Chen L, Min J, Wang F. Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Therapy. 2022;7(1):378. https://doi.org/10.1038/s41392-022-01229-y.

Article  CAS  Google Scholar 

Cobine PA, Moore SA, Leary SC. Getting out what you put in: copper in mitochondria and its impacts on human disease. Biochim et Biophys Acta Mol Cell Res. 2021;1868(1):118867. https://doi.org/10.1016/j.bbamcr.2020.118867.

Article  CAS  Google Scholar 

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S. Golub T.R. Copper induces cell death by targeting lipoylated TCA cycle proteins. Sci (New York). 2022;375(6586):1254–61. https://doi.org/10.1126/science.abf0529.

Article  CAS  Google Scholar 

World Health Organization. Global cancer burden growing, amidst mounting need for services. 2024. https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services (Accessed on 04 April 2024).

Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative stress in cancer. Cancer Cell. 2020;38(2):167–97. https://doi.org/10.1016/j.ccell.2020.06.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180–3. https://doi.org/10.1016/j.redox.2015.01.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galadari S, Rahman A, Pallichankandy S, Thayyullathil F. Reactive oxygen species and cancer paradox: to promote or to suppress? Free Radic Biol Med. 2017;104:144–64. https://doi.org/10.1016/j.freeradbiomed.2017.01.004.

Article  CAS  PubMed  Google Scholar 

Kardos J, Héja L, Simon Á, Jablonkai I, Kovács R, Jemnitz K. Copper signalling: causes and consequences. Cell Communication Signal. 2018;16(1):71. https://doi.org/10.1186/s12964-018-0277-3.

Article  CAS  Google Scholar 

Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S. Roux P.P. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nat Commun. 2020;11(1):3701. https://doi.org/10.1038/s41467-020-17549-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang AP, Chen PY, Wang XY, Liu ZY, Zhang DM, Luo Y, Liao GC, Long JA, Zhong RH, Zhou ZG, Xu YJ, Xu XJ, Ling WH, Chen MS, Zhang YJ, Zhu HL. Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort. Int J Cancer. 2019;144(11):2823–32. https://doi.org/10.1002/ijc.31991.

Article  CAS  PubMed  Google Scholar 

Zhang X, Yang Q. Association between serum copper levels and lung cancer risk: a meta-analysis. J Int Med Res. 2018;46(12):4863–73. https://doi.org/10.1177/0300060518798507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jian Z, Guo H, Liu H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Oxidative stress, apoptosis and inflammatory responses involved in copper-induced pulmonary toxicity in mice. Aging. 2020;12(17):16867–86. https://doi.org/10.18632/aging.103585.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uriu-Adams JY, Keen CL. Copper, oxidative stress, and human health. Mol Aspects Med. 2005;26(4–5):268–98. https://doi.org/10.1016/j.mam.2005.07.015.

Article  CAS  PubMed  Google Scholar 

Gaetke LM, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology. 2003;189(1–2):147–63. https://doi.org/10.1016/s0300-483x(03)00159-8.

Article  CAS  PubMed  Google Scholar 

Xie X, Liu L. Global status and research trends of cuprotosis research: a bibliometrics study via CiteSpace. Medicine. 2023;102(24):e34020. https://doi.org/10.1097/MD.0000000000034020.

Article  PubMed  PubMed Central  Google Scholar 

Offiong OE, Etok C, Martelli S. Synthesis and biological activity of platinum group metal complexes of o-vanillin thiosemicarbazones. Farmaco. 1996;51(12):801–8.

CAS  PubMed  Google Scholar 

Xie J, Yang Y, Gao Y, He J. Cuproptosis: mechanisms and links with cancers. Mol Cancer. 2023;22(1):46. https://doi.org/10.1186/s12943-023-01732-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu L, Liu K, Wang F, Su Y. Cuproptosis and its application in different cancers: an overview. Mol Cell Biochem. 2023;478(12):2683–93. https://doi.org/10.1007/s11010-023-04693-4.

Article  CAS  PubMed  Google Scholar 

Garrick MD, Singleton ST, Vargas F, Kuo HC, Zhao L, Knöpfel M, Davidson T, Costa M, Paradkar P, Roth JA. Garrick L.M. DMT1: which metals does it transport? Biol Res. 2006;39(1):79–85. https://doi.org/10.4067/s0716-97602006000100009.

Article  CAS  PubMed  Google Scholar 

Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C. The molecular mechanisms of copper metabolism and its roles in human diseases. Eur J Physiol. 2020;472(10):1415–29. https://doi.org/10.1007/s00424-020-02412-2.

Article  CAS  Google Scholar 

Kim H, Wu X, Lee J. SLC31 (CTR) family of copper transporters in health and disease. Mol Aspects Med. 2013;34(2–3):561–70. https://doi.org/10.1016/j.mam.2012.07.011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang D, Tian Z, Zhang P, Zhen L, Meng Q, Sun B, Xu X, Jia T, Li S. The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease. Biomed Pharmacotherapy. 2023;163:114830. https://doi.org/10.1016/j.biopha.2023.114830.

Article  CAS  Google Scholar 

Ban XX, Wan H, Wan XX, Tan YT, Hu XM, Ban HX, Chen XY, Huang K, Zhang Q, Xiong K. Copper metabolism and cuproptosis: molecular mechanisms and therapeutic perspectives in neurodegenerative diseases. Curr Med Sci. 2024;44(1):28–50. https://doi.org/10.1007/s11596-024-2832-z.

Article  CAS  PubMed  Google Scholar 

Culotta VC, Klomp LW, Strain J, Casareno RL, Krems B, Gitlin JD. The copper chaperone for superoxide dismutase. J Biol Chem. 1997;272(38):23469–72. https://doi.org/10.1074/jbc.272.38.23469.

Article  CAS  PubMed  Google Scholar 

Cobine PA, Pierrel F, Winge DR. Copper trafficking to the mitochondrion and assembly of copper metalloenzymes. Biochim Biophys Acta. 2006;1763(7):759–72. https://doi.org/10.1016/j.bbamcr.2006.03.002.

Article  CAS  PubMed  Google Scholar 

Hatori Y, Lutsenko S. The role of copper chaperone Atox1 in coupling redox homeostasis to intracellular copper distribution. Antioxid (Basel Switzerland). 2016;5(3):25. https://doi.org/10.3390/antiox5030025.

Article  CAS  Google Scholar 

Freedman JH, Ciriolo MR, Peisach J. The role of glutathione in copper metabolism and toxicity. J Biol Chem. 1989;264(10):5598–605.

Article  CAS  PubMed  Google Scholar 

Ahmadi N, Mahjoub S, Haji Hosseini R, TaherKhani M, Moslemi D. Alterations in serum levels of trace element in patients with breast cancer before and after chemotherapy. Caspian J Intern Med. 2018;9(2):134–9. https://doi.org/10.22088/cjim.9.2.134.

Article  PubMed  PubMed Central