Pharmaceutical adoption of microphysiological systems in India is contingent on their economics among other aspects

Baruch Y and Holtom BC 2008 Survey response rate levels and trends in Organizational Research. Hum. Relat. 61 1139–1160

Article  Google Scholar 

Benam KH, Villenave R, Lucchesi C, et al. 2016 Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nat. Methods 13 151–157

Article  CAS  PubMed  Google Scholar 

Bhatt T, Bhosale A, Bajantri B, et al. 2019 Sustained secretion of the antimicrobial peptide S100A7 is dependent on the downregulation of caspase-8. Cell Rep. 29 2546-2555.e4

Article  CAS  PubMed  Google Scholar 

BIRAC/DBT 2023 Establishing preclinical models for Drug discovery (https://www.birac.nic.in/desc_new.php?id=1035)

Ewart L and Roth A 2021 Opportunities and challenges with microphysiological systems: a pharma end-user perspective. Nat. Rev. Drug Discov. 20 327–328

Article  CAS  PubMed  Google Scholar 

Ewart L, Apostolou A, Briggs SA, et al. 2022 Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology. Commun. Med. 2 1–16

Article  Google Scholar 

Franzen N, van Harten WH, Retèl VP, et al. 2019 Impact of organ-on-a-chip technology on pharmaceutical R&D costs. Drug Discov. Today 24 1720–1724

Article  PubMed  Google Scholar 

Goldberg AM and Hartung T 2008 Emerging new toxicology: an opportunity for contract research. Eur. Pharm. Contr. 49 42–46

Google Scholar 

Hargrove-Grimes P, Low LA and Tagle DA 2022 Microphysiological systems: stakeholder challenges to adoption in drug development. Cells Tissues Organs 211 269–281

Article  CAS  PubMed  Google Scholar 

Marx U, Akabane T, Andersson TB, et al. 2020 Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug sevelopment. ALTEX 37 365–394

PubMed  PubMed Central  Google Scholar 

Meigs L, Smirnova L, Rovida C, et al. 2018 Animal testing and its alternatives – the most important omics is economics. ALTEX 35 275–305

Article  PubMed  Google Scholar 

MRF India CRO Market Research Report – Forecast to 2032 | MRFR (https://www.marketresearchfuture.com/reports/india-cro-market-2927)

NDCTR_G.S.R. 175E 2023 Amendment in First Schedule regarding use of induced Pluripotent Stem Cells additional testing methods (https://cdsco.gov.in/opencms/opencms/system/modules/CDSCO.WEB/elements/download_file_division.jsp?num_id=OTk1Ng==)

Parvatam S, Bharadwaj S, Radha V, et al. 2020 The need to develop a framework for human-relevant research in India: towards better disease models and drug discovery. J. Biosci. 45 144

Article  PubMed  Google Scholar 

Parvatam S, Mahadik K, Banerjee A, et al. 2023 New horizons of microphysiological systems: India forging its path in human-relevant research. Biol. Open 12 bio059847

Parvatam S, Mittal H, Pistollato F, et al. 2024 Role of standards and funding in accelerating the development and use of microphysiological systems. ALTEX 41 669–670

PubMed  Google Scholar 

Patil, K 2023 Database catalysing collaborations in microphysiological systems research (https://biomed21.org/database-catalysing-collaborations-in-microphysiological-systems-research/)

Ronaldson-Bouchard K and Vunjak-Novakovic G 2018 Organs-on-a-chip: a fast track for engineered human tissues in drug development. Cell Stem Cell 22 310–324

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seok J, Warren HS, Cuenca AG, et al. 2013 Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 110 3507–3512

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sieber S, Wirth L, Cavak N, et al. 2018 Bone marrow-on-a-chip: long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment. J. Tissue Eng. Regen. Med. 12 479–489

Article  CAS  PubMed  Google Scholar 

Waring MJ, Arrowsmith J, Leach AR, et al. 2015 An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14 475–486

Article  CAS  PubMed  Google Scholar 

Watanabe T, Furukawa T, Sharyo S, et al. 2000 Effect of troglitazone on the liver of a Gunn rat model of genetic enzyme polymorphism. J. Toxicol. Sci. 25 423–431

Article  CAS  PubMed  Google Scholar 

Yin DE, Palin AC, Lombo TB, et al. 2023 3D human tissue models and microphysiological systems for HIV and related comorbidities. Trends Biotechnol. 42 526–543

Article  Google Scholar 

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