Teede, H. J. et al. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil. Steril. https://doi.org/10.1016/j.fertnstert.2023.07.025 (2023).
Azziz, R., Marin, C., Hoq, L., Badamgarav, E. & Song, P. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J. Clin. Endocrinol. Metab. 90, 4650–4658 (2005).
Article CAS PubMed Google Scholar
Riestenberg, C., Jagasia, A., Markovic, D., Buyalos, R. P. & Azziz, R. Health care-related economic burden of polycystic ovary syndrome in the United States: pregnancy-related and long-term health consequences. J. Clin. Endocrinol. Metab. 107, 575–585 (2022). This paper highlights that early diagnosis and interventions could possibly reduce the risk of developing comorbidities and the health-care-related economic burden of PCOS.
Yadav, S. et al. Direct economic burden of mental health disorders associated with Polycystic ovary syndrome: systematic review and meta-analysis. eLife 12, e85338 (2023).
Article PubMed PubMed Central Google Scholar
Liu, Q. et al. A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome. Diabetologia 65, 1483–1494 (2022).
Article CAS PubMed PubMed Central Google Scholar
Ruth, K. S. et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat. Med. 26, 252–258 (2020).
Article CAS PubMed PubMed Central Google Scholar
Long, C. et al. Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: a systematic review and meta-analysis. Front. Endocrinol. 13, 980405 (2022).
Cooney, L. G. & Dokras, A. Cardiometabolic risk in polycystic ovary syndrome: current guidelines. Endocrinol. Metab. Clin. North Am. 50, 83–95 (2021).
Hoeger, K. M., Dokras, A. & Piltonen, T. Update on PCOS: consequences, challenges, and guiding treatment. J. Clin. Endocrinol. Metab. 106, e1071–e1083 (2021).
Zhuang, C. et al. Cardiovascular risk according to body mass index in women of reproductive age with polycystic ovary syndrome: a systematic review and meta-analysis. Front. Cardiovasc. Med. 9, 822079 (2022).
Article PubMed PubMed Central Google Scholar
Ollila, M. M., Hoek, A. & Piltonen, T. T. The association between polycystic ovary syndrome and early cardiovascular disease morbidity strengthens. Eur. J. Endocrinol. 189, R4–R5 (2023).
Berni, T. R., Morgan, C. L. & Rees, D. A. Women with polycystic ovary syndrome have an increased risk of major cardiovascular events: a population study. J. Clin. Endocrinol. Metab. 106, e3369–e3380 (2021). This study shows that women with PCOS have a higher incidence of myocardial infarction, angina pectoris and revascularization.
Article PubMed PubMed Central Google Scholar
Millan-de-Meer, M., Luque-Ramirez, M., Nattero-Chavez, L. & Escobar-Morreale, H. F. PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis. Hum. Reprod. Update 29, 741–772 (2023).
van der Ham, K. et al. Change in androgenic status and cardiometabolic profile of middle-aged women with polycystic ovary syndrome. J. Clin. Med. 12, 5226 (2023).
Article PubMed PubMed Central Google Scholar
Johnson, J. E., Daley, D., Tarta, C. & Stanciu, P. I. Risk of endometrial cancer in patients with polycystic ovarian syndrome: a meta-analysis. Oncol. Lett. 25, 168 (2023). This study shows that women with PCOS have a fivefold increased risk of developing endometrial cancer.
Article PubMed PubMed Central Google Scholar
Hanna, F., Wu, P., Heald, A. & Fryer, A. Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome. BMJ 382, e071675 (2023).
Mills, G., Badeghiesh, A., Suarthana, E., Baghlaf, H. & Dahan, M. H. Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies. Hum. Reprod. 35, 1666–1674 (2020). This study shows that women with PCOS have an increased risk for pregnancy complications, including gestational diabetes and hypertension, independent of coexisting metabolic conditions.
Gibson-Helm, M., Teede, H., Dunaif, A. & Dokras, A. Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 102, 604–612 (2017).
Dapas, M. & Dunaif, A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr. Rev. 43, 927–965 (2022).
Article PubMed PubMed Central Google Scholar
Leinonen, J. T. et al. Genetic analyses implicate complex links between adult testosterone levels and health and disease. Commun. Med. 3, 4 (2023).
Article CAS PubMed PubMed Central Google Scholar
Xue, A. et al. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nat. Commun. 9, 2941 (2018).
Article PubMed PubMed Central Google Scholar
Davitadze, M. et al. Body image concerns in women with polycystic ovary syndrome: a systematic review and meta-analysis. Eur. J. Endocrinol. 189, R1–R9 (2023).
Nasiri-Amiri, F., Faramarzi, M., Omidvar, S. & Alizadeh-Navaei, R. Depression and anxiety in adolescents and young women with polycystic ovary syndrome: a systematic review and meta-analysis. Int. J. Adolesc. Med. Health 35, 233–242 (2023).
Mousa, A., Thien Tay, C. & Teede, H. Technical Report for the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome https://doi.org/10.26180/23625288.v1 (Monash University, 2023).
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 81, 19–25 (2004).
Lizneva, D. et al. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil. Steril. 106, 6–15 (2016).
March, W. A. et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum. Reprod. 25, 544–551 (2010).
Piltonen, T. T. et al. AMH as part of the diagnostic PCOS workup in large epidemiological studies. Eur. J. Endocrinol. 188, 547–554 (2023).
Wu, Q., Gao, J., Bai, D., Yang, Z. & Liao, Q. The prevalence of polycystic ovarian syndrome in Chinese women: a meta-analysis. Ann. Palliat. Med. 10, 74–87 (2021).
Moran, C., Arriaga, M., Rodriguez, G. & Moran, S. Obesity differentially affects phenotypes of polycystic ovary syndrome. Int. J. Endocrinol. 2012, 317241 (2012).
Article PubMed PubMed Central Google Scholar
Teede, H. J. et al. Longitudinal weight gain in women identified with polycystic ovary syndrome: results of an observational study in young women. Obesity 21, 1526–1532 (2013).
Kataoka, J. et al. Prevalence of polycystic ovary syndrome in women with severe obesity — effects of a structured weight loss programme. Clin. Endocrinol. 91, 750–758 (2019). This study demonstrates that the prevalence of PCOS increases up to 25% with severe obesity.
van Keizerswaard, J., Dietz de Loos, A. L. P., Louwers, Y. V. & Laven, J. S. E. Changes in individual polycystic ovary syndrome phenotypical characteristics over time: a long-term follow-up study. Fertil. Steril. 117, 1059–1066 (2022).
Kujanpaa, L. et al. Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: a population-based cohort study. Acta Obstet. Gynecol. Scand. 101, 728–736 (2022).
Article PubMed PubMed Central Google Scholar
Ollila, M. M. et al. Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria-a prospective population-based cohort study. Eur. J. Endocrinol. 189, 96–105 (2023).
Ollila, M. M. et al. Weight gain and dyslipidemia in early adulthood associate with polycystic ovary syndrome: prospective cohort study. J. Clin. Endocrinol. Metab. 101, 739–747 (2016).
Article CAS PubMed Google Scholar
Hagberg, C. E. & Spalding, K. L. White adipocyte dysfunction and obesity-associated pathologies in humans. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-023-00680-1 (2023).
Lim, S. S., Davies, M. J., Norman, R. J. & Moran, L. J. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum. Reprod. Update 18, 618–637 (2012).
Article CAS PubMed Google Scholar
Koivuaho, E. et al. Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS. Int. J. Obes. 43, 1370–1379 (2019). This study demonstrates that early weight gain in childhood plays a crucial role in the emerging PCOS, highlighting the importance of early preventive interventions against metabolic disorders.
Kakoly, N. S., Earnest, A., Moran, L. J., Teede, H. J. & Joham, A. E. Group-based developmental BMI trajectories, polycystic ovary syndrome, and gestational diabetes: a community-based longitudinal study. BMC Med. 15, 195 (2017).
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