Terramide A: a novel ironophore targeting Acinetobacter baumannii with mechanistic insights into bacterial iron deprivation

Lee CR, Lee JH, Park M, Park KS, Bae IK, Kim YB, Cha CJ, Jeong BC, Lee SH. Biology of acinetobacter baumannii: pathogenesis, antibiotic resistance mechanisms, and prospective treatment options. Front Cell Infect Microbiol. 2017;7:55. https://doi.org/10.3389/fcimb.2017.00055.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harding CM, Hennon SW, Feldman MF. Uncovering the mechanisms of Acinetobacter baumannii virulence. Nat Rev Microbiol. 2018;16:91–102. https://doi.org/10.1038/nrmicro.2017.148.

Article  CAS  PubMed  Google Scholar 

AlAmri AM, AlQurayan AM, Sebastian T, AlNimr AM. Molecular surveillance of multidrug-resistant Acinetobacter baumannii. Curr Microbiol. 2020;77:335–42. https://doi.org/10.1007/s00284-019-01836-z.

Article  CAS  PubMed  Google Scholar 

Czaplewski L, Bax R, Clokie M, Dawson M, Fairhead H, Fischetti VA, Foster S, Gilmore BF, Hancock RE, Harper D, et al. Alternatives to antibiotics—a pipeline portfolio review. Lancet Infect Dis. 2016;16:239–51. https://doi.org/10.1016/S1473-3099(15)00466-1.

Article  CAS  PubMed  Google Scholar 

Dickey SW, Cheung GYC, Otto M. Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017;16:457–71. https://doi.org/10.1038/nrd.2017.23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mortensen BL, Skaar EP. The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host. Front Cell Infect Microbiol. 2013;3:95 https://doi.org/10.3389/fcimb.2013.00095.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weinberg ED. Nutritional immunity. Host’s attempt to with old iron from microbial invaders. JAMA. 1975;231:39–41. https://doi.org/10.1001/jama.231.1.39.

Article  CAS  PubMed  Google Scholar 

Choby JE, Skaar EP. Heme synthesis and acquisition in bacterial pathogens. J Mol Biol. 2016;428:3408–28. https://doi.org/10.1016/j.jmb.2016.03.018.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Runci F, Gentile V, Frangipani E, Rampioni G, Leoni L, Lucidi M, Visaggio D, Harris G, Chen, W, Stahl J, et al. Contribution of active iron uptake to acinetobacter baumannii pathogenicity. Infect Immun. 2019, 87. https://doi.org/10.1128/IAI.00755-18.

Moynie L, Serra I, Scorciapino MA, Oueis E, Page MG, Ceccarelli M, Naismith JHJE. Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii. Elife. 2018;7:e42270.

PubMed  PubMed Central  Google Scholar 

Andrews SC, Robinson AK, Rodriguez-Quinones F. Bacterial iron homeostasis. FEMS Microbiol Rev. 2003;27:215–37. https://doi.org/10.1016/S0168-6445(03)00055-X.

Article  CAS  PubMed  Google Scholar 

Qi J, Chen C, He Y, Wang Y. Genomic analysis and antimicrobial components of M7, an Aspergillus terreus strain derived from the South China Sea. J Fungi. 2022;8:1051 https://doi.org/10.3390/jof8101051.

Article  CAS  Google Scholar 

Wiegand I, Hilpert K, Hancock RE. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc. 2008;3:163–75. https://doi.org/10.1038/nprot.2007.521.

Article  CAS  PubMed  Google Scholar 

Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9:357–9. https://doi.org/10.1038/nmeth.1923.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Feng Z, Wang X, Wang X, Zhang X. DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics. 2010;26:136–8. https://doi.org/10.1093/bioinformatics/btp612.

Article  CAS  PubMed  Google Scholar 

Love MI, Anders S, Kim V, Huber W. RNA-Seq workflow: gene-level exploratory analysis and differential expression. F1000Research. 2015;4:1070 https://doi.org/10.12688/f1000research.7035.1.

Article  PubMed  PubMed Central  Google Scholar 

Okuda S, Yamada T, Hamajima M, Itoh M, Katayama T, Bork P, Goto S, Kanehisa M. KEGG Atlas mapping for global analysis of metabolic pathways. Nucleic Acids Res. 2008;36:W423–426. https://doi.org/10.1093/nar/gkn282.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang A, Sun S, Li L, Dai X, Li H, He Q, Zhu H. Tyrosol from marine Fungi, a novel Quorum sensing inhibitor against Chromobacterium violaceum and Pseudomonas aeruginosa. Bioorg Chem. 2019;91: https://doi.org/10.1016/j.bioorg.2019.103140. 103140.

Article  CAS  PubMed  Google Scholar 

Venkatramanan M, Sankar Ganesh P, Senthil R, Akshay J, Veera Ravi A, Langeswaran K, Vadivelu J, Nagarajan S, Rajendran K, Shankar EM. Inhibition of quorum sensing and biofilm formation in chromobacterium violaceum by fruit extracts of Passiflora edulis. ACS Omega. 2020;5:25605–16. https://doi.org/10.1021/acsomega.0c02483.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niu C, Clemmer KM, Bonomo RA, Rather PN. Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii. J Bacteriol. 2008;190:3386–92. https://doi.org/10.1128/JB.01929-07.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671–5. https://doi.org/10.1038/nmeth.2089.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Li Z, Zhao Y, Feng Y, Zvyagin AV, Wang J, Yang X, Yang B, Lin Q. Novel diabetic foot wound dressing based on multifunctional hydrogels with extensive temperature-tolerant, durable, adhesive, and intrinsic antibacterial properties. ACS Appl Mater Interfaces. 2021;13:26770–81. https://doi.org/10.1021/acsami.1c05514.

Article  CAS  PubMed  Google Scholar 

Ma YX, Wang CY, Li YY, Li J, Wan QQ, Chen JH, Tay FR, Niu LNJAS. Considerations and caveats in combating ESKAPE pathogens against nosocomial infections. Adv Sci (Weinh). 2020;7:1901872.

CAS  PubMed  Google Scholar 

Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ. A common mechanism of cellular death induced by bactericidal antibiotics. Cell. 2007;130:797–810. https://doi.org/10.1016/j.cell.2007.06.049.

Article  CAS  PubMed  Google Scholar 

Hatcher HC, Singh RN, Torti FM, Torti SV. Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Med Chem. 2009;1:1643–70. https://doi.org/10.4155/fmc.09.121.

Article  CAS  PubMed  Google Scholar 

Manning TJ, Thomas J, Osiro S, Smith J, Abadi G, Noble L, Phillips D. Computational studies of Fe(III) binding to bryostatins, bryostatin analogs, siderophores and marine natural products: arguments for ferric complexes in medicinal applications. Nat Prod Res. 2008;22:399–413. https://doi.org/10.1080/14786410701590087.

Article  CAS  PubMed  Google Scholar 

Jayathilake PG, Jana S, Rushton S, Swailes D, Bridgens B, Curtis T, Chen J. Extracellular polymeric substance production and aggregated bacteria colonization influence the competition of microbes in biofilms. Front Microbiol. 2017;8:1865 https://doi.org/10.3389/fmicb.2017.01865.

Article  PubMed  PubMed Central  Google Scholar 

Citarella A, Moi D, Pinzi L, Bonanni D, Rastelli G. Hydroxamic acid derivatives: from synthetic strategies to medicinal chemistry applications. ACS Omega. 2021;6:21843–9. https://doi.org/10.1021/acsomega.1c03628.

Article  CAS  PubMed 

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