Necrotizing Neutrophilic Dermatoses: Considerations for the Inpatient Dermatologist

Jorizzo JL, Solomon AR, Zanolli MD, Leshin B. Neutrophilic vascular reactions. J Am Acad Dermatol. 1988;19:983–1005.

CAS  PubMed  Google Scholar 

Sanchez IM, Lowenstein S, Johnson KA, et al. Clinical features of neutrophilic dermatosis variants resembling necrotizing fasciitis. JAMA Dermatol. 2019;155:79–84.

PubMed  Google Scholar 

Gowda A, Christensen L, Polly S, Barlev D. Necrotizing neutrophilic dermatosis: a diagnostic challenge with a need for multi-disciplinary recognition, a case report. Annals Med Surg. 2020;57:299–302.

Google Scholar 

Otero TMN, Barber SR, Yeh DD, Quraishi SA. Necrotizing soft tissue infection or sweet syndrome: surgery versus no surgery?: A case report. A A Case Rep. 2017;8:182–5.

PubMed  PubMed Central  Google Scholar 

Kroshinsky D, Alloo A, Rothschild B, Cummins J, Tan J, Montecino R, Hoang MP, Duncan L, Mihm M, Sepehr A. Necrotizing sweet syndrome: A new variant of neutrophilic dermatosis mimicking necrotizing fasciitis. J Am Acad Dermatol. 2012;67:945–54.

PubMed  Google Scholar 

Chaudhry AA, Baker KS, Gould ES, Gupta R. Necrotizing fasciitis and its mimics: what radiologists need to know. Am J Roentgenol. 2015;204:128–39.

Google Scholar 

Dissemond J, Marzano AV, Hampton PJ, Ortega-Loayza AG. Pyoderma gangrenosum: treatment options. Drugs. 2023;83:1255–67.

PubMed  PubMed Central  Google Scholar 

Demirdover C, Geyik A, Vayvada H. Necrotising fasciitis or pyoderma gangrenosum: a fatal dilemma. Int Wound J. 2019;16:1347–53.

PubMed  PubMed Central  Google Scholar 

Ahronowitz I, Harp J, Shinkai K. Etiology and management of pyoderma gangrenosum a comprehensive review. Am J Clin Dermatol. 2012;13:191–211.

Chia MW, Teo L, Tay YK, Poh WT. Pustular pyoderma gangrenosum: an uncommon variant which is easily misdiagnosed. Dermatol Online J. 2008;14:21.

CAS  PubMed  Google Scholar 

Almukhtar R, Armenta AM, Martin J, Goodwin BP, Vincent B, Lee B, Dacso MM. Delayed diagnosis of post-surgical pyoderma gangrenosum: A multicenter case series and review of literature. Int J Surg Case Rep. 2018;44:152–6.

PubMed  PubMed Central  Google Scholar 

Wangia MW, Mitchell CL, Wesson SK, Scott E, Glavin FL. Pyoderma gangrenosum or necrotizing fasciitis? A diagnostic conundrum. Case report and literature review. J Pediatr Surg Case Rep. 2013;1:139–42.

Google Scholar 

Ruocco E, Sangiuliano S, Gravina AG, Miranda A, Nicoletti G. Pyoderma gangrenosum: an updated review. J Eur Acad Dermatol Venereol. 2009;23:1008–17.

CAS  PubMed  Google Scholar 

Becker SL, Kody S, Fett NM, Hines A, Alavi A, Ortega-Loayza AG. Approach to the atypical wound. Am J Clin Dermatol. 2024;25:559–84.

PubMed  Google Scholar 

Haag C, Hansen T, Hajar T, Latour E, Keller Jesse J, Shinkai K, Ortega Loayza AG. Comparison of three diagnostic frameworks for pyoderma gangrenosum. J Investig Dermatol. 2021;141:59–63.

CAS  PubMed  Google Scholar 

Nemlander A, Ahonen J, Wiktorowicz K, von Willebrand E, Hekali R, Lalla M, Hayry P. Effect of cyclosporine on wound healing. Transplantation. 1983;36:1–6.

PubMed  Google Scholar 

Wong CH, Wang YS. The diagnosis of necrotizing fasciitis. Curr Opin Infect Dis. 2005;18:101–6.

Schwartz M, Pasternack M. Cellulitis, necrotizing fasciitis and subcutaneous tissue infections. In: Bennett J, Dolin R, Blaser M, editors. Principles and practice of infectious diseases. 9th ed. Philadelphia: Elsevier; 2005. p. 1282.

Google Scholar 

Kaustio M, Hautala T, Seppanen MR. Primary immunodeficiency, a possible cause of neutrophilic necrotizing dermatosis. JAMA Dermatol. 2019;155:863–4.

PubMed  Google Scholar 

Kaustio M, Haapaniemi E, Göös H, et al. Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes. J Allergy Clin Immunol. 2017;140:782–96.

CAS  PubMed  Google Scholar 

Wong CH, Khin LW, Heng KS, Tan KC, Low CO. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004;32:1535–41.

PubMed  Google Scholar 

Tso DK, Singh AK. Necrotizing fasciitis of the lower extremity: imaging pearls and pitfalls. Br J Radiol. 2018;91:1088.

Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ. Necrotizing skin and soft-tissue infections in the intensive care unit. Clin Microbiol Infect. 2020;26:8–17.

CAS  PubMed  Google Scholar 

Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJC, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014. https://doi.org/10.1093/cid/ciu296.

Article  PubMed  PubMed Central  Google Scholar 

Park S, Shin H, Lee DH, Koh EH, Lee JH, Lee GW (2022) Pyoderma gangrenosum mimicking necrotizing fasciitis on magnetic resonance imaging: a case report and literature review. Am J Case Rep. https://doi.org/10.12659/AJCR.931734

Allaw F, Wehbe S, Kanj SS. Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment. Curr Opin Infect Dis. 2024;37:105–11.

CAS  PubMed  Google Scholar 

Howell EC, Keeley JA, Kaji AH, Deane MR, Kim DY, Putnam B, Lee SL, Woods AL, Neville AL. Chance to cut: defining a negative exploration rate in patients with suspected necrotizing soft tissue infection. Trauma Surg Acute Care Open. 2019. https://doi.org/10.1136/tsaco-2018-000264.

Article  PubMed  PubMed Central  Google Scholar 

Stevens DL, Bryant AE. Necrotizing soft-tissue infections. N Engl J Med. 2017;377:2253–65.

PubMed  Google Scholar 

Urbina T, Razazi K, Ourghanlian C, Woerther PL, Chosidow O, Lepeule R, de Prost N. Antibiotics in necrotizing soft tissue infections. Antibiotics. 2021. https://doi.org/10.3390/antibiotics10091104.

Article  PubMed  PubMed Central  Google Scholar 

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