McCabe MP, Sharlip ID, Atalla E, Balon R, Fisher AD, Laumann E, et al. Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J Sex Med. 2016;13:135–43.

Article  PubMed  Google Scholar 

Corona G, Lee DM, Forti G, O’connor DB, Maggi M, O’neill TW, et al. Age-related changes in general and sexual health in middle-aged and older men: results from the European male ageing study (EMAS). J Sex Med. 2010;7:1362–80.

Article  PubMed  Google Scholar 

McKinlay J. The worldwide prevalence and epidemiology of erectile dysfunction. Int J Impot Res. 2000;12:S6–11.

Article  PubMed  Google Scholar 

Malavige LS, Jayaratne SD, Kathriarachchi ST, Sivayogan S, Ranasinghe P, Levy JC. Erectile dysfunction is a strong predictor of poor quality of life in men with Type 2 diabetes mellitus. Diabet Med. 2014;31:699–706.

Article  CAS  PubMed  Google Scholar 

Meyer J‐P, Gillatt DA, Lockyer R, Macdonagh R. The effect of erectile dysfunction on the quality of life of men after radical prostatectomy. BJU Int. 2003;92:929–31.

Article  PubMed  Google Scholar 

Litwin MS, Nied RJ, Dhanani N. Health-related quality of life in men with erectile dysfunction. J Gen Intern Med. 1998;13:159–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Zhang Y, Ma M, Liu F, Shang Y, Yuan Q, et al. Does erectile dysfunction predict cardiovascular risk? a cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease. Front Cardiovasc Med. 2024;11:1341819.

Article  PubMed  PubMed Central  Google Scholar 

Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European association of Urology Guidelines on Sexual and Reproductive Health—2021 update: male sexual dysfunction. Eur Urol. 2021;80:333–57.

Article  PubMed  Google Scholar 

Hatzimouratidis K, Hatzichristou D. Phosphodiesterase type 5 inhibitors: The day after. Eur Urol. 2007;51:75–89.

Article  CAS  PubMed  Google Scholar 

Belew D, Klaassen Z, Lewis RW. Intracavernosal Injection for the diagnosis, evaluation, and treatment of erectile dysfunction: a review. Sex Med Rev. 2015;3:11–23.

Article  PubMed  Google Scholar 

Al Demour S, Adwan S, Jafar H, Alhawari H, Awidi A. Stem cell therapy in diabetic men with erectile dysfunction: a 24-month follow-up of safety and efficacy of two intracavernous autologous bone marrow derived mesenchymal stem cells injections, an open label phase 2 clinical trial. Basic Clin Androl. 2024;34:13.

Article  PubMed  PubMed Central  Google Scholar 

Poulios E, Mykoniatis I, Pyrgidis N, Zilotis F, Kapoteli P, Kotsiris D, et al. Platelet-rich plasma (PRP) improves erectile function: a double-blind, randomized, placebo-controlled clinical trial. J Sex Med. 2021;18:926–35.

Article  PubMed  Google Scholar 

Wessells H, Levine N, Hadley M, Dorr R, Hruby V. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000;12:S74–9.

Article  PubMed  Google Scholar 

Van Kampen M, De Weerdt W, Claes H, Feys H, De Maeyer M, Van Poppel H. Treatment of erectile dysfunction by perineal exercise, electromyographic biofeedback, and electrical stimulation. Phys Ther. 2003;83:536–43.

Article  PubMed  Google Scholar 

Derouet H, Nolden W, Jost WH, Osterhage J, Eckert RE, Ziegler M. Treatment of erectile dysfunction by an external ischiocavernous muscle stimulator. Eur Urol. 1998;34:355–9.

Article  CAS  PubMed  Google Scholar 

Stief CG, Weller E, Noack T, Djamilian M, Meschi M, Truss M, et al. Functional electromyostimulation of the corpus cavernosum penis? preliminary results of a novel therapeutic option for erectile dysfunction. World J Urol. 1995;13:243–7.

Article  CAS  PubMed  Google Scholar 

Hurt KJ, Sezen SF, Lagoda GF, Musicki B, Rameau GA, Snyder SH, et al. Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci USA. 2012;109:16624–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun. 1990;170:843–50.

Article  CAS  PubMed  Google Scholar 

Steers WD, Mallory B, de Groat WC. Electrophysiological study of neural activity in penile nerve of the rat. Am J Physiol. 1988;254:R989–1000.

CAS  PubMed  Google Scholar 

Shafik A, Shafik AA, Shafik IA, El Sibai O. Percutaneous perineal electrostimulation induces erection: clinical significance in patients with spinal cord injury and erectile dysfunction. J Spinal Cord Med. 2008;31:40–3.

Article  PubMed  PubMed Central  Google Scholar 

Yang CC, Bradley WE. Reflex innervation of the bulbocavernosus muscle. BJU Int. 2000;85:857–63.

Article  CAS  PubMed  Google Scholar 

Lombardi G, Nelli F, Mencarini M, Del Popolo G. Clinical concomitant benefits on pelvic floor dysfunctions after sacral neuromodulation in patients with incomplete spinal cord injury. Spinal Cord. 2011;49:629–36.

Article  CAS  PubMed  Google Scholar 

Lombardi G, Mondaini N, Giubilei G, Macchiarella A, Lecconi F, Del Popolo G. Sacral neuromodulation for lower urinary tract dysfunction and impact on erectile function. J Sex Med. 2008;5:2135–40.

Article  PubMed  Google Scholar 

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10:89.

Article  PubMed  PubMed Central  Google Scholar 

Deeks J, Higgins J, Altman D. Analysing data and undertaking meta-analyses. In: Higgins, JP, Thomas, J, Chandler, J, Cumpston M, Li T, Page M, et al. editors. Cochrane handbook for systematic reviews of interventions version 6.2. Cochrane; 2021. Available from www.training.cochrane.org/handbook.

Schünemann H, Brożek J, Guyatt G, Oxman A. editors. GRADE handbook for grading quality of evidence and strength of recommendations. The GRADE working group, 2013. Available from www.guidelinedevelopment.org/handbook.

Schünemann H, Higgins J, Vist G, Glasziou P, Akl E, Skoetz N, et al. editors. Completing ‘Summary of findings’ tables and grading the certainty of the evidence. In: Cochrane handbook for systematic reviews of interventions version 6.0. Cochrane, 2019. Available from www.training.cochrane.org/handbook.

Agasarov LG, Gyrskoĭ RA. Combination of clinical homeopathy and dynamic neurostimulation for the restoration of male sexual function. Vopr Kurortol Fizioter Lech Fiz Kult. 2010;1:29–31.

Karpukhin IV, Bobkova AS, Krasnikov VE, Vasil’ev EA, Vishniakov AI. The use of sinusoidal modulated currents in treating patients with the neuroreceptor form of impotence. Vopr Kurortol Fizioter Lech Fiz Kult. 1991;5:33–5.

Guskov AR, Vasiliev AI. An electrostimulator to restore sexual function in chronic prostatitis patients. Med Prog Technol. 1992;18:43–6.

CAS  PubMed  Google Scholar 

Kushniruk II, Skripal’ IA. Rectal electrostimulation of the prostate in complex treatment of coitus disturbances in men. Urol Nefrol. 1977;1:62–4.

Bispo AP, Nascimento S, Soler R. PD28-03 effects of functional electrostimulation on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomized sham-controlled study. J Urol. 2019;201(Supplement4):e487.

Bispo A. Clinical trial: identifier RBR-683dtp evaluation of the effect of electrical stimulation on erectile dysfunction after prostate cancer surgery. Rio de Janeiro (RJ): Instituto de Informação Científica e Tecnológica em Saúde Brazil [Internet]. 2017. https://ensaiosclinicos.gov.br/rg/RBR-683dtp. Assessed 29 Oct 2024.

Redshaw J, Lenherr S, Elliott S, Stoffel J, Rosenbluth J, Presson A, et al. Protocol for a randomized clinical trial investigating early sacral nerve stimulation as an adjunct to standard neurogenic bladder management following acute spinal cord injury. BMC Urol. 2018;18:72.

Article  PubMed  PubMed Central  Google Scholar 

Wu L, Cui C, Han J. Effect of 2/100 Hz transcutaneous electrical nerve stimulation on sexual dysfunction and serum sex hormone of heroin addicts. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20:15–8.

CAS  PubMed  Google Scholar 

Phillips A. National Library of Medicine (US). Clinical trial: identifier NCT03924388 spinal cord stimulation and autonomic response in people with SCI. https://clinicaltrials.gov/ct2/show/NCT03924388. Assessed 29 Oct 2024.

Potturi G, Vajrala K, Agarwal A. Effect of functional electrical stimulation on erectile dysfunction in post – stroke survivors- a randomized cinical control trail. Arch Physiother Rehabil. 2020;3:9–17.

Laurienzo CE, Magnabosco WJ, Jabur F, Faria EF, Gameiro MO, Sarri AJ, et al. Pelvic floor muscle training and electrical stimulation as rehabilitation after radical prostatectomy: a randomized controlled trial. J Phys Ther Sci. 2018;30:825–31.

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Liu J, Liu P, Zhang Y, Han W. Effects of electroacupuncture with different waveforms on chronic prostatitis/chronic pelvic pain syndromes: a randomized controlled trial. Hashmi MF, editor. Contrast media mol imaging. 2022;2022:1–7.

Contrast Media Molecular Imaging. Retracted: effects of electroacupuncture with different waveforms on chronic prostatitis/chronic pelvic pain syndromes: a randomized controlled trial. Contrast Media Mol Imaging. 2023;2023:9838623.

PubMed  PubMed Central  Google Scholar 

Carboni C. National library of medicine (US) clinical trial: identifier NCT02284659 effect of functional electrical stimulation on erectile dysfunction. 2014.