Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation

Shibata D, Weiss LM. Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol. 1992;140:769–74.

CAS  PubMed  PubMed Central  Google Scholar 

Dai W, Cheung AK, Ko JM, Cheng Y, Zheng H, Ngan RK, Ng WT, Lee AW, Yau CC, Lee VH, Lung ML. Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma. Cancer Med. 2015;4:1079–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Al-Azzawi F. Mechanism of androgen receptor action. Maturitas. 2009;63:142–8.

Article  CAS  PubMed  Google Scholar 

Nunes DC, Ribeiro JC, Alves MG, Oliveira PF, Bernardino RL. Male sex hormones, metabolic syndrome, and aquaporins: a triad of players in male (in)fertility. Int J Mol Sci. 2023. https://doi.org/10.3390/ijms24031960.

Article  PubMed  PubMed Central  Google Scholar 

Lawrence BM, O’Donnell L, Smith LB, Rebourcet D. New insights into testosterone biosynthesis: novel observations from HSD17B3 deficient mice. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms232415555.

Article  PubMed  PubMed Central  Google Scholar 

Brinkmann AO, Blok LJ, de Ruiter PE, Doesburg P, Steketee K, Berrevoets CA, Trapman J. Mechanisms of androgen receptor activation and function. J Steroid Biochem Mol Biol. 1999;69:307–13.

Article  CAS  PubMed  Google Scholar 

van Royen ME, van Cappellen WA, de Vos C, Houtsmuller AB, Trapman J. Stepwise androgen receptor dimerization. J Cell Sci. 2012;125:1970–9.

PubMed  Google Scholar 

Matsumoto T, Shiina H, Kawano H, Sato T, Kato S. Androgen receptor functions in male and female physiology. J Steroid Biochem Mol Biol. 2008;109:236–41.

Article  CAS  PubMed  Google Scholar 

Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev. 2004;25:276–308.

Article  CAS  PubMed  Google Scholar 

Matsumoto AM. Andropause: clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci. 2002;57:M76-99.

Article  PubMed  Google Scholar 

Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001;1:34–45.

Article  CAS  PubMed  Google Scholar 

Harris WP, Mostaghel EA, Nelson PS, Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol. 2009;6:76–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao J, Wang Q, Tan AF, Loh CJL, Toh HC. Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor. Front Immunol. 2024;15:1416941.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pozas J, Alvarez Rodriguez S, Fernandez VA, Burgos J, Santoni M, Manneh Kopp R, Molina-Cerrillo J, Alonso-Gordoa T. Androgen receptor signaling inhibition in advanced castration resistance prostate cancer: what is expected for the near future? Cancers (Basel). 2022. https://doi.org/10.3390/cancers14246071.

Article  PubMed  Google Scholar 

Chan YX, Yeap BB. Dihydrotestosterone and cancer risk. Curr Opin Endocrinol Diabetes Obes. 2018;25:209–17.

Article  CAS  PubMed  Google Scholar 

Chokkalingam AP, Stanczyk FZ, Reichardt JK, Hsing AW. Molecular epidemiology of prostate cancer: hormone-related genetic loci. Front Biosci. 2007;12:3436–60.

Article  CAS  PubMed  Google Scholar 

Trabert B, Chen J, Devesa SS, Bray F, McGlynn KA. International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973–2007. Andrology. 2015;3:4–12.

Article  CAS  PubMed  Google Scholar 

Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB. Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf). 2006;65:125–31.

Article  CAS  PubMed  Google Scholar 

Yu MW, Chen CJ. Elevated serum testosterone levels and risk of hepatocellular carcinoma. Cancer Res. 1993;53:790–4.

CAS  PubMed  Google Scholar 

Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robertson KD. DNA methylation and human disease. Nat Rev Genet. 2005;6:597–610.

Article  CAS  PubMed  Google Scholar 

Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription. Cell Mol Life Sci. 2002;59:241–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumasia K, Kumar A, Deshpande S, Balasinor NH. Estrogen signaling, through estrogen receptor beta, regulates DNA methylation and its machinery in male germ line in adult rats. Epigenetics. 2017;12:476–83.

Article  PubMed  PubMed Central  Google Scholar 

Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513:202–9.

Article  Google Scholar 

Ignatova E, Seriak D, Fedyanin M, Tryakin A, Pokataev I, Menshikova S, Vakhabova Y, Smirnova K, Tjulandin S, Ajani JA. Epstein-Barr virus-associated gastric cancer: disease that requires special approach. Gastric Cancer. 2020;23:951–60.

Article  PubMed  Google Scholar 

Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12:357–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL. Transcript-level expression analysis of RNA-seq experiments with HISAT. StringTie and Ballgown Nat Protoc. 2016;11:1650–67.

Article  CAS  PubMed  Google Scholar 

Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT, Salzberg SL. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol. 2015;33:290–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson MD, McCarthy DJ, Smyth GK. edgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139–40.

Article  CAS  PubMed  Google Scholar 

Lee SH, Choi SJ, Choi W, Cho S, Cho M, Kim DS, Kang BW, Kim JG, Lee YM, Cho H, Kang H. Cisplatin resistance in Epstein-Barr-virus-associated gastric carcinoma acquired through ATM methylation. Cancers (Basel). 2021. https://doi.org/10.3390/cancers13174252.

Article  PubMed  PubMed Central  Google Scholar 

Szasz AM, Lanczky A, Nagy A, Forster S, Hark K, Green JE, Boussioutas A, Busuttil R, Szabo A, Gyorffy B. Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. Oncotarget. 2016;7:49322–33.

Article  PubMed  PubMed Central  Google Scholar 

Hoadley KA, Yau C, Hinoue T, Wolf DM, Lazar AJ, Drill E, Shen R, Taylor AM, Cherniack AD, Tho

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