National Cancer Institute. SEER Cancer Stat Facts: NHL — Diffuse Large B-Cell Lymphoma (DLBCL) 2024. https://seer.cancer.gov/statfacts/html/dlbcl.html. Accessed 11 September 2024
Medeiros LJ, Chadburn A, Natkunam Y, Naresh KN. WHO 5th edition classification project. Fifth edition of the world health classification of tumors of the hematopoietic and lymphoid tissues: b-cell neoplasms. Mod Pathol. 2024;37(4):100441. https://doi.org/10.1016/j.modpat.2024.100441.
Campo E, Jaffe ES, Cook JR, et al. The international consensus classification of mature lymphoid neoplasms: a report from the clinical advisory committee blood. 2022;140(4):1229-1253. https://doi.org/10.1182/blood.2022015851.
Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503–11. https://doi.org/10.1038/35000501.
Article CAS PubMed Google Scholar
Lenz G, Wright GW, Emre NC, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A. 2008;105(36):13520–5. https://doi.org/10.1073/pnas.0804295105.
Article PubMed PubMed Central Google Scholar
Shi Y, Xu Y, Shen H, Jin J, Tong H, Xie W. Advances in biology, diagnosis and treatment of DLBCL. Ann Hematol. 2024;103(9):3315–34. https://doi.org/10.1007/s00277-024-05880-z.
Article CAS PubMed PubMed Central Google Scholar
Weber T, Schmitz R. Molecular subgroups of diffuse large B cell lymphoma: biology and implications for clinical practice. Curr Oncol Rep. 2022;24:13–21. https://doi.org/10.1007/s11912-021-01155-2.
Article CAS PubMed PubMed Central Google Scholar
Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103(1):275–82. https://doi.org/10.1182/blood-2003-05-1545.
Article CAS PubMed Google Scholar
Read JA, Koff JL, Nastoupil LJ, Williams JN, Cohen JB, Flowers CR. Evaluating cell-of-origin subtype methods for predicting diffuse large B-cell lymphoma survival: a meta-analysis of gene expression profiling and immunohistochemistry algorithms. Clin Lymphoma Myeloma Leuk. 2014;14(6):460-467.e2. https://doi.org/10.1016/j.clml.2014.05.002.
Article PubMed PubMed Central Google Scholar
Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(4):235–42. https://doi.org/10.1056/NEJMoa011795.
Article CAS PubMed Google Scholar
Feugier P, Van Hoof A, Sebban C, et al. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d’Etude des Lymphomes de l’Adulte. J Clin Oncol. 2005;23(18):4117–26. https://doi.org/10.1200/JCO.2005.09.131.
Article CAS PubMed Google Scholar
Friedberg JW. Relapsed/refractory diffuse large B-cell lymphoma. Hematology Am Soc Hematol Educ Program. 2011;2011:498–505. https://doi.org/10.1182/asheducation-2011.1.498.
Kumar A, Fraz MA, Usman M, et al. Treating diffuse large b cell lymphoma in the very old or frail patients. Curr Treat Options Oncol. 2018;19:50. https://doi.org/10.1007/s11864-018-0565-6.
Article CAS PubMed Google Scholar
Rask Kragh Jørgensen R, Jakobsen LH, Eloranta S, et al. Effectiveness of R-CHOP versus R-CHOEP for treatment of young patients with high-risk diffuse large B-cell lymphoma: a Danish observational population-based study. Eur J Haematol. 2024;113(5):641–650. https://doi.org/10.1111/ejh.14275.
Wästerlid T, Hartman L, Székely E, Jerkeman M. Impact on survival of addition of etoposide to primary chemotherapy in diffuse large B-cell lymphoma: a Swedish Lymphoma Registry study. Hematol Oncol. 2017;35(2):151–7. https://doi.org/10.1002/hon.2256.
Article CAS PubMed Google Scholar
García-Suárez J, Bañas H, Arribas I, De Miguel D, Pascual T, Burgaleta C. Dose-adjusted EPOCH plus rituximab is an effective regimen in patients with poor-prognostic untreated diffuse large B-cell lymphoma: results from a prospective observational study. Br J Haematol. 2007;136(2):276–85. https://doi.org/10.1111/j.1365-2141.2006.06438.x.
Article CAS PubMed Google Scholar
Bartlett NL, Wilson WH, Jung SH, et al. Dose-adjusted EPOCH-R compared With R-CHOP as frontline therapy for diffuse large B-Cell lymphoma: clinical outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303. J Clin Oncol. 2019;37(21):1790–9. https://doi.org/10.1200/JCO.18.01994.
Article CAS PubMed PubMed Central Google Scholar
Nowakowski GS, Willenbacher W, Greil R, et al. Safety and efficacy of durvalumab with R-CHOP or R2-CHOP in untreated, high-risk DLBCL: a phase 2, open-label trial. Int J Hematol. 2022;115(2):222–32. https://doi.org/10.1007/s12185-021-03241-4.
Article CAS PubMed Google Scholar
Olszewski AJ, Phillips TJ, Hoffmann MS, et al. Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study. Blood Adv. 2023;7(20):6055–65. https://doi.org/10.1182/bloodadvances.2023010840.
Article CAS PubMed PubMed Central Google Scholar
Tilly H, Morschhauser F, Sehn LH, et al. Polatuzumab Vedotin in previously untreated diffuse large B-cell lymphoma. N Engl J Med. 2022;386(4):351–63. https://doi.org/10.1056/NEJMoa2115304.
Article CAS PubMed Google Scholar
Maurer MJ, Ghesquières H, Jais JP, et al. Event-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with immunochemotherapy. J Clin Oncol. 2014;32(10):1066–73. https://doi.org/10.1200/JCO.2013.51.5866.
Article PubMed PubMed Central Google Scholar
International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med. 1993;329(14):987–94. https://doi.org/10.1056/NEJM199309303291402.
Kang J, Chae H, Hong JY, et al. Distinct clinical characteristics at diagnosis in patients with late relapses compared with early relapses of diffuse large B-cell lymphoma treated with R-CHOP. Leuk Lymphoma. 2020;6(5):1119–25. https://doi.org/10.1080/10428194.2019.170983124.
Munoz J, Deshpande A, Rimsza L, Nowakowski GS, Kurzrock R. Navigating between scylla and charybdis: a roadmap to do better than Pola-RCHP in DLBCL. Cancer Treat Rev. 2024;124:102691. https://doi.org/10.1016/j.ctrv.2024.102691.
Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma. N Engl J Med. 1995;333(23):1540–5. https://doi.org/10.1056/NEJM199512073332305.
Article CAS PubMed Google Scholar
Gisselbrecht C, Glass B, Mounier N, et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol. 2010;28(27):4184–90. https://doi.org/10.1200/JCO.2010.28.1618.
Article PubMed PubMed Central Google Scholar
Crump M, Neelapu SS, Farooq U, et al. Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. Blood. 2017;130(16):1800–8. https://doi.org/10.1182/blood-2017-03-769620.
Article CAS PubMed PubMed Central Google Scholar
Allen P. Diffuse large b-cell lymphoma in the elderly: current approaches. Curr Oncol Rep. 2020;22(11):114. https://doi.org/10.1007/s11912-020-00976-x.
Article CAS PubMed Google Scholar
Coleman M, Ruan G, Elstrom RL, Martin P, Leonard JP. Metronomic therapy for refractory/relapsed lymphoma: the PEP-C low-dose oral combination chemotherapy regimen. Hematology. 2012;17:S90–2. https://doi.org/10.1179/102453312X13336169155970.
Article CAS PubMed Google Scholar
Crump M, Kuruvilla J, Couban S, et al. Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12. J Clin Oncol. 2014;32(31):3490–6. https://doi.org/10.1200/JCO.2013.53.9593.
Article CAS PubMed Google Scholar
van Imhoff GW, McMillan A, Matasar MJ, et al. Ofatumumab versus rituximab salvage chemoimmunotherapy in relapsed or refractory diffuse large B-cell lymphoma: The ORCHARRD Study. J Clin Oncol. 2017;35(5):544–51. https://doi.org/10.1200/JCO.2016.69.0198.
Comments (0)