.

Article  PubMed  Google Scholar 

Carlstrom M, Montenegro MF. Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease. J Intern Med. 2019;285:2–18.

Article  CAS  PubMed  Google Scholar 

Carlström M. Nitric oxide signalling in kidney regulation and cardiometabolic health. Nat Rev Nephrol. 2021;17:575–90.

Article  PubMed  PubMed Central  Google Scholar 

Dhayade S, Kaesler S, Sinnberg T, Dobrowinski H, Peters S, Naumann U. et al. Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth. Cell Rep. 2016;14:2599–610.

Lv Y, Wang X, Li X, Xu G, Bai Y, Wu J, et al. Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway. PLoS Biol. 2020;18:e3000872.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gallo O, Masini E, Morbidelli L, Franchi A, Fini-Storchi I, Vergari WA, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst. 1998;90:587–96.

Article  CAS  PubMed  Google Scholar 

Torborg SR, Li Z, Chan JE, Tammela T. Cellular and molecular mechanisms of plasticity in cancer. Trends Cancer. 2022;8:735–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shabo I, Svanvik J. Expression of macrophage antigens by tumor cells. Adv Exp Med Biol. 2011;714:141–50.

Article  CAS  PubMed  Google Scholar 

Steinert G, Schölch S, Niemietz T, Iwata N, García SA, Behrens B, et al. Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer. Cancer Res. 2014;74:1694–704.

Article  CAS  PubMed  Google Scholar 

Tanuma J, Hiai H, Shisa H, Hirano M, Semba I, Nagaoka S, et al. Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity. Int J Cancer. 2002;102:638–42.

Article  CAS  PubMed  Google Scholar 

Carvalho L, Guimarães DD, Flôr AFL, Leite EG, Ruiz CR, de Andrade JT, et al. Effects of chronic dietary nitrate supplementation on longevity, vascular function and cancer incidence in rats. Redox Biol. 2021;48:102209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Zhuge Z, Carvalho L, Braga VA, Lucena RB, Li S, et al. Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway. Redox Biol. 2022;51:102266.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng J, Hu Q, Chen X, Wang C, Zhang J, Ren X, et al. Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells. Cell Death Dis. 2021;12:946.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen D, Wu M, Li Y, Chang I, Yuan Q, Ekimyan-Salvo M, et al. Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. Cell Stem Cell. 2017;20:621–34.e6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta S, Jawanda MK. Oral submucous fibrosis: An overview of a challenging entity. Indian J Dermatol Venereol Leprol. 2021;87:768–77.

Article  PubMed  Google Scholar 

Sequeira I, Rashid M, Tomás IM, Williams MJ, Graham TA, Adams DJ, et al. Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology. Nat Commun. 2020;11:5671.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Zhang F, Hua M, Song X, Liu S, Dong Z. Prognostic value of lymphatic vessel density in oral squamous cell carcinoma. Life Sci. 2021;265:118746.

Article  CAS  PubMed  Google Scholar 

Jang JY, Koh YJ, Lee SH, Lee J, Kim KH, Kim D, et al. Conditional ablation of LYVE-1+ cells unveils defensive roles of lymphatic vessels in intestine and lymph nodes. Blood. 2013;122:2151–61.

Article  CAS  PubMed  Google Scholar 

Pan D, Jia D. Application of Single-Cell Multi-Omics in Dissecting Cancer Cell Plasticity and Tumor Heterogeneity. Front Mol Biosci. 2021;8:757024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cowman MK, Lee HG, Schwertfeger KL, McCarthy JB, Turley EA. The Content and Size of Hyaluronan in Biological Fluids and Tissues. Front Immunol. 2015;6:261.

Article  PubMed  PubMed Central  Google Scholar 

O’Reilly D, Quinn CM, El-Shanawany T, Gordon S, Greaves DR. Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner. J Biol Chem. 2003;278:21909–19.

Article  PubMed  Google Scholar 

Kim MP, Li X, Deng J, Zhang Y, Dai B, Allton KL, et al. Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis. Cancer Discov. 2021;11:2094–111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li BX, Gardner R, Xue C, Qian DZ, Xie F, Thomas G, et al. Systemic Inhibition of CREB is Well-tolerated in vivo. Sci Rep. 2016;6:34513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie F, Li BX, Kassenbrock A, Xue C, Wang X, Qian DZ, et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015;58:5075–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crowe W, Pan X, Mackle J, Harris A, Hardiman G, Elliott CT, et al. Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology and alters metabolism in APC(min) mice. NPJ Sci Food. 2022;6:60.

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