Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy

O’Neill TW, McCabe PS, McBeth J. Update on the epidemiology, risk factors and disease outcomes of osteoarthritis. Best Pract Res Clin Rheumatol. 2018;32:312–26.

Article  PubMed  Google Scholar 

Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022;18:258–75.

Article  PubMed  PubMed Central  Google Scholar 

Xia B, Di C, Zhang J, Hu S, Jin H, Tong P. Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int. 2014;95:495–505.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tao J, Deng H, Li Z, Cao L, Rao Y, Yin Z. Macrophage-targeted, ROS-removing and H2S-releasing nanomicelle encapsulated in hydrogel microspheres for the treatment of osteoarthritis. Chem Eng J. 2025;507: 160345.

Article  CAS  Google Scholar 

Im GI. Tissue engineering in osteoarthritis: current status and prospect of mesenchymal stem cell therapy. BioDrugs. 2018;32:183–92.

Article  PubMed  Google Scholar 

Chen X, Wang L, Zhang J, Yan H, Wang S, Xiao J. Controlled release of ceria and ferric oxide nanoparticles via collagen hydrogel for enhanced osteoarthritis therapy. Adv Healthc Mater. 2024;13: e2401507.

Article  PubMed  Google Scholar 

Lv Z, Wang P, Li W, Xie Y, Sun W, Jin X, et al. Bifunctional TRPV1 targeted magnetothermal switch to attenuate osteoarthritis progression. Research (Wash D C). 2024;2024(7):0316.

Google Scholar 

Rim YA, Nam Y, Ju JH. The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression. Int J Mol Sci. 2020;21(7):2358.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen L, Yang J, Cai Z, Huang Y, Xiao P, Chen H, et al. Mitochondrial-oriented injectable hydrogel microspheres maintain homeostasis of chondrocyte metabolism to promote subcellular therapy in osteoarthritis. Research (Wash D C). 2024;7:0306.

PubMed  CAS  Google Scholar 

Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021;325:568–78.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cai J, Liu LF, Qin Z, Liu S, Wang Y, Chen Z, et al. Natural morin-based metal organic framework nanoenzymes modulate articular cavity microenvironment to alleviate osteoarthritis. Research (Wash D C). 2023;6:0068.

PubMed  CAS  Google Scholar 

Xu B, Ye J, Yuan FZ, Zhang JY, Chen YR, Fan BS, et al. Advances of stem cell-laden hydrogels with biomimetic microenvironment for osteochondral repair. Front Bioeng Biotechnol. 2020;8:247.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yang Z, Li H, Yuan Z, Fu L, Jiang S, Gao C, et al. Endogenous cell recruitment strategy for articular cartilage regeneration. Acta Biomater. 2020;114:31–52.

Article  PubMed  CAS  Google Scholar 

Burdick JA, Mauck RL, Gorman JH 3rd, Gorman RC. Acellular biomaterials: an evolving alternative to cell-based therapies. Sci Transl Med. 2013;5:176ps4.

Article  PubMed  PubMed Central  Google Scholar 

Im GI. Endogenous cartilage repair by recruitment of stem cells. Tissue Eng Part B Rev. 2016;22:160–71.

Article  PubMed  Google Scholar 

Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, et al. Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation. Stem Cells Transl Med. 2019;8:746–57.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Copp G, Robb KP, Viswanathan S. Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success. Cell Mol Immunol. 2023;20:626–50.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gupta PK, Maheshwari S, Cherian JJ, Goni V, Sharma AK, Tripathy SK, et al. Efficacy and safety of stempeucel in osteoarthritis of the knee: a phase 3 randomized, double-blind, multicenter, placebo-controlled study. Am J Sports Med. 2023;51:2254–66.

Article  PubMed  Google Scholar 

Lee WS, Kim HJ, Kim KI, Kim GB, Jin W. Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis: a phase IIb, randomized, placebo-controlled clinical trial. Stem Cells Transl Med. 2019;8:504–11.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tan D, Huang Z, Zhao Z, Chen X, Liu J, Wang D, et al. Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review). Int J Mol Med. 2024;53:2.

Article  PubMed  CAS  Google Scholar 

Lagneau N, Tournier P, Nativel F, Maugars Y, Guicheux J, Le Visage C, et al. Harnessing cell-material interactions to control stem cell secretion for osteoarthritis treatment. Biomaterials. 2023;96: 122091.

Article  Google Scholar 

Zheng W, Li H, Hu K, Li L, Bei M. Chondromalacia patellae: current options and emerging cell therapies. Stem Cell Res Ther. 2021;12:412.

Article  PubMed  PubMed Central  Google Scholar 

Yu H, Huang Y, Yang L. Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis. Ageing Res Rev. 2022;80: 101684.

Article  PubMed  CAS  Google Scholar 

An X, Wang J, Xu K, Zhao RC, Su J. Perspectives on osteoarthritis treatment with mesenchymal stem cells and Radix Achyranthis Bidentatae. Aging Dis. 2024;15:1029–45.

PubMed  PubMed Central  Google Scholar 

Rizzo MG, Best TM, Huard J, Philippon M, Hornicek F, Duan Z, et al. Therapeutic perspectives for inflammation and senescence in osteoarthritis using mesenchymal stem cells, mesenchymal stem cell-derived extracellular vesicles and senolytic agents. Cells. 2023;12:1421.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sharun K, Muthu S, Mankuzhy PD, Pawde AM, Chandra V, Lorenzo JM, et al. Cell-free therapy for canine osteoarthritis: current evidence and prospects. Vet Q. 2022;42:224–30.

Article  PubMed  PubMed Central  Google Scholar 

Bertolino GM, Maumus M, Jorgensen C, Noël D. Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells. Nat Rev Rheumatol. 2023;19:682–94.

Article  PubMed  Google Scholar 

Liu S, Cheng S, Chen B, Xiao P, Zhan J, Liu J, et al. Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis. J Nanobiotechnol. 2023;21:429.

Article  CAS  Google Scholar 

Yin B, Ni J, Witherel CE, Yang M, Burdick JA, Wen C, et al. Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics. Theranostics. 2022;12:207–31.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yakufu M, Jia Q, Li C, Ma C, Zhang P, Abudushalamu M, et al. Injectable biomimetic hybrid nanofibers for targeting cartilage in early osteoarthritis treatment. Chem Eng J. 2024;2024(490): 151790.

Article  Google Scholar 

Deng Y, Chen X, Zhang Z, Zhao X, Zhu Z, Wu C, et al. A novel apoferritin nanocage with ECM promoting, ferroptosis suppressing and inflammation targeting property for osteoarthritis therapy. Chem Eng J. 2024;493: 152398.

Article  CAS  Google Scholar 

Xu Y, Gu X, Li X, Chen Y, Wei Z, Wang J, et al. β-Diketone functionalized microspheres chelate reactive iron via metal coordination for cartilage repair. Adv Healthc Mater. 2025:e2403933

You B, Zhou C, Yang Y. MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis. Ageing Res Rev. 2023;85: 101864.

Article  PubMed  CAS 

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