Extended Letrozole Treatment for Ovulation Induction and Clinical Pregnancy in Conventional Treatment-resistant Polycystic Ovary Syndrome Patients: A Prospective Parallel Randomized Clinical Trial

Bitsis G, Domali E, Drakaki E, Drakakis P, et al. Infertility and female sexual dysfunction: a literature review. Hellenic J Obstetrics Gynecol. 2023;22(4):163–9.

Google Scholar 

Franik S, Eltrop SM, Kremer JA, Kiesel L, et al. Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2018;5(5):cd010287.

PubMed  Google Scholar 

Wang R, Li W, Bordewijk EM, Legro RS, et al. First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Hum Reprod Update. 2019;25(6):717–32.

CAS  PubMed  Google Scholar 

Costello MF, Misso ML, Balen A, Boyle J, et al. A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome. Aust N Z J Obstet Gynaecol. 2019;59(6):867–73.

PubMed  Google Scholar 

Liu X, Zhang J, Wang S. Global, regional, and national burden of infertility attributable to PCOS, 1990–2019. Hum Reprod. 2024;39(1):108–18.

PubMed  Google Scholar 

Ovarian Stimulation T, Bosch E, Broer S, Griesinger G, et al. ESHRE guideline: ovarian stimulation for IVF/ICSI. Hum Reprod Open. 2020;2020(2):hoaa009.

PubMed  Google Scholar 

Mitwally MF, Casper RF, editors. Aromatase inhibitors in ovulation induction. Seminars in reproductive medicine; 2004: Copyright© 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, Newyork

Legro RS, Brzyski RG, Diamond MP, Coutifaris C, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–29.

PubMed  PubMed Central  Google Scholar 

Tsiami AP, Goulis DG, Sotiriadis AI, Kolibianakis EM. Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis. Hormones (Athens). 2021;20(3):449–61.

PubMed  Google Scholar 

Franik S, Le QK, Kremer JA, Kiesel L, et al. Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2022;9(9):cd010287.

PubMed  Google Scholar 

Roque M, Tostes AC, Valle M, Sampaio M, et al. Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis. Gynecol Endocrinol. 2015;31(12):917–21.

CAS  PubMed  Google Scholar 

Li M, Ruan X, Mueck AO. Management strategy of infertility in polycystic ovary syndrome. Global Health J. 2022;6(2):70–4.

CAS  Google Scholar 

Cunha A, Póvoa AM. Infertility management in women with polycystic ovary syndrome: a review. Porto Biomedical Journal. 2021;6(1): e116.

PubMed  PubMed Central  Google Scholar 

Balen AH, Morley LC, Misso M, Franks S, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687–708.

PubMed  Google Scholar 

Amer SA, Smith J, Mahran A, Fox P, et al. Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome. Hum Reprod. 2017;32(8):1631–8.

CAS  PubMed  PubMed Central  Google Scholar 

Joham AE, Piltonen T, Lujan ME, Kiconco S, et al. Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome. Clin Endocrinol. 2022;97(2):165–73.

Google Scholar 

Zhu X, Fu Y. Extending letrozole treatment duration is effective in inducing ovulation in women with polycystic ovary syndrome and letrozole resistance. Fertil Steril. 2023;119(1):107–13.

CAS  PubMed  Google Scholar 

Jahan S, Deeba F, Ishrat S, Banu J, et al. Low dose-extended letrozole versus double dose-short letrozole protocol for ovulation induction in polycystic ovary syndrome. Int J Reprod Contracept Obstet Gynecol. 2022;11:2974–82.

Google Scholar 

Morad A, Barakat E, Bayomey A, Hassen M. Extended letrozole regimen for treatment of clomiphene resistant polycystic ovary syndrome patients. Benha Med J. 2021;38(3):962–71.

Google Scholar 

Wafa Y, El-Omda FA, Kamaly MAM. Extended letrozole regimen for treatment of clomiphene resistant PCO patient. Al-Azhar Int Med J. 2023;4(12):50.

Google Scholar 

Mandelbaum RS, Agarwal R, Melville S, Violette CJ, et al. A comparison of letrozole regimens for ovulation induction in women with polycystic ovary syndrome. F&S Reports. 2024;5(2):170–5.

Google Scholar 

Zhu X, Lang J, Wang Q, Fu Y. Extended versus conventional letrozole regimen in patients with polycystic ovary syndrome undergoing their first ovulation induction cycle: a prospective randomized controlled trial. Hum Reprod Open. 2024;2024(3):hoae046.

PubMed  PubMed Central  Google Scholar 

Ramezannezhad P, Rahmati R, Zarimeidani F, Karimi M, et al. Personalized Patient Education: Patient’s Perspective. Iranian Biomed J. 2024;28:66.

Google Scholar 

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