Bryson TD, Ross J, Peterson E, Harding P (2019) Prostaglandin E(2) and an EP4 receptor agonist inhibit LPS-induced monocyte chemotactic protein 5 production and secretion in mouse cardiac fibroblasts via Akt and NF-κB signaling. Prostaglandins Other Lipid Mediat 144:106349. https://doi.org/10.1016/j.prostaglandins.2019.106349

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao JY, Dixon SJ (2016) Mechanisms of ferroptosis. Cell Mol Life Sci 73(11–12):2195–2209. https://doi.org/10.1007/s00018-016-2194-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dépret F, Prud’homme M, Legrand M (2017) A role of remote organs effect in acute kidney injury outcome. Nephron 137(4):273–276. https://doi.org/10.1159/000476077

Article  PubMed  Google Scholar 

Ding C, Ding X, Zheng J, Wang B, Li Y, Xiang H, Dou M, Qiao Y, Tian P, Xue W (2020) miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury. Cell Death Dis 11(10):929. https://doi.org/10.1038/s41419-020-03135-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dolkart O, Liron T, Chechik O, Somjen D, Brosh T, Maman E, Gabet Y (2014) Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study. Am J Sports Med 42(12):2869–2876. https://doi.org/10.1177/0363546514545856

Article  PubMed  Google Scholar 

Erpicum P, Rowart P, Poma L, Krzesinski JM, Detry O, Jouret F (2017) Administration of mesenchymal stromal cells before renal ischemia/reperfusion attenuates kidney injury and may modulate renal lipid metabolism in rats. Sci Rep 7(1):8687. https://doi.org/10.1038/s41598-017-08726-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao G, Jiang S, Ge L, Zhang S, Zhai C, Chen W, Sui S (2019) Atorvastatin improves doxorubicin-induced cardiac dysfunction by modulating Hsp70, Akt, and MAPK signaling pathways. J Cardiovasc Pharmacol 73(4):223–231. https://doi.org/10.1097/fjc.0000000000000646

Article  CAS  PubMed  Google Scholar 

Hong YA, Yang KJ, Jung SY, Park KC, Choi H, Oh JM, Lee SJ, Chang YK, Park CW, Yang CW, Kim SY, Hwang HS (2017) Paricalcitol pretreatment attenuates renal ischemia-reperfusion injury via prostaglandin E(2) receptor EP4 pathway. Oxid Med Cell Longev 2017:5031926. https://doi.org/10.1155/2017/5031926

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W, Zhang H, Cao X, Shah KM, Wang N, Liu M, Luo J (2022) PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. Bone Res 10(1):27. https://doi.org/10.1038/s41413-022-00201-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jorge LB, Coelho FO, Sanches TR, Malheiros D, Ezaquiel de Souza L, Dos Santos F, de Sá Lima L, Scavone C, Irigoyen M, Kuro OM, Andrade L (2019) Klotho deficiency aggravates sepsis-related multiple organ dysfunction. Am J Physiol Renal Physiol 316(3):F438-f448. https://doi.org/10.1152/ajprenal.00625.2017

Article  PubMed  Google Scholar 

Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z, Kellum JA, Liu KD, Mehta RL, Pannu N, Van Biesen W, Vanholder R (2013) Acute kidney injury: an increasing global concern. Lancet 382(9887):170–179. https://doi.org/10.1016/s0140-6736(13)60647-9

Article  PubMed  Google Scholar 

Lannoy M, Valluru MK, Chang L, Abdela-Ali F, Peters DJM, Streets AJ, Ong ACM (2020) The positive effect of selective prostaglandin E2 receptor EP2 and EP4 blockade on cystogenesis in vitro is counteracted by increased kidney inflammation in vivo. Kidney Int 98(2):404–419. https://doi.org/10.1016/j.kint.2020.02.012

Article  CAS  PubMed  Google Scholar 

Li S, He Y, Chen K, Sun J, Zhang L, He Y, Yu H, Li Q (2021) RSL3 drives ferroptosis through NF-κB pathway activation and GPX4 depletion in glioblastoma. Oxid Med Cell Longev 2021:2915019. https://doi.org/10.1155/2021/2915019

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li S, Zhang Y, Yang Y, Chen S, Yang Z, Kuang C, Zhong Y, Liu F (2023) The impact of statin use before intensive care unit admission on patients with acute kidney injury after cardiac surgery. Front Pharmacol 14:1259828. https://doi.org/10.3389/fphar.2023.1259828

Article  CAS  PubMed  PubMed Central  Google Scholar 

Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, VandenBerghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S (2014) Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A 111(47):16836–16841. https://doi.org/10.1073/pnas.1415518111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu GL, Lei R, Duan SB, Tang MM, Luo M, Xu Q (2017) Atorvastatin alleviates iodinated contrast media-induced cytotoxicity in human proximal renal tubular epithelial cells. Exp Ther Med 14(4):3309–3313. https://doi.org/10.3892/etm.2017.4859

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Yu T, Tan X, Jin D, Yang W, Zhang J, Dai L, He Z, Li D, Zhang Y, Liao S, Zhao J, Zhong TP, & Liu C (2023) Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2. Elife, 12. https://doi.org/10.7554/eLife.81438

Liu Y, Zhou L, Lv C, Liu L, Miao S, Xu Y, Li K, Zhao Y, Zhao J (2023) PGE2 pathway mediates oxidative stress-induced ferroptosis in renal tubular epithelial cells. Febs j 290(2):533–549. https://doi.org/10.1111/febs.16609

Martin-Sanchez D, Ruiz-Andres O, Poveda J, Carrasco S, Cannata-Ortiz P, Sanchez-Niño MD, Ruiz Ortega M, Egido J, Linkermann A, Ortiz A, Sanz AB (2017) Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI. J Am Soc Nephrol 28(1):218–229. https://doi.org/10.1681/asn.2015121376

Article  CAS  PubMed  Google Scholar 

Masajtis-Zagajewska A, Nowicki M (2018) Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease - a randomized double blind crossover study. Ren Fail 40(1):700–709. https://doi.org/10.1080/0886022x.2018.1535983

Article  CAS  PubMed  Google Scholar 

Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys M, Ploeg RJ, Leuvenink HGD (2020) Ischemia and reperfusion injury in kidney transplantation: relevant mechanisms in injury and repair. J Clin Med 9(1):253. https://doi.org/10.3390/jcm9010253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan Y, Cao S, Terker AS, Tang J, Sasaki K, Wang Y, Niu A, Luo W, Fan X, Wang S, Wilson MH, Zhang MZ, Harris RC (2022) Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury. Kidney Int 101(1):79–91. https://doi.org/10.1016/j.kint.2021.09.033

Article  CAS  PubMed  Google Scholar 

Pantan R, Tocharus J, Suksamrarn A, Tocharus C (2016) Synergistic effect of atorvastatin and cyanidin-3-glucoside on angiotensin II-induced inflammation in vascular smooth muscle cells. Exp Cell Res 342(2):104–112. https://doi.org/10.1016/j.yexcr.2016.02.017

Article  CAS  PubMed  Google Scholar 

Pefanis A, Ierino FL, Murphy JM, Cowan PJ (2019) Regulated necrosis in kidney ischemia-reperfusion injury. Kidney Int 96(2):291–301. https://doi.org/10.1016/j.kint.2019.02.009

Article  PubMed  Google Scholar 

Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY (2022) Atorvastatin inhibits ferroptosis of H9C2 cells by regulatingSMAD7/hepcidin expression to improve ischemia-reperfusion injury. Cardiol Res Pract 2022:3972829. https://doi.org/10.1155/2022/3972829

Article  PubMed  PubMed Central  Google Scholar 

Pontes HBD, Pontes J, AzevedoNeto E, Vendas G, Miranda JVC, Dias L, Oliva J, Almeida MHM, Chaves IO, Sampaio TL, Santos C, Dourado DM (2018) Evaluation of the effects of atorvastatin and ischemic postconditioning preventing on the ischemia and reperfusion injury: experimental study in rats. Braz J Cardiovasc Surg 33(1):72–81. https://doi.org/10.21470/1678-9741-2017-0108

Article  PubMed