Research ArticleOncology Open Access | 10.1172/JCI173757

Mei-Kuang Chen,1,2 Hirohito Yamaguchi,1,3,4 Yuan Gao,1,5 Weiya Xia,1,4 Jeffrey T. Chang,6,7 Yu-Chun Hsiao,4 Tewodros W. Shegute,4 Zong-Shin Lin,4 Chen-Shiou Wu,4 Yu-Han Wang,1,4 Jennifer K. Litton,8 Qingqing Ding,9 Yongkun Wei,1 Yu-Yi Chu,1 Funda Meric-Bernstam,10,11,12 Helen Piwnica-Worms,2 Banu Arun,8 Jordi Rodon Ahnert,10 Jinsong Liu,9 Jun Yao,1 Wei-Chao Chang,4 Hung-Ling Wang,4 Coya Tapia,10,13 Constance T. Albarracin,9 Khandan Keyomarsi,2 Shao-Chun Wang,4 Ying-Nai Wang,1 Gabriel N. Hortobagyi,8 Chunru Lin,1 Liuqing Yang,1 Dihua Yu,1 and Mien-Chie Hung1,4

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Chen, M. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Yamaguchi, H. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Gao, Y. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Xia, W. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Chang, J. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Hsiao, Y. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Shegute, T. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Lin, Z. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Wu, C. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Wang, Y. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Litton, J. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Ding, Q. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Wei, Y. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Chu, Y. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Meric-Bernstam, F. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Piwnica-Worms, H. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Arun, B. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Rodon Ahnert, J. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Liu, J. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Yao, J. in: PubMed | Google Scholar |

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).

Find articles by Chang, W. in: PubMed | Google Scholar

1Department of Molecular and Cellular Oncology and

2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

3Institue of Cell Biology, College of Life Sciences, and

4Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.

5Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

6Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

7Department of Bioinformatics and Computational Biology,

8Department of Breast Medical Oncology, Division of Cancer Medicine,

9Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine,

10Department of Investigational Cancer Therapeutics,

11Department of Breast Surgical Oncology, Division of Surgery,

12Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, and

13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Address correspondence to: Mien-Chie Hung or Hirohito Yamaguchi, Office of the President, China Medical University, 91 Hsueh-Shih Road, North District, Taichung 40402, Taiwan. Phone: 886.42.205.3366. Email: mhung@cmu.edu.tw or mhung77030@gmail.com (MCH). Email: hirohitoyamaguchi@yahoo.com or hyamaguchi@mail.cmu.edu.tw (HY).