Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B (2014) Inhibiting DNA Methylation by 5-Aza-2′-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology 155(12):4925–4938

Article  PubMed  PubMed Central  Google Scholar 

Cazzanelli P, Wuertz-Kozak K (2020) MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. Int J Mol Sci 21(10):3601

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen CC, Wang KY, Shen CK (2013) “DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases. J Biol Chem 288(13):9084–9091

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Chen X, Yao J, Li M, Yang X (2019) The combination of Decitabine and EPZ-6438 effectively facilitate adipogenic differentiation of induced pluripotent stem cell-derived mesenchymal stem cells. Biochem Biophys Res Commun 516(1):307–312

Article  CAS  PubMed  Google Scholar 

Chen S, Liu S, Ma K, Zhao L, Lin H, Shao Z (2019b) TGF-β signaling in intervertebral disc health and disease. Osteoarthritis Cartilage 27(8):1109–1117

Article  CAS  PubMed  Google Scholar 

Cheng P, Wei HZ, Chen HW, Wang ZQ, Mao P, Zhang HH (2023) DNMT3a-mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF-κB pathway. J Cell Mol Med 2:e18048

Google Scholar 

Hou Y, Shi J, Guo Y, Shi G (2023) DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo. Aging (Albany NY) 15(10):4288–4303

Article  CAS  PubMed  Google Scholar 

Hu Y, Shao Z, Cai X, Liu Y, Shen M, Yao Y, Yuan T, Wang W, Ding F, Xiong L (2019) Mitochondrial Pathway Is Involved in Advanced Glycation End Products-Induced Apoptosis of Rabbit Annulus Fibrosus Cells. Spine (Phila Pa 1976) 44(10):E585–e595

Hua B, Qiu J, Ye X, Kuang Y, Liu X (2023) Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis. Int Immunopharmacol 124(Pt B):111014

Article  CAS  PubMed  Google Scholar 

Huang J, Zhou Q, Ren Q, Luo L, Ji G, Zheng T (2022) Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration. Front Endocrinol (Lausanne) 13:1094394

Article  PubMed  Google Scholar 

Ikuno A, Akeda K, Takebayashi SI, Shimaoka M, Okumura K, Sudo A (2019) Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration. PLoS ONE 14(9):e0222188

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang L, Zhang H, Jia C, Zhang R, Shen C (2023) Epigenetic modifications of inflammation in intervertebral disc degeneration. Ageing Res Rev 87:101902

Article  CAS  PubMed  Google Scholar 

Kim JW, Jeon N, Shin DE, Lee SY, Kim M, Han DH, Shin JY, Lee S (2021) Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc. Int J Mol Sci 22(10):5281

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lan T, Shiyu H, Shen Z, Yan B, Chen J (2021) New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs. Ageing Res Rev 65:101227

Article  CAS  PubMed  Google Scholar 

Li G, Zhang W, Liang H, Yang C (2022) Epigenetic regulation in intervertebral disc degeneration. Trends Mol Med 28(10):803–805

Article  CAS  PubMed  Google Scholar 

Li H, Wang X, Pan H, Xiao C, Wang C, Guo S, Long L, Shi H, Chen H, Li S (2023) The mechanisms and functions of IL-1β in intervertebral disc degeneration. Exp Gerontol 177:112181

Article  CAS  PubMed  Google Scholar 

Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X, Yang C (2019) Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics 9(14):4084–4100

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Qu Y, Liu L, Zhao H, Ma H, Si M, Cheng L, Nie L (2019) PPAR-γ agonist pioglitazone protects against IL-17 induced intervertebral disc inflammation and degeneration via suppression of NF-κB signaling pathway. Int Immunopharmacol 72:138–147

Article  CAS  PubMed  Google Scholar 

Liu Y, Zhao H, Chen N, Li Y, Zheng Z, Sun Z, Zhang Z (2023) PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARγ in cerebral ischemia-reperfusion injury. Brain Res Bull 194:23–34

Article  CAS  PubMed  Google Scholar 

Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM (2023) Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects. J Orthop Translat 39:74–87

Article  PubMed  PubMed Central  Google Scholar 

Lu X, Xu G, Lin Z, Song J, Zhang Y, Wang H, Lu F, Xia X, Ma X, Zou F, Jiang J (2023) Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1. Oxid Med Cell Longev 2023:3626091

Article  PubMed  PubMed Central  Google Scholar 

Lyu FJ, Cui H, Pan H, Mc Cheung K, Cao X, Iatridis JC, Zheng Z (2021) Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions. Bone Res 9(1):7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miao J, Yao S, Sun H, Jiang Z, Gao Z, Xu J, Chen K (2023) Protective Effect of Water-Soluble Acacetin Prodrug on APAP-Induced Acute Liver Injury Is Associated with Upregulation of PPARγ and Alleviation of ER Stress. Int J Mol Sci 24(14):11320

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orrenius S, Gogvadze V, Zhivotovsky B (2015) Calcium and mitochondria in the regulation of cell death. Biochem Biophys Res Commun 460(1):72–81

Article  CAS  PubMed  Google Scholar 

Qimuge N, He Z, Qin J, Sun Y, Wang X, Yu T, Dong W, Yang G, Pang W (2019) Overexpression of DNMT3A promotes proliferation and inhibits differentiation of porcine intramuscular preadipocytes by methylating p21 and PPARg promoters. Gene 696:54–62

Article  CAS  PubMed  Google Scholar 

Rinaldi L, Avgustinova A, Martín M, Datta D, Solanas G, Prats N, Benitah SA (2017) Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ. Elife 6:e21697

Shao X, Xu P, Ji L, Wu B, Zhan Y, Zhuang X, Ou Y, Hua F, Sun L, Li F, Wang X, Chen H, Cheng Y (2023) Low-dose decitabine promotes M2 macrophage polarization in patients with primary immune thrombocytopenia via enhancing KLF4 binding to PPARγ promoter. Clin Transl Med 13(7):e1344

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheng W, Wang Q, Qin H, Cao S, Wei Y, Weng J, Yu F, Zeng H (2023) Osteoarthritis: Role of Peroxisome Proliferator-Activated Receptors. Int J Mol Sci 24(17):13137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh S, Kumar A, Gupta S, Agrawal R (2023) Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD). Tissue Barriers 12(3):2289830

Sun R, Zhu J, Sun K, Gao L, Zheng B, Shi J (2023) Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis. Int J Med Sci 20(13):1679–1697

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vergroesen PP, Kingma I, Emanuel KS, Hoogendoorn RJ, Welting TJ, van Royen BJ, van Dieën JH, Smit TH (2015) Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis Cartilage 23(7):1057–1070

Article  PubMed  Google Scholar 

Wang D, He X, Zheng C, Wang C, Peng P, Gao C, Xu X, Ma Y, Liu M, Yang L, Luo Z (2021) Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration. Front Cell Dev Biol 9:819139

Article