Phellopterin Mitigates Cerebral Ischemia–Reperfusion Injury in Mice via NF-κB, COX-2 Inflammatory Pathway and OGD/R-Induced SH-SY5Y Cells

Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM (1986) Evaluation of 2,3,5-triphenyltetra-zolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304–1308. https://doi.org/10.1161/01.str.17.6.1304

Article  CAS  PubMed  Google Scholar 

Campbell BCV, Donnan GA, Lees KR, Hacke W, Khatri P, Hill MD, Goyal M, Mitchell PJ, Saver JL, Diener HC, Davis SM (2015) Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke. Lancet Neurol 14:846–854. https://doi.org/10.1016/S1474-4422(15)00140-4

Article  PubMed  Google Scholar 

Chamorro A, Dirnagl U, Urra X, Planas AM (2016) Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol 15:869–881. https://doi.org/10.1016/S1474-4422(16)00114-9

Article  CAS  PubMed  Google Scholar 

Chen H, He Y, Chen S, Qi S, Shen J (2020a) Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: applications for natural product efficacy with omics and systemic biology. Pharmacol Res 2020:158. https://doi.org/10.1016/j.phrs.2020.104877

Article  CAS  Google Scholar 

Chen KY, Wu KC, Hueng DY, Huang KF, Pang CY (2020b) Anti-inflammatory effects of powdered product of Bu Yang Huan Wu decoction: possible role in protecting against transient focal cerebral ischemia. Int J Med Sci 17:1854–1863. https://doi.org/10.7150/ijms.46581

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Wu J, Zhu J, Yang G, Tian J, Zhao Y, Wang Y (2021) Artesunate provides neuroprotection against cerebral ischemia-reperfusion injury via the TLR-4/NF-κB pathway in rats. Biol Pharm Bull 44:350–356. https://doi.org/10.1248/bpb.b20-00604

Article  CAS  PubMed  Google Scholar 

Chen X, Zhang Y, Pei J, Zeng X, Yang Y, Zhang Y, Li F, Deng Y (2022) Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes. Int Immunopharmacol 112:109270. https://doi.org/10.1016/j.intimp.2022.109270

Article  CAS  PubMed  Google Scholar 

Cheng JW, Zhang XJ, Cheng LS, Li GY, Zhang LJ, Ji KX, Zhao Q, Bai Y (2018) Low-dose tissue plasminogen activator in acute ischemic stroke: a systematic review and meta-analysis. J Stroke Cerebrovasc Dise 27:381–390. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.09.014

Article  Google Scholar 

Cui C, Jiang X, Wang Y, Li C, Lin Z, Wei Y, Ni Q (2024) Cerebral hypoxia-induced molecular alterations and their impact on the physiology of neurons and dendritic spines: a comprehensive review. Cell Mol Neurobiol 44:58. https://doi.org/10.1007/s10571-024-01491-4

Article  PubMed  PubMed Central  Google Scholar 

Dey A, Kang X, Qiu J, Du Y, Jiang J (2016) Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside. Trends Pharmacol Sci 37:463–484. https://doi.org/10.1016/j.tips.2016.03.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng S, Yang M, Liu S, He Y, Deng S, Gong Y (2023) Oxidative stress as a bridge between age and stroke: a narrative review. J Intensive Med 3:313–319. https://doi.org/10.1016/j.jointm.2023.02.002

Article  PubMed  PubMed Central  Google Scholar 

Franke M, Bieber M, Kraft P, Weber A, Stoll G, Schuhmann MK (2021) The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92:223–233. https://doi.org/10.1016/j.bbi.2020.12.009

Article  CAS  PubMed  Google Scholar 

Gao W, Ning Y, Peng Y, Tang X, Zhong S, Zeng H (2021) LncRNA NKILA relieves astrocyte inflammation and neuronal oxidative stress after cerebral ischemia/reperfusion by inhibiting the NF-κB pathway. Mol Immunol 139:32–41. https://doi.org/10.1016/j.molimm.2021.08.002

Article  CAS  PubMed  Google Scholar 

Guo MF, Zhang HY, Zhang PJ, Yu JW, Meng T, Li MD, Li N, Ma CH, Song LY, Yu JZ (2023) Fasudil alleviates cerebral ischemia‑reperfusion injury by inhibiting inflammation and improving neurotrophic factor expression in rats. Acta Neurobiol Exp 83:97‐110. https://doi.org/10.55782/ane-2023-010

Han HS, Jeon H, Kang SC (2018) Phellopterin isolated from Angelica dahurica reduces blood glucose level in diabetic mice. Heliyon 4:e00577. https://doi.org/10.1016/j.heliyon.2018.e00577

Article  PubMed  PubMed Central  Google Scholar 

Hiskens MI, Schneiders AG, Fenning AS (2024) Selective COX-2 inhibitors as neuroprotective agents in traumatic brain injury. Biomedicines 12:1930. https://doi.org/10.3390/biomedicines12081930

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Li Y, Pan H, Han L (2023) Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide. J Glob Health 13:04160. https://doi.org/10.7189/jogh.13.04160

Article  PubMed  PubMed Central  Google Scholar 

Jiang J, Yu Y (2021) Small molecules targeting cyclooxygenase/prostanoid cascade in experimental brain ischemia: Do they translate? Med Res Rev 41:828–857. https://doi.org/10.1002/med.21744

Article  CAS  PubMed  Google Scholar 

Kalogeris T, Baines CP, Krenz M, Korthuis RJ (2016) Ischemia/reperfusion. Compr Physiol 7:113–170. https://doi.org/10.1002/cphy.c160006

Article  PubMed  Google Scholar 

Kamal FZ, Lefter R, Jaber H, Balmus IM, Ciobica A, Iordache AC (2023) The role of potential oxidative biomarkers in the prognosis of acute ischemic stroke and the exploration of antioxidants as possible preventive and treatment options. Int J Mol Sci 24:6389. https://doi.org/10.3390/ijms24076389

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krishnamurthi RV, Ikeda T, Feigin VL (2020) Global, regional and country-specific burden of ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage: a systematic analysis of the global burden of disease study 2017. Neuroepidemiology 54:171–179. https://doi.org/10.1159/000506396

Article  PubMed  Google Scholar 

Kwon HS, Koh SH (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9:42. https://doi.org/10.1186/s40035-020-00221-2

Article  PubMed  PubMed Central  Google Scholar 

Leger PL, Pansiot J, Besson V, Palmier B, Renolleau S, Baud O, Cauli B, Charriaut-Marlangue C (2016) Cyclooxygenase-2-derived prostaglandins mediate cerebral microcirculation in a juvenile ischemic rat model. Stroke 47:3048–3052. https://doi.org/10.1161/STROKEAHA.116.015095

Article  CAS  PubMed  Google Scholar 

Li P, Stetler RA, Leak RK, Shi Y, Li Y, Yu W, Bennett MVL, Chen J (2018) Oxidative stress and DNA damage after cerebral ischemia: potential therapeutic targets to repair the genome and improve stroke recovery. Neuropharmacol 134:208–217. https://doi.org/10.1016/j.neuropharm.2017.11.011

Article  CAS  Google Scholar 

Li Z, Bi R, Sun S, Chen S, Chen J, Hu B, Jin H (2022) The role of oxidative stress in acute ischemic stroke-related thrombosis. Oxid Med Cell Longev 2022:8418820. https://doi.org/10.1155/2022/8418820

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma H, Jiang Z, Xu J, Liu J, Guo Z (2021) Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke. Drug Deliv 28:357–371. https://doi.org/10.1080/10717544.2021.1879315

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malko P, Jia X, Wood I, Jiang LH (2023) Piezo1 channel-mediated Ca2+ signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-α and IL-6 in microglial cells. Glia 71:848–865. https://doi.org/10.1002/glia.24311

Article  CAS  PubMed  Google Scholar 

Mao L, Wu DH, Hu GH, Fan JH (2023) TLR4 Enhances cerebral ischemia/reperfusion injury via regulating NLRP3 inflammasome and autophagy. Mediators Inflamm 2023:9335166. https://doi.org/10.1155/2023/9335166

Article  CAS  PubMed  PubMed Central 

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