Zhou J, Zheng R, Zhang S, Zeng H, Wang S, Chen R, Sun K, Li M, Gu J, Zhuang G, Wei W (2021) Colorectal cancer burden and trends: comparison between China and major burden countries in the world. Chin J Cancer Res 33:1–10

Article  PubMed  PubMed Central  Google Scholar 

Kasi A, Handa S, Bhatti S, Umar S, Bansal A, Sun W (2020) Molecular pathogenesis and classification of colorectal carcinoma. Curr Colorectal Cancer Rep 16:97–106

PubMed  PubMed Central  Google Scholar 

Jiang SX, Zarrin A, Shahidi N (2024) T1 colorectal cancer management in the era of minimally invasive endoscopic resection. World J Gastrointest Oncol 16:2284–2294

Article  PubMed  PubMed Central  Google Scholar 

Ichimasa K, Kudo SE, Kouyama Y, Mochizuki K, Takashina Y, Misawa M, Mori Y, Hayashi T, Wakamura K, Miyachi H (2022) Tumor location as a prognostic factor in T1 colorectal cancer. J Anus Rectum Colon 6:9–15

Article  PubMed  PubMed Central  Google Scholar 

Ong ML, Schofield JB (2016) Assessment of lymph node involvement in colorectal cancer. World J Gastrointest Surg 8:179–192

Article  PubMed  PubMed Central  Google Scholar 

Takamatsu M, Yamamoto N, Kawachi H, Nakano K, Saito S, Fukunaga Y, Takeuchi K (2022) Prediction of lymph node metastasis in early colorectal cancer based on histologic images by artificial intelligence. Sci Rep 12:2963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji H, Hu C, Yang X, Liu Y, Ji G, Ge S, Wang X, Wang M (2023) Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions. Signal Transduct Target Ther 8:367

Article  PubMed  PubMed Central  Google Scholar 

Bernklev L, Nilsen JA, Augestad KM, Holme Ø, Pilonis ND (2024) Management of non-curative endoscopic resection of T1 colon cancer. Best Pract Res Clin Gastroenterol 68:101891

Article  PubMed  Google Scholar 

Corre F, Albouys J, Tran VT, Lepilliez V, Ratone JP, Coron E, Lambin T, Rahmi G, Karsenti D, Canard JM et al (2024) Impact of surgery after endoscopically resected high-risk T1 colorectal cancer: results of an emulated target trial. Gastrointest Endosc 99:408-416.e402

Article  PubMed  Google Scholar 

Takamaru H, Saito Y, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Sekine S, Ochiai H, Tsukamoto S, Shida D, Kanemitsu Y (2021) Endoscopic resection before surgery does not affect the recurrence rate in patients with high-risk T1 colorectal cancer. Clin Transl Gastroenterol 12:e00336

Article  PubMed  PubMed Central  Google Scholar 

Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, Nordlinger B, van de Velde CJ, Balmana J, Regula J et al (2012) ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making. Annals Oncol 23:2479–2516

Article  CAS  Google Scholar 

Zaffalon D, Daca-Alvarez M, Saez de Gordoa K, Pellisé M (2023) Dilemmas in the clinical management of pT1 colorectal cancer. Cancers (Basel) 15(13):3511

Article  PubMed  Google Scholar 

Zwager LW, Bastiaansen BAJ, Montazeri NSM, Hompes R, Barresi V, Ichimasa K, Kawachi H, Machado I, Masaki T, Sheng W et al (2022) Deep submucosal invasion is not an independent risk factor for lymph node metastasis in T1 colorectal cancer: a meta-analysis. Gastroenterology 163:174–189

Article  CAS  PubMed  Google Scholar 

Yamaoka Y, Shiomi A, Kagawa H, Hino H, Manabe S, Chen K, Nanishi K, Notsu A (2022) Lymph node metastasis in T1 colorectal cancer with the only high-risk histology of submucosal invasion depth ≥ 1000 μm. Int J Colorectal Dis 37:2387–2395

Article  PubMed  Google Scholar 

Mou S, Soetikno R, Shimoda T, Rouse R, Kaltenbach TJSE (2013) Pathologic predictive factors for lymph node metastasis in submucosal invasive (T1) colorectal cancer: a systematic review and meta-analysis. Surg Endosc 27:2692–2703

Article  PubMed  Google Scholar 

Hamady ZZ, Lodge JP, Welsh FK, Toogood GJ, White A, John T, Rees M (2014) One-millimeter cancer-free margin is curative for colorectal liver metastases: a propensity score case-match approach. Ann Surg 259:543–548

Article  PubMed  Google Scholar 

Dhar DK, Yoshimura H, Kinukawa N, Maruyama R, Tachibana M, Kohno H, Kubota H, Nagasue N (2005) Metastatic lymph node size and colorectal cancer prognosis. J Am Coll Surg 200:20–28

Article  PubMed  Google Scholar 

Lee LY, Lin CY, Cheng NM, Tsai CY, Hsueh C, Fan KH, Wang HM, Hsieh CH, Ng SH, Yeh CH et al (2021) Poor tumor differentiation is an independent adverse prognostic variable in patients with locally advanced oral cavity cancer–Comparison with pathological risk factors according to the NCCN guidelines. Cancer Med 10:6627–6641

Article  PubMed  PubMed Central  Google Scholar 

Takahashi H, Ohigashi H, Ishikawa O, Gotoh K, Yamada T, Nagata S, Tomita Y, Eguchi H, Doki Y, Yano M (2012) Perineural invasion and lymph node involvement as indicators of surgical outcome and pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer. Ann Surg 255:95–102

Article  PubMed  Google Scholar 

Sur D, Advani S, Braithwaite D (2022) MicroRNA panels as diagnostic biomarkers for colorectal cancer: a systematic review and meta-analysis. Front Med (Lausanne) 9:915226

Article  PubMed  Google Scholar 

Qu A, Yang Y, Zhang X, Wang W, Liu Y, Zheng G, Du L, Wang CJE (2018) Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans. EBioMedicine 37:125–133

Article  PubMed  PubMed Central  Google Scholar 

Li M, Zhang J, Dan Y, Yao Y, Dai W, Cai G, Yang G, Tong T (2020) A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer. J Transl Med 18:46

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasahara K, Katsumata K, Saito A, Ishizaki T, Enomoto M, Mazaki J, Tago T, Nagakawa Y, Matsubayashi J, Nagao T et al (2022) Artificial intelligence predicts lymph node metastasis or risk of lymph node metastasis in T1 colorectal cancer. Int J Clin Oncol 27:1570–1579

Article  CAS  PubMed  Google Scholar 

Tate DJ, Sidhu M, Bar-Yishay I, Desomer L, Brown G, Hourigan LF, Lee EYT, Moss A, Raftopoulos S, Singh R et al (2020) Impact of en bloc resection on long-term outcomes after endoscopic mucosal resection: a matched cohort study. Gastrointest Endosc 91:1155-1163.e1151

Article  PubMed  Google Scholar 

Ramspek CL, Jager KJ, Dekker FW, Zoccali C, van Diepen M (2021) External validation of prognostic models: what, why, how, when and where? Clin Kidney J 14:49–58

Article  PubMed  Google Scholar