Authors Lisa Lipp Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Stephan Schmid Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Sophia Rusch Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Peter Malfertheiner Department of Internal Medicine II, University Hospital, LMU Munich, Munich, Germany Martina Müller Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Michael Selgrad Department of Internal Medicine I, University Hospital Regensburg, Regensburg; Department of Gastroenterology and Oncology, Hospital of Fürstenfeldbruck, Fürstenfeldbruck; Germany DOI: https://doi.org/10.15403/jgld-6107 Keywords: Helicobacter pylori, prevalence, liver cirrhosis, extragastric diseases Abstract

Background: Helicobacter pylori (H. pylori) infection remains a significant burden in gastroduodenal diseases. However, contemporary data on the prevalence of H. pylori infection in Germany are limited. Aim: This study aimed to evaluate the current seroprevalence of H. pylori infection in the East Bavarian region by analyzing antibody levels in patients presenting to a German university hospital.

Methods: Serum samples were collected from both inpatients and outpatients of a German university hospital. H. pylori antibody concentrations were measured using a commercially available assay.

Results: The overall prevalence of H. pylori infection was 24.8% (78/314), with the highest infection rates observed in individuals aged over 60 years. A significant association was found between H. pylori infection and liver cirrhosis, with a prevalence of 36.4% (36/99) in patients with liver cirrhosis compared to 19.5% (42/215) in those without liver cirrhosis (p = 0.002). No significant associations were observed between H. pylori infection and type 2 diabetes or coronary artery disease.

Conclusion: This study highlights a low prevalence in H. pylori seropositivity in the eastern part of Bavaria. In patients with liver cirrhosis, we still see a considerable high prevelance of H. pylori. The findings underscore the importance of continued surveillance to monitor trends in H. pylori prevalence and its associations with extragastric diseases.

How to Cite

1.

Lipp L, Schmid S, Rusch S, Malfertheiner P, Müller M, Selgrad M. Prevalence of Helicobacter pylori and its Association with Extragastric Diseases in a Tertiary Hospital from East Bavaria. JGLD [Internet]. 2025 Jun. 28 [cited 2025 Jul. 6];34(2):163-6. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/6107

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