Paradoxical effects of adiposity and inflammation on immunotherapy efficacy in gastric cancer: novel insights from real-world data

Huang J, DE Prisnord L, Zhang L, et al. Updated epidemiology of gastrointestinal cancers in East Asia. Nat Rev Gastroenterol Hepatol. 2023;20(5):271–87.

Article  PubMed  Google Scholar 

Cunningham D, Allum WH, Stenning SP, et al; MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006; 355 (1): 11–20.

Kang YK, Boku N, Satoh T, et al. Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2017;390(10111):2461–71.

Article  PubMed  CAS  Google Scholar 

Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body fatness and cancer-viewpoint of the IARC working group. N Engl J Med. 2016;375(8):794–8.

Article  PubMed  PubMed Central  Google Scholar 

Ligibel JA, Alfano CM, Courneya KS, et al. American Society of clinical oncology position statement on obesity and cancer. J Clin Oncol. 2014;32:3568–74.

Article  PubMed  PubMed Central  Google Scholar 

Roccuzzo G, Moirano G, Fava P, et al. Obesity and immune-checkpoint inhibitors in advanced melanoma: a meta-analysis of survival outcomes from clinical studies. Semin Cancer Biol. 2023;91:27–34.

Article  PubMed  CAS  Google Scholar 

Sepesi B, Gold KA, Correa AM, et al. The influence of body mass index on overall survival following surgical resection of non–small cell lung cancer. J Thorac Oncol. 2017;12(8):1280–7.

Article  PubMed  PubMed Central  Google Scholar 

Yoo SK, Chowell D, Valero C, et al. Outcomes among patients with or without obesity and with cancer following treatment with immune checkpoint blockade. JAMA Netw Open. 2022;5(2): e220448.

Article  PubMed  PubMed Central  Google Scholar 

Wang Z, Aguilar EG, Luna JI, et al. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019;25(1):141–51.

Article  PubMed  CAS  Google Scholar 

Lee MJ, Wu Y, Fried SK. Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med. 2013;34(1):1–11.

Article  PubMed  CAS  Google Scholar 

Hwang I, Kyuri J, Kyung CS, et al. GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity. Proc Natl Acad Sci USA. 2019;116(24):11936–45.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Desharnais L, Walsh LA, Quail DF. Exploiting the obesity-associated immune microenvironment for cancer therapeutics. Pharmacol Ther. 2022;229: 107923.

Article  PubMed  CAS  Google Scholar 

Ebadi M, Martin L, Ghosh S, et al. Subcutaneous adiposity is an independent predictor of mortality in cancer patients. Br J Cancer. 2017;117(1):148–55.

Article  PubMed  PubMed Central  Google Scholar 

Lu XL, Kong XH, Wu H, et al. UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders. Cell Metab. 2023;35(8):1390-1405.e8.

Article  PubMed  CAS  Google Scholar 

Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–7.

Article  PubMed  CAS  Google Scholar 

Ramos-Nino M. E. The role of chronic inflammation in obesity-associated cancers. 2013: 2013: 697521

Frasca D, Blomberg BB. Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology. 2016;17(1):7–19.

Article  PubMed  CAS  Google Scholar 

Decman V, Laidlaw BJ, Doering TA, et al. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J Immunol. 2012;188(4):1933–41.

Article  PubMed  CAS  Google Scholar 

Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212–22.

Article  PubMed  CAS  Google Scholar 

Zhang K, Hua YQ, Wang D, et al. Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer. J Transl Med. 2019;17(1):30.

Article  PubMed  PubMed Central  Google Scholar 

Jomrich G, Paireder M, Kristo I, et al. High systemic immune-inflammation index is an adverse prognostic factor for patients with gastroesophageal adenocarcinoma. Ann Surg. 2021;273(3):532–41.

Article  PubMed  Google Scholar 

Tong YS, Tan J, Zhou XL, et al. Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer. J Transl Med. 2017;15(1):221.

Article  PubMed  PubMed Central  Google Scholar 

Giorgi UD, Procopio G, Giannarelli D, et al. Association of systemic inflammation index and body mass index with survival in patients with renal cell cancer treated with nivolumab. Clin Cancer Res. 2019;25(13):3839–46.

Article  PubMed  Google Scholar 

Lee JH, Hyung S, Lee J, et al. Visceral adiposity and systemic inflammation in the obesity paradox in patients with unresectable or metastatic melanoma undergoing immune checkpoint inhibitor therapy: a retrospective cohort study. J Immunother Cancer. 2022;10(8): e005226.

Article  PubMed  PubMed Central  Google Scholar 

Huang H, Liu Q, Zhu L, et al. Prognostic value of preoperative systemic immune-inflammation index in patients with cervical cancer. Sci Rep. 2019;9:3284.

Article  PubMed  PubMed Central  Google Scholar 

Amin MB, Edge S, Greene F, et al editors. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer; 2017.

Google Scholar 

Lin JX, Tang YH, Lin GJ, et al. Association of adjuvant chemotherapy with overall survival among patients with locally advanced gastric cancer after neoadjuvant chemotherapy. JAMA Netw Open. 2022;5(4): e225557.

Article  PubMed  PubMed Central  Google Scholar 

Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1) [J]. Eur J Cancer, 2009, 45(2): 228–247.

Mourtzakis M, Prado C, Lieffers JR, et al. practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008;33(5):997–1006.

Article  PubMed  Google Scholar 

Feliciano E, Popuri K, Cobzas D, et al. Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients. J Cachexia Sarcopenia Muscle. 2020;11(5):1258–69.

Article  Google Scholar 

Pecorelli N, Carrara G, de Cobelli F, et al. Effect of sarcopenia and visceral obesity on mortality and pancreatic fistula following pancreatic cancer surgery. Br J Surg. 2016;103(4):434–42.

Article  PubMed  CAS  Google Scholar 

Kim JH, Chin HM, Hwang SS, et al. Impact of intra-abdominal fat on surgical outcome and overall survival of patients with gastric cancer. Int J Surg. 2014;12(4):346–52.

Article  PubMed  CAS  Google Scholar 

Cortellini A, Bersanelli M, Buti S, et al. A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable. J Immunother Cancer. 2019;7(1):57.

Article  PubMed  PubMed Central  Google Scholar 

Xu BB, Lu J, Zheng ZF, et al. The predictive value of the preoperative C-reactive protein-albumin ratio for early recurrence and chemotherapy benefit in patients with gastric cancer after radical gastrectomy: using randomized phase III trial data. Gastric Cancer. 2019;22(5):1016–28.

Article  PubMed  CAS  Google Scholar 

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74.

Article 

Comments (0)

No login
gif